ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
- CAS No.
- 194673-12-6
- Chemical Name:
- ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
- Synonyms
- 6-oxo-2-(trifL;Ethyl 6-oxo-2-(trifluoromethyl);)-1,4,5,6-tetrahydro-3-pyridinecarboxyL;-1,4,5,6-tetrahydropyridine-3-carboxylate;3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(triflu...;Ethyl 2-oxo-6-(trifluoromethyl)-3,4-dihydro-1h-pyridine-5-carboxylate;ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate;6-Hydroxy-2-trifluoromethyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester;2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyridine-5-carboxylic acid ethyl ester;1,4,5,6-Tetrahydro-6-oxo-2-(trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester
- CBNumber:
- CB32462216
- Molecular Formula:
- C9H10F3NO3
- Molecular Weight:
- 237.18
- MDL Number:
- MFCD00975005
- MOL File:
- 194673-12-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate | 043511 | 5.00g | $51 |
| Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate | 043511 | 10.00g | $81 |
| Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate | 043511 | 25.00g | $158 |
| Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 97% | E49848 | 100mg | $52 |
| Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 97% | E49848 | 250mg | $58 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HS Code | 2933399990 |
ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 043511 | Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate | 194673-12-6 | 5.00g | $51 | 2026-05-18 | Buy |
| Matrix Scientific | 043511 | Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate | 194673-12-6 | 10.00g | $81 | 2026-05-18 | Buy |
| Matrix Scientific | 043511 | Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate | 194673-12-6 | 25.00g | $158 | 2026-05-18 | Buy |
| Synthonix | E49848 | Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 97% | 194673-12-6 | 100mg | $52 | 2026-05-06 | Buy |
| Synthonix | E49848 | Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 97% | 194673-12-6 | 250mg | $58 | 2026-05-06 | Buy |
ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Chemical Properties,Uses,Production
Synthesis
79-06-1
372-31-6
194673-12-6
GENERAL STEPS: A mixture of ethyl 4,4,4-trifluoroacetoacetate (14.7 mL, 0.1 mol, 1.6 eq.), acrylamide (4.5 g, 0.063 mol, 1.0 eq.), and p-toluene sulfonate (0.156 g, 0.82 mmol, 0.013 eq.) in toluene (60 mL) was refluxed in a Dean-Stark device for for 38 hours to azeotropically remove the resulting water. Upon completion of the reaction, most of the toluene was removed by slow distillation at atmospheric pressure and the reaction mixture was concentrated to a smaller volume. Toluene (60 mL) was added again to the concentrated mixture and the distillation and concentration process was repeated as described above. This operation was performed three times. Finally, the reaction mixture was further concentrated under vacuum and the resulting solid residue was purified by fast column chromatography (silica gel as stationary phase, eluent gradient: from hexane/ethyl acetate 9:1 to hexane/ethyl acetate 8:2). Purification afforded the target compound ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate as a brown solid (3.8 g, 25% yield). The product was analyzed by LC-MS (ESI+) and showed molecular ion peaks MH+: 238, 210, 190.
References
[1] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 40; 44
[2] Patent: WO2004/29026, 2004, A1. Location in patent: Page 33-34
[3] Patent: WO2004/29027, 2004, A1. Location in patent: Page 30
ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29120 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +86-13336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| ANHUI BYERSEN BIOTECH CO. LTD | +86-15385096007 +86-17755058861 | amy@byersenchemical.com | China | 10000 | 58 |
View Lastest Price from ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
194673-12-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-13 | ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
194673-12-6
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
194673-12-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
194673-12-6
- $1.00
- 99.0%
- Career Henan Chemical Co
