(4-fluorotetrahydro-2H-pyran-4-yl)methanamine
- CAS No.
- 883442-46-4
- Chemical Name:
- (4-fluorotetrahydro-2H-pyran-4-yl)methanamine
- Synonyms
- (4-fluorooxan-4-yl)methanol;4-HydroxyMethyl-4-fluoro-...;4-Fluorotetrahydropyran-4-methanol;(4,4-Dimethyl-cyclohexyl)-methanol;(4-Fluorotetrahydropyran-4-yl)methanol;2H-Pyran-4-methanol, 4-fluorotetrahydro-;4-HydroxyMethyl-4-fluoro-tetrahydro-2H-pyran;(4-fluorotetrahydro-2H-pyran-4-yl)methanamine
- CBNumber:
- CB32470518
- Molecular Formula:
- C6H11FO2
- Molecular Weight:
- 134.15
- MDL Number:
- MFCD18072006
- MOL File:
- 883442-46-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(4-fluorotetrahydro-2H-pyran-4-yl)methanamine price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 276873 | (4-Fluorotetrahydro-2H-pyran-4-yl)methanamine Asreported | 883442-46-4 | 10g | $8147 | 2026-06-03 | Buy |
| Biosynth | IKB44246 | (4-Fluorotetrahydro-2H-pyran-4-yl)methanol | 883442-46-4 | 100mg | $385 | 2026-06-04 | Buy |
| Biosynth | IKB44246 | (4-Fluorotetrahydro-2H-pyran-4-yl)methanol | 883442-46-4 | 1g | $1003 | 2026-06-04 | Buy |
| Synthonix | H8035 | 4-Hydroxymethyl-4-fluoro-tetrahydro-2H-pyran 97.0% | 883442-46-4 | 500mg | $410 | 2026-05-06 | Buy |
| Synthonix | H8035 | 4-Hydroxymethyl-4-fluoro-tetrahydro-2H-pyran 97.0% | 883442-46-4 | 1g | $590 | 2026-05-06 | Buy |
(4-fluorotetrahydro-2H-pyran-4-yl)methanamine Chemical Properties, Uses, Production
Uses
(4-Fluorotetrahydro-2H-pyran-4-yl)methanol is a reactant used to prepare GPR40 agonists and beta secretase inhibitors.
Synthesis
1150617-60-9
883442-46-4
General procedure for the synthesis of (4-fluorotetrahydro-2H-pyran-4-yl)methanol from methyl 4-fluorotetrahydro-2H-pyran-4-carboxylate: 4-fluorotetrahydro-2H-pyran-4-carboxylic acid methyl ester (840 mg, 5.18 mmol) was dissolved in tetrahydrofuran (20 mL) under nitrogen protection and cooled to 0 °C. Subsequently, lithium aluminum hydride (394 mg, 10.36 mmol) was slowly added. The reaction mixture was stirred continuously at 0 °C for 3 hours. Upon completion of the reaction, saturated aqueous ammonium chloride solution (10 mL) was carefully added to quench the reaction. The reaction mixture was filtered and the filtrate was extracted with ethyl acetate (10 mL × 2). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the intermediate (4-fluorotetrahydro-2H-pyran-4-yl)methanol (550 mg, 4.10 mmol, 80% yield) as an oil, which was used directly in the next step of the reaction. The 1H NMR (CD3OD, 400 MHz) data of the intermediate were as follows: δ 3.81-3.85 (m, 2H), 3.70-3.76 (m, 2H), 3.64 (s, 1H), 3.59 (s, 1H), 1.67-1.90 (m, 4H).
References
[1] Patent: WO2018/50684, 2018, A1. Location in patent: Page/Page column 68
(4-fluorotetrahydro-2H-pyran-4-yl)methanamine Preparation Products And Raw materials
Raw materials
Preparation Products
(4-fluorotetrahydro-2H-pyran-4-yl)methanamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| hebeidiyuanpharmaceuticaltechnology co.,ltd | 13803176464 | 519798876@qq.com | China | 1891 | 58 |
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| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Dtchem Laboratories,（Gan Su）Co.,Ltd. | 18993961550 18993966060 | sales@techbiochem.com | China | 773 | 61 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Shanghai Huaxing Biological Technology Co., Ltd. | 18621295758; 18621295758 | 1449085402@qq.com | China | 1973 | 55 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shanghai WangFa Chemical Technology Co., Ltd. | 13918479294 | xiebenfa@163.com | China | 4354 | 58 |
