1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- CAS No.
- 287193-00-4
- Chemical Name:
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- Synonyms
- tert-butyl 3-ethynylpyrrolidine-1-carboxylate;1-Boc-3-ethynylpyrrolidine;1-Boc-3-ethynylpyrrolidin...;acid, 3-ethynyl-, 1,1-dimethylethyl ester;tert-Butyl 3-ethynyl-1-pyrrolidinecarboxylate;1,1-Dimethylethyl 3-ethynyl-1-pyrrolidinecarboxylate;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester;3-ethynyl-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester - [P7677]
- CBNumber:
- CB32473670
- Molecular Formula:
- C11H17NO2
- Molecular Weight:
- 195.26
- MDL Number:
- MFCD10698160
- MOL File:
- 287193-00-4.mol
- MSDS File:
- SDS
| Boiling point | 249.2±29.0 °C(Predicted) |
|---|---|
| Density | 1.04±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | -2.53±0.40(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | 0.9898°(C=0.1566g/100ml MEOH) |
| InChI | 1S/C11H17NO2/c1-5-9-6-7-12(8-9)10(13)14-11(2,3)4/h1,9H,6-8H2,2-4H3 |
| InChIKey | KTDGOUSDBBFBRO-UHFFFAOYSA-N |
| SMILES | CC(C)(OC(N1CCC(C#C)C1)=O)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319-H302 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 112402 | 1-Boc-3-ethynylpyrrolidine | 287193-00-4 | 250.00mg | $59 | 2026-05-18 | Buy |
| Matrix Scientific | 112402 | 1-Boc-3-ethynylpyrrolidine | 287193-00-4 | 1.00g | $90 | 2026-05-18 | Buy |
| Matrix Scientific | 112402 | 1-Boc-3-ethynylpyrrolidine | 287193-00-4 | 5.00g | $139 | 2026-05-18 | Buy |
| Synthonix | P7677 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester 97.0% | 287193-00-4 | 250mg | $61 | 2026-05-06 | Buy |
| Synthonix | P7677 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester 97.0% | 287193-00-4 | 1g | $100 | 2026-05-06 | Buy |
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Chemical Properties, Uses, Production
Application
tert-butyl 3-ethynylpyrrolidine-1-carboxylate is a useful research chemical.
Synthesis
90965-06-3
59379-02-1
287193-00-4
GENERAL STEPS: 1-Boc-3-pyrrolidinecarboxaldehyde (580 mg, 2.91 mmol) was dissolved in methanol (15 mL) at room temperature, and potassium carbonate (1.00 g, 7.28 mmol) and dimethyl (1-diazido-2-oxopropyl)phosphonate (839 mg, 4.37 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 3 h. After completion of the reaction, it was filtered through a short diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with an eluent gradient of 0 to 50% ethyl acetate/hexane to give a colorless oily product. The product was allowed to stand in a refrigerator and cured to give 1-Boc-3-ynylpyrrolidine white solid (374 mg, 66% yield).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 18, p. 8417 - 8443
[2] Patent: US2016/9720, 2016, A1. Location in patent: Paragraph 0250
[3] Patent: US2016/9711, 2016, A1. Location in patent: Paragraph 0242; 0243; 0244
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Shanghai XIYU Chemical Technology Co.,Ltd. | 021-15000143735 15221126179 | sala@xiyuchem.com | China | 375 | 55 |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
View Latest Price from 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-01-15 | 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
287193-00-4
- $9.80
- ≥99%
- Career Henan Chemical Co
