2-Chloro-3-methylbenzal dehyde
- CAS No.
- 61563-28-8
- Chemical Name:
- 2-Chloro-3-methylbenzal dehyde
- Synonyms
- 2-Chloro-3-methylbenzal dehyde;Benzaldehyde, 2-chloro-3-methyl-;2-Chloro-3-methylbenzaldehyde 95+%
- CBNumber:
- CB32487646
- Molecular Formula:
- C8H7ClO
- Molecular Weight:
- 154.59
- MDL Number:
- MFCD11845907
- MOL File:
- 61563-28-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2912290090 |
2-Chloro-3-methylbenzal dehyde price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | LCA56328 | 2-Chloro-3-methylbenzaldehyde | 61563-28-8 | 5g | $354 | 2026-06-04 | Buy |
| Apolloscientific | OR54473 | 2-Chloro-3-methylbenzaldehyde 95% | 61563-28-8 | 250mg | $45 | 2026-06-04 | Buy |
| Apolloscientific | OR54473 | 2-Chloro-3-methylbenzaldehyde 95% | 61563-28-8 | 5g | $222 | 2026-06-04 | Buy |
| Activate Scientific | AS28800 | 2-Chloro-3-methylbenzaldehyde 98% | 61563-28-8 | 1g | $68 | 2026-06-04 | Buy |
| Apolloscientific | OR54473 | 2-Chloro-3-methylbenzaldehyde 95% | 61563-28-8 | 10g | $417 | 2026-06-04 | Buy |
2-Chloro-3-methylbenzal dehyde Chemical Properties, Uses, Production
Synthesis
61563-27-7
61563-28-8
The general procedure for the synthesis of 2-chloro-3-methylbenzaldehyde from (2-chloro-3-methylphenyl)methanol is as follows: 1. dichloromethane (30 mL) was cooled to -78 °C under nitrogen protection, and a solution of DCM (10 mL) with oxalyl chloride (1.34 mL, 15.2 mmol, 1.2 eq.) and DMSO (2.2 mL, 31.7 mmol, 2.5 eq.) was added sequentially. 2. After stirring the reaction mixture for 15 minutes, a solution of 2-chloro-3-methylbenzyl alcohol (2 g, 12.7 mmol, 1 eq.) in DCM (12 mL) was added slowly and dropwise. 3. After continuing the reaction for 30 minutes, triethylamine (9.03 mL, 63.5 mmol, 5 eq.) was added in a single addition and the reaction mixture was slowly warmed to room temperature over a period of 1 hour. 4. After completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate (50 mL) and the aqueous layer was extracted with DCM (2 x 50 mL). 5. The organic phases were combined, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to give 2-chloro-3-methylbenzaldehyde as a yellow oil (1.8 g, 91.4% yield). 6. The product was characterized by 1H NMR (300 MHz, CDCl3): δ= 10.53 (1H, s, CHO), 7.81-7.74 (1H, m, ArH), 7.53-7.46 (1H, m, ArH), 7.34-7.23 (1H, m, ArH), 2.46 (3H, s, CH3).
References
[1] Patent: WO2004/52858, 2004, A2. Location in patent: Page 133
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 892 - 913
[3] Patent: WO2017/156177, 2017, A1. Location in patent: Paragraph 00276
[4] Patent: WO2017/156181, 2017, A1. Location in patent: Paragraph 00250
[5] Patent: WO2017/156165, 2017, A1. Location in patent: Paragraph 00316; 00319; 00320
2-Chloro-3-methylbenzal dehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Beijing Eternalchem Co,. Ltd. | 010-59484199 18611897322;18611897322; | sales@eternalchem.com | China | 1993 | 60 |
| Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd. | 0515-89701588 13770166955 | orgunion@orgunion.com | China | 620 | 55 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 | |
| LABTER PHARMATECH(BEIJING) CO.,LTD | 010-56330744 18310155299 | sales@labter.com.cn | China | 19999 | 55 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
