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ChemicalBook >> CAS DataBase List >>2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Structure
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride structure
CAS No.
97657-92-6
Chemical Name:
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
Synonyms
CS-784;DiMebone HCl;Dimebon 2HCl;Latrepirdine 2HCl;DiMebone dihydrochloride;DiMeboline dihydrochloride;Latrepirdine dihydrochloride;Latrepirdine (Dimebolin) HCl;Dimebone dihydrochloride hydrate;Dimebolin dihydrochloride hydrate
CBNumber:
CB32489958
Molecular Formula:
C21H25N3.2ClH
Molecular Weight:
392.371
MDL Number:
MFCD17215933
MOL File:
97657-92-6.mol
MSDS File:
SDS
Last updated:2025-04-27 16:16:43
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2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Properties

Melting point 220-222 °C
storage temp. Desiccate at RT
solubility H2O: ≥10mg/mL
form powder
color white to off-white
Water Solubility H2O: ≥10mg/mL
FDA UNII 8B9414QQ5M
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/38
Safety Statements  26-36/39
WGK Germany  3
NFPA 704
0
2 0

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D6196 Dimebon dihydrochloride hydrate ≥98% (HPLC) 97657-92-6 5mg $148 2024-03-01 Buy
Sigma-Aldrich D6196 Dimebon dihydrochloride hydrate ≥98% (HPLC) 97657-92-6 25mg $581 2024-03-01 Buy
Cayman Chemical 10011349 Dimebolin (hydrochloride) ≥98% 97657-92-6 1mg $23 2024-03-01 Buy
Cayman Chemical 10011349 Dimebolin (hydrochloride) ≥98% 97657-92-6 5mg $100 2024-03-01 Buy
Cayman Chemical 10011349 Dimebolin (hydrochloride) ≥98% 97657-92-6 10mg $155 2024-03-01 Buy
Product number Packaging Price Buy
D6196 5mg $148 Buy
D6196 25mg $581 Buy
10011349 1mg $23 Buy
10011349 5mg $100 Buy
10011349 10mg $155 Buy

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Chemical Properties,Uses,Production

Uses

Latrepirdine is an antihistamine drug used initially in Russia. Recently research have explore the potential of Latrepirdine to demonstrate activities against neurodegenerative conditions.

Biological Activity

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT 6 and 5-HT 7 ), α -adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β -amyloid fragment.

in vivo

Latrepirdine treatment of TgCRND8 transgenic mice is associated with improved learning behavior and with a reduction in accumulation of Aβ42 and α-synuclein. Male, 90-day-old TgCRND8 mice or their wild-type littermates (nTg) receive 31 consecutive once daily i.p. injections of either 3.5 mg/kg Latrepirdine or 0.9% saline (vehicle). At the culmination of treatment, mice are tested for cued and contextual fear conditioning using a paradigm that has been widely accepted for evaluating learning and memory deficits in APP transgenic mice. A significant increase in cued memory only among Latrepirdine-versus vehicle-treated TgCRND8 mice (p=0.01) is observed. A weak, non-significant trend toward an improvement in contextual memory among Latrepirdine-versus vehicle-treated mice (p=0.099) is also observed[1].

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Suppliers

Global( 112)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29856 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7890 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58

View Lastest Price from 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Latrepirdine dihydrochloride pictures 2025-04-27 Latrepirdine dihydrochloride
97657-92-6
 US $48.00 / mL 98.45% 10g TargetMol Chemicals Inc.
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride pictures 2025-04-17 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
97657-92-6
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride pictures 2019-07-06 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
97657-92-6
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Spectrum

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride(97657-92-6)1HNMR

97657-92-6(2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride)Related Search:

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CS-784 Latrepirdine 2HCl 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Dimebon 2HCl 2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole hydrochloride 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indoledihydrochloride DiMebone HCl DiMeboline dihydrochloride DiMebone dihydrochloride Latrepirdine dihydrochloride 2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate Dimebolin dihydrochloride hydrate Dimeboline dihydrochloride hydrate Dimebone dihydrochloride hydrate 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole,dihydrochloride 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride ISO 9001：2015 REACH Latrepirdine (Dimebolin) HCl Dimebolin dihydrochloride|||Latrepirdine|||Latrepirdine 2HCl|||Dimebolin Latrepirdine dihydrochloride, 10 mM in DMSO 2,8-Dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride , Latrepirdine 2HCl 2,3,4,5-Tetrahydro-2,8-dimethy1-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride 97657-92-6 C21H25N32HCl C21H25N32ClH C21H27Cl2N3 Inhibitors