ChemicalBook >> CAS DataBase List >>2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride structure

CAS No.: 97657-92-6

Chemical Name:: 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

Synonyms: CS-784;DiMebone HCl;Dimebon 2HCl;Latrepirdine 2HCl;DiMebone dihydrochloride;Latrepirdine 2HCl ，S1245;DiMeboline dihydrochloride;Latrepirdine dihydrochloride;Latrepirdine (Dimebolin) HCl;Dimebone dihydrochloride hydrate

CBNumber:: CB32489958

Molecular Formula:: C21H25N3.2ClH

Molecular Weight:: 392.371

MDL Number:: MFCD17215933

MOL File:: 97657-92-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

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2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Properties

Melting point	220-222 °C
storage temp.	Desiccate at RT
solubility	H2O: ≥10mg/mL
form	powder
color	white to off-white
Water Solubility	H2O: ≥10mg/mL
InChI	1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2
InChIKey	QQHQMWVYYVVAOV-UHFFFAOYSA-N
SMILES	O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4
FDA UNII	8B9414QQ5M
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P305+P351+P338

Hazard Codes

Risk Statements

22-36/38

Safety Statements

26-36/39

WGK Germany

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2

NFPA 704

	0
2		0

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D6196	Dimebon dihydrochloride hydrate ≥98% (HPLC)	97657-92-6	5mg	$163	2026-04-30	Buy
Sigma-Aldrich	D6196	Dimebon dihydrochloride hydrate ≥98% (HPLC)	97657-92-6	25mg	$640	2026-04-30	Buy
Cayman Chemical	10011349	Dimebolin (hydrochloride) ≥98%	97657-92-6	1mg	$26	2026-04-30	Buy
Cayman Chemical	10011349	Dimebolin (hydrochloride) ≥98%	97657-92-6	5mg	$110	2026-04-30	Buy
Cayman Chemical	10011349	Dimebolin (hydrochloride) ≥98%	97657-92-6	10mg	$171	2026-04-30	Buy

Product number	Packaging	Price	Buy
D6196	5mg	$163	Buy
D6196	25mg	$640	Buy
10011349	1mg	$26	Buy
10011349	5mg	$110	Buy
10011349	10mg	$171	Buy

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Chemical Properties, Uses, Production

Uses

Latrepirdine is an antihistamine drug used initially in Russia. Recently research have explore the potential of Latrepirdine to demonstrate activities against neurodegenerative conditions.

Biological Activity

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT 6 and 5-HT 7 ), α -adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β -amyloid fragment.

in vivo

Latrepirdine treatment of TgCRND8 transgenic mice is associated with improved learning behavior and with a reduction in accumulation of Aβ42 and α-synuclein. Male, 90-day-old TgCRND8 mice or their wild-type littermates (nTg) receive 31 consecutive once daily i.p. injections of either 3.5 mg/kg Latrepirdine or 0.9% saline (vehicle). At the culmination of treatment, mice are tested for cued and contextual fear conditioning using a paradigm that has been widely accepted for evaluating learning and memory deficits in APP transgenic mice. A significant increase in cued memory only among Latrepirdine-versus vehicle-treated TgCRND8 mice (p=0.01) is observed. A weak, non-significant trend toward an improvement in contextual memory among Latrepirdine-versus vehicle-treated mice (p=0.099) is also observed^[1].

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Suppliers

Global Suppliers ( 121)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
ZHIWE CHEMTECH CO LTD	021-20221225 13917446399	zwchem@163.com	China	518	61
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
China Kouting Group Limited	+86 (21) 5811-6473 5811-6475	sales@koutingchina.com	China	494	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Taizhou Yikang Chemical Co., Ltd.	0576-88501337 18057652630	sales@yikangchemicals.com	China	272	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
ZHIWE CHEMTECH CO LTD	61
Chembest Research Laboratories Limited	61
Beijing HuaMeiHuLiBiological Chemical	58
China Kouting Group Limited	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
AdooQ BioScience, LLC	58
Bide Pharmatech Ltd.	60
Taizhou Yikang Chemical Co., Ltd.	58

View Latest Price from 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-22	Latrepirdine dihydrochloride 97657-92-6	$48.00		98.45%	10g	TargetMol Chemicals Inc.
	2019-07-06	2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride 97657-92-6	$2.00	1kg	99%	100kg	Career Henan Chemical Co

Latrepirdine dihydrochloride
97657-92-6
$48.00
98.45%
TargetMol Chemicals Inc.

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
97657-92-6
$2.00
99%
Career Henan Chemical Co

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Spectrum

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride(97657-92-6)¹HNMR

97657-92-6 (2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride) Related Search:

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CS-784 Latrepirdine 2HCl 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Dimebon 2HCl 2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole hydrochloride 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indoledihydrochloride DiMebone HCl DiMeboline dihydrochloride DiMebone dihydrochloride Latrepirdine dihydrochloride 2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate Dimebolin dihydrochloride hydrate Dimeboline dihydrochloride hydrate Dimebone dihydrochloride hydrate 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole,dihydrochloride 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride ISO 9001：2015 REACH Latrepirdine (Dimebolin) HCl Dimebolin dihydrochloride|||Latrepirdine|||Latrepirdine 2HCl|||Dimebolin Latrepirdine dihydrochloride, 10 mM in DMSO 2,8-Dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride , Latrepirdine 2HCl 2,3,4,5-Tetrahydro-2,8-dimethy1-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Latrepirdine 2HCl ，S1245 97657-92-6 C21H25N32HCl C21H25N32ClH C21H27Cl2N3 Inhibitors