GDC-0068
- CAS No.
- 1001264-89-6
- Chemical Name:
- GDC-0068
- Synonyms
- Ipatasertib;Cenicriviroc mesylate;RG7440;CS-543;GDC-0068;EOS-62198;patasertib;GDC-0068(RG7440);GDC-0068 USP/EP/BP;Ipatasertib (GDC-0068)
- CBNumber:
- CB52627897
- Molecular Formula:
- C24H32ClN5O2
- Molecular Weight:
- 458
- MDL Number:
- MFCD22124514
- MOL File:
- 1001264-89-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| GDC-0068 ≥98% | 18412 | 1mg | $57 |
| GDC-0068 ≥98% | 18412 | 5mg | $249 |
| GDC-0068 ≥98% | 18412 | 10mg | $437 |
| GDC-0068 ≥98% | 18412 | 25mg | $957 |
| (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone | C377870 | 50mg | $1040 |
| More product size | |||
| Melting point | >106°C (dec.) |
|---|---|
| Boiling point | 669.4±55.0 °C(Predicted) |
| Density | 1.254 |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Soluble in DMSO. |
| form | Solid |
| pka | 13.11±0.40(Predicted) |
| color | peachy |
| FDA UNII | 524Y3IB4HQ |
| NCI Drug Dictionary | ipatasertib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
GDC-0068 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18412 | GDC-0068 ≥98% | 1001264-89-6 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 18412 | GDC-0068 ≥98% | 1001264-89-6 | 5mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 18412 | GDC-0068 ≥98% | 1001264-89-6 | 10mg | $437 | 2024-03-01 | Buy |
| Cayman Chemical | 18412 | GDC-0068 ≥98% | 1001264-89-6 | 25mg | $957 | 2024-03-01 | Buy |
| TRC | C377870 | (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone | 1001264-89-6 | 50mg | $1040 | 2021-12-16 | Buy |
GDC-0068 Chemical Properties,Uses,Production
Uses
DC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively.
Uses
GDC-0068 is a highly selective AKT inhibitor targeting Akt1 , Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
Uses
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
Definition
ChEBI: (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-1-piperazinyl]-3-(propan-2-ylamino)-1-propanone is a N-arylpiperazine.
Biological Activity
gdc-0068 (rg7440) is a highly selective small molecule inhibitor of akt with ic50s of 5, 18 and 8 nm for akt1, akt2 and akt3. the pi3k-akt pathway regulates cell growth, survival and tumorigenesis. gdc-0068 binds to and blocks the activation of akt, which result in cell cycle arrest, inhibition of tumor cell proliferation and induction of tumor cell death. pi3k-akt is pathway frequently activated in tumors, thus tumors with pten or pi3k mutations, which lead to activation of akt are with high sensitivity to gdc-0068. gdc-0068 is now used for the treatment of human cancers.1. discovery and preclinical pharmacology of a selective atp-competitive akt inhibitor (gdc-0068) for the treatment of human tumors. jf blake, r xu, jr bencsik, d xiao… - journal of medicinal 20122. lin j, sampath d, nannini ma, et al: targeting activated akt with gdc-0068, a novel selective akt inhibitor that is efficacious in multiple tumor models. clin canc res 2013, 19:1760–1772.
in vivo
Ipatasertib (30 mg/kg; p.o.; single daily for 15 consecutive days) exhibits PUMA-dependent antitumor activity in HCT116 WT and PUMA/ cells xenograft nude mice model[1].
| Animal Model: | HCT116 WT and PUMA/ cells xenograft nude mice model[1]. |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage; single daily for 15 consecutive days. |
| Result: | Inhibited growth of tumors in a PUMA-dependent manner. |
target
Akt1
IC 50
Akt1: 5 nM (IC50); Akt3: 8 nM (IC50); Akt2: 18 nM (IC50); PKA: 3100 nM (IC50)
GDC-0068 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8796 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
View Lastest Price from GDC-0068 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Ipatasertib
1001264-89-6
|
US $39.00-80.00 / mg | 99.96% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | GDC-0068
1001264-89-6
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Ipatasertib
1001264-89-6
- US $39.00-80.00 / mg
- 99.96%
- TargetMol Chemicals Inc.
-
- GDC-0068
1001264-89-6
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
