ChemicalBook >> CAS DataBase List >>2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide structure

CAS No.: 332117-28-9

Chemical Name:: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

Synonyms: CS-1651;TCS 5861528;CheMbridge 5861528;Tetanus Toxin (830–844) TFA;Chembridge-5861528, 10 mM in DMSO;TCS 5861528;TCS-5861528;TCS5861528;CHEMBRIDGE-5861528;TCS-5861528;TCS5861528;N-(4-(sec-Butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide;N-[4-(butan-2-yl)phenyl]-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetamide;7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-

CBNumber:: CB32518883

Molecular Formula:: C19H23N5O3

Molecular Weight:: 369.42

MDL Number:: MFCD01993436

MOL File:: 332117-28-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

Request For Quotation

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Properties

Density	1.30±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO : 74 mg/mL (200.31 mM; Need ultrasonic and warming)
form	Powder
pka	13.75±0.70(Predicted)
color	White to off-white

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	5mg	$90	2026-04-30	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	10mg	$174	2026-04-30	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	25mg	$392	2026-04-30	Buy
Cayman Chemical	18380	TCS 5861528 ≥98%	332117-28-9	50mg	$696	2026-04-30	Buy
Usbiological	256883	TCS 5861528 Asreported	332117-28-9	10mg	$418	2026-06-03	Buy

Product number	Packaging	Price	Buy
18380	5mg	$90	Buy
18380	10mg	$174	Buy
18380	25mg	$392	Buy
18380	50mg	$696	Buy
256883	10mg	$418	Buy

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Chemical Properties, Uses, Production

Uses

TCS 5861528 is a TRPA1 channel antagonist, which may prevent development of diabetic hypersensitivity.

in vivo

Chembridge-5861528 (TCS 5861528) (30 mg/kg; i.p.; twice daily for a week) significantly attenuates development of mechanical hypersensitivity in Streptozocin (HY-13753)-induced diabetes mellitus rat model^[1].
Chembridge-5861528 (3 and 10 μg/rat; i.t.; once) attenuates Capsaicin (HY-10448)-induced blood flow increase in a dose-related fashion^[2].

Animal Model:	Male Hannover-Wistar rats, Streptozocin-induced diabetes mellitus model^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection, twice daily for a week
Result:	Significantly attenuated development of mechanical hypersensitivity as revealed by the paw pressure test (F^1,80= 31.4, P < 0.0001).

Animal Model:	Male Hannover–Wistar rats (220-260 g), Capsaicin-induced neurogenic inflammation model^[2]
Dosage:	0, 3, and 10 μg/rat
Administration:	Intrathecal injection, 20 min before Capsaicin injection
Result:	Significantly decreased the blood flow at 10 μg.

IC 50

TRPA1: 14.3 μM (IC₅₀, allyl isothiocyanate-evoked TRPA1 response); TRPA1: 18.7 μM (IC₅₀, 4-HNE-evoked TRPA1 response)

storage

Store at RT

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Suppliers

Global Suppliers ( 76)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4859	55
D&C Chemicals	+86-21-58447131	1724405207@qq.com	China	470	55
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2994	55
Pharmacodia (Beijing) Co.,Ltd	+86-400-851-9921	sales@pharmacodia.com	China	2308	55
Guangzhou QiYun Biotechnology Co., Ltd.	020-61288194 61288195	505721671@qq.com	China	3853	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
AdooQ Bioscience CHINA	60
Shanghai Lollane Biological Technology Co.,Ltd.	55
D&C Chemicals	55
Shanghai Beckham Medical Technology Co., Ltd	55
Pharmacodia (Beijing) Co.,Ltd	55
Guangzhou QiYun Biotechnology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60

View Latest Price from 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-14	Chembridge-5861528 332117-28-9	$35.00-113.00		99.97%	10g	TargetMol Chemicals Inc.

Chembridge-5861528
332117-28-9
$35.00-113.00
99.97%
TargetMol Chemicals Inc.

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide Spectrum

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide(332117-28-9)¹HNMR

332117-28-9 (2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide) Related Search:

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine 1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione potassium 3-benzyl-7-ethyl-2,6-dioxo-2,3,6,7-tetrahydropurin-1-ide 1H-Purine-1-acetamide, 2,3,6,7-tetrahydro-3,7-dimethyl-N-(4-methylphenyl)-2,6-dioxo- 7-Benzyl-1H-Purine-2,6(3H,7H)-Dione

1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-7-(phenylmethyl)-

1of2

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide TCS 5861528 CheMbridge 5861528 TCS 5861528;TCS-5861528;TCS5861528 CS-1651 CHEMBRIDGE-5861528;TCS-5861528;TCS5861528 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo- N-(4-(sec-Butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide Chembridge-5861528,Chembridge 5861528,diabetes mellitus,Transient receptor potential channels,Inhibitor,inhibit,TCS-5861528,antihypersensitivity,neurogenic inflammation,TRP Channel,TCS5861528,Chembridge5861528 N-[4-(butan-2-yl)phenyl]-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)acetamide Chembridge-5861528, 10 mM in DMSO Tetanus Toxin (830–844) TFA 332117-28-9 Inhibitors