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ChemicalBook >> CAS DataBase List >>6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Structure
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine structure
CAS No.
867017-68-3
Chemical Name:
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
Synonyms
BAY-549;TC-S 7001;Azaindole 1;Azaindole 1 (BAY-549);Rho Kinase Inhibitors;TC-S 7001(Azaindole 1);ROCK-IN-2, 10 mM in DMSO;Azaindole-1 (Rho-kinase inhibitor;RHO-KINASE INHIBITOR;RHO KINASE INHIBITOR;RHO-KINASE INHIBITOR; RHO KINASE INHIBITOR; ROCK
CBNumber:
CB72510092
Molecular Formula:
C18H13ClF2N6O
Molecular Weight:
402.79
MDL Number:
MFCD15528941
MOL File:
867017-68-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
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6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Properties

Density 1.61
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO: Soluble; Ethanol: Soluble
form A solid
pka 13.56±0.40(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19129 TC-S 7001 ≥95% 867017-68-3 500μg $129 2026-04-30 Buy
Cayman Chemical 19129 TC-S 7001 ≥95% 867017-68-3 1mg $205 2026-04-30 Buy
Cayman Chemical 19129 TC-S 7001 ≥95% 867017-68-3 5mg $574 2026-04-30 Buy
ChemScene CS-0341 BAY-549 98.16% 867017-68-3 5mg $379 2026-06-04 Buy
ChemScene CS-0341 BAY-549 98.16% 867017-68-3 10mg $607 2026-06-04 Buy
Product number Packaging Price Buy
19129 500μg $129 Buy
19129 1mg $205 Buy
19129 5mg $574 Buy
CS-0341 5mg $379 Buy
CS-0341 10mg $607 Buy

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Chemical Properties, Uses, Production

Uses

TC-S 7001 is a novel potent and highly selective azaindole-based inhibitor of Rho-kinase (ROCK). It exhibits long-acting vasodilator activity and decreases pulmonary and systemic arterial pressure in rats.

in vivo

BAY-549 (Azaindole 1) (0.03, 0.1, 0.3 mg/kg, i.v.) results in a dose-dependent and long-lasting decrease in blood pressure in anaesthetized normotensive rats. BAY-549 (3 and 10 mg/kg, p.o.) decreases blood pressure dose-dependently and persistently both in normotensive and hypertensive rats, and shows such effects even at 1 mg/kg in hypertensive rats. BAY-549 (0.1 and 0.3 mg/kg, i.v. bolus injections) causes decreased mean arterial blood pressure in a dose-related manner and only leads to a moderate and dose-independent increase in heart rate of anaesthetized dogs[1].

IC 50

ROCK-1: 0.6 nM (IC50); ROCK-2: 1.1 nM (IC50); TRK: 252 nM (IC50); FLT3: 303 nM (IC50)

storage

Store at -20°C

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Preparation Products And Raw materials

Raw materials

Preparation Products

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Suppliers

Global Suppliers ( 83)
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Supplier Advantage
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
LETOPHARM LIMITED 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
SPIRO PHARMA 55
Shanghai EFE Biological Technology Co., Ltd. 58
Guangzhou QiYun Biotechnology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Beijing Solarbio Science & Tecnology Co., Ltd. 68

View Latest Price from 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ROCK-IN-2 pictures 2026-07-14 ROCK-IN-2
867017-68-3
 $116.00-463.00 97.59% 10g TargetMol Chemicals Inc.
  • ROCK-IN-2 pictures
  • ROCK-IN-2
    867017-68-3
  • $116.00-463.00
  • 97.59%
  • TargetMol Chemicals Inc.

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Spectrum

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine(867017-68-3)1HNMR

867017-68-3 (6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine) Related Search:

5-Chloro-2,3-difluoropyridine Dichlorodifluoromethane 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine

1of2

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Rho Kinase Inhibitors 6-CHLORO-N4-[3,5-DIFLUORO-4-[(3-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-4-YL)OXY]PHENYL]PYRIMIDIN-2,4-DIAMINE TC-S 7001 Azaindole 1 RHO-KINASE INHIBITOR;RHO KINASE INHIBITOR RHO-KINASE INHIBITOR; RHO KINASE INHIBITOR; ROCK 2,4-Pyrimidinediamine, 6-chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]- 6-chloro-4-N-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]pyrimidine-2,4-diamine 6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine inhibit,Rho-kinase,Rho-associated protein kinase,Azaindole-1,ROCKIN2,Rho-associated kinase,Inhibitor,ROCK,ROCK IN 2,Azaindole1,ROK BAY-549 TC-S 7001(Azaindole 1) 6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine , BAY-549 ROCK-IN-2, 10 mM in DMSO Azaindole 1 (BAY-549) Azaindole-1 (Rho-kinase inhibitor 6-chloro-N?-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo [2,3-b] pyridin-4-yl) oxy] phenyl]-2,4-pyrimidinediamine 867017-68-3 C18H13ClF2N6O 10mg/4780