2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
![2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole Structure](CAS/GIF/937807-66-4.gif)
- CAS No.
- 937807-66-4
- Chemical Name:
- 2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
- Synonyms
- Neurodazine;Neurodazine, 10 mM in DMSO;Neurodazine, Induces neurogenesis in skeletal muscle cells;2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole;1H-Imidazole, 2-[5-(3-chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-;2-[5-(3-Chloro-phenyl)-furan-2-yl]-4,5-bis-(4-methoxy-phenyl)-1H-imidazole
- CBNumber:
- CB32518979
- Molecular Formula:
- C27H21ClN2O3
- Molecular Weight:
- 456.92
- MDL Number:
- MFCD08906055
- MOL File:
- 937807-66-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Neurodazine ≥98% (HPLC) | N6664 | 5mg | $177 |
| Neurodazine ≥98% (HPLC) | N6664 | 25mg | $489 |
| Neurodazine ≥98% | 13224 | 5mg | $134 |
| Neurodazine ≥98% | 13224 | 10mg | $169 |
| Neurodazine ≥98% | 13224 | 25mg | $376 |
| Boiling point | 661.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.252±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >20mg/mL |
| form | powder, yellow |
| pka | 12.84±0.10(Predicted) |
| color | Beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | 1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30) |
| InChIKey | FEEOFPAEDSMOTO-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1)-c2nc([nH]c2-c3ccc(OC)cc3)-c4ccc(o4)-c5cccc(Cl)c5 |
| UNSPSC Code | 12352203 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H318-H413 | |||||||||
| Precautionary statements | P280-P301+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-41 | |||||||||
| Safety Statements | 26-39-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 1 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 4 Eye Dam. 1 |
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| NFPA 704 |
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2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N6664 | Neurodazine ≥98% (HPLC) | 937807-66-4 | 5mg | $177 | 2026-04-30 | Buy |
| Sigma-Aldrich | N6664 | Neurodazine ≥98% (HPLC) | 937807-66-4 | 25mg | $489 | 2026-04-30 | Buy |
| Cayman Chemical | 13224 | Neurodazine ≥98% | 937807-66-4 | 5mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 13224 | Neurodazine ≥98% | 937807-66-4 | 10mg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 13224 | Neurodazine ≥98% | 937807-66-4 | 25mg | $376 | 2026-04-30 | Buy |
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole Chemical Properties,Uses,Production
Description
Neurodazine (937807-66-4) was able to induce neurogenesis of non-pluripotent myoblasts and cells derived from mature, human skeletal muscle (using 2 μM neurodazine). It was able to upregulate genes involved in neurogenesis (particularly B-cell translocation gene 2) without affecting those involved in myogenesis.
Uses
Neurodazine induces neurogenesis in mature skeletal muscle cells, via non-pluripotent C2C12 myoblasts.
Definition
ChEBI: 2-[5-(3-chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole is a member of imidazoles.
General Description
A cell-permeable trisubstituted imidazole compound that induces neurogenesis of non-pluripotent C2C12 myoblasts as well as cells derived from mature human skeletal muscle cultures (2 μM for 7-10 days). Shown to preferentially upregulate genes involved in neurogenesis, but not those pertaining to myogenesis, in C2C12 myoblasts.
Biochem/physiol Actions
Neurodazine is a promoter of neurogenesis. It induces a generation of new nerve cells from skeletal muscle fibers both immature, differentiated myotubes and mature skeletal muscle. Neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells (neurogenesis). In addition, in conjunction with a microtubule-destabilizing agent, Neurodazine allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Neurodazine is a potential alternative approach to using stem cells.
storage
Store at +4°C
References
[1] DARREN R. WILLIAMS. Synthetic Small Molecules that Induce Neurogenesis in Skeletal Muscle[J]. Journal of the American Chemical Society, 2007, 129 30: 9258-9259. DOI:10.1021/ja072817z
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15815 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9739 | 55 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5037 | 58 |
View Lastest Price from 2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Neurodazine
937807-66-4
|
$52.00-118.00 | 98.03% | 10g | TargetMol Chemicals Inc. |
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- Neurodazine
937807-66-4
- $52.00-118.00
- 98.03%
- TargetMol Chemicals Inc.
