PF 4800567 hydrochloride
- CAS No.
- 1188296-52-7
- Chemical Name:
- PF 4800567 hydrochloride
- Synonyms
- PF 4800567;PF 4800567;PF-4800567;PF 4800567 hydrochloride;PF-4800567, 10 mM in DMSO;Casein Kinase I Inhibitor III, PF-4800567;Casein Kinase,PF4800567,inhibit,PF-4800567,PF 4800567,Inhibitor;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine;3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-;3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride
- CBNumber:
- CB32561076
- Molecular Formula:
- C17H18ClN5O2
- Molecular Weight:
- 359.81
- MDL Number:
- MFCD22123245
- MOL File:
- 1188296-52-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Casein Kinase I Inhibitor III, PF-4800567 The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat | 218719 | 5 mg | $324 |
| PF-4800567 ≥98% | 19171 | 1mg | $37 |
| PF-4800567 ≥98% | 19171 | 5mg | $142 |
| PF-4800567 ≥98% | 19171 | 10mg | $231 |
| PF-4800567 ≥98% | 19171 | 25mg | $530 |
| More product size | |||
| Boiling point | 592.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml |
| pka | 4.01±0.30(Predicted) |
| form | A crystalline solid |
| color | Light yellow to yellow |
| InChI | 1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21) |
| InChIKey | AUMDBEHGJRZSOO-UHFFFAOYSA-N |
| SMILES | NC1=NC=NC2=C1C(COC3=CC=CC(Cl)=C3)=NN2C4CCOCC4 |
| FDA UNII | GEE72DRC63 |
| UNSPSC Code | 12352200 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 2 |
| Storage Class | 11 - Combustible Solids |
PF 4800567 hydrochloride price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 218719 | Casein Kinase I Inhibitor III, PF-4800567 The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat | 1188296-52-7 | 5 mg | $324 | 2026-03-19 | Buy |
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 5mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 10mg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 25mg | $530 | 2024-03-01 | Buy |
PF 4800567 hydrochloride Chemical Properties,Uses,Production
Description
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. It blocks CK1ε-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells. PF-4800567 has been used in the study of the CK1 enzymes in the regulation of circadian rhythm and is also reported to have neuroprotective effects.
Uses
PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
Definition
ChEBI: PF-4800567 is a pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidin-4-amine which is substituted at positions 1 and 3 by tetrahydro-2H-pyran-4-yl and (m-chlorophenoxy)methyl groups, respectively. It is a selective inhibitor of the epsilon isoform of casein kinase 1 (CK1epsilon). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a pyrazolopyrimidine, a member of monochlorobenzenes, an aromatic ether and a member of oxanes.
in vivo
PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice[1].
IC 50
CKIδ: 711 nM (IC50)
References
[1] KEVIN M WALTON. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 330 2: 430-439. DOI: 10.1124/jpet.109.151415
[2] QING-JUN MENG. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010: 15240-15245. DOI: 10.1073/pnas.1005101107
[3] DANIEL I. PEREZ Ana M Carmen Gil. Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases[J]. Medicinal Research Reviews, 2011, 31 6: 924-954. DOI: 10.1002/med.20207
PF 4800567 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30227 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 39999 | 60 |
View Lastest Price from PF 4800567 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | PF-4800567
1188296-52-7
|
US $38.00-137.00 / mg | 99.74% | 10g | TargetMol Chemicals Inc. |
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- PF-4800567
1188296-52-7
- US $38.00-137.00 / mg
- 99.74%
- TargetMol Chemicals Inc.
