| Identification | Back Directory | [Name]
PF 4800567 hydrochloride | [CAS]
1188296-52-7 | [Synonyms]
PF 4800567
PF 4800567;PF-4800567
PF 4800567 hydrochloride
3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-
3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride | [Molecular Formula]
C17H18ClN5O2 | [MDL Number]
MFCD22123245 | [MOL File]
1188296-52-7.mol | [Molecular Weight]
359.81 |
| Chemical Properties | Back Directory | [Boiling point ]
592.9±50.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
4.01±0.30(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21) | [InChIKey]
AUMDBEHGJRZSOO-UHFFFAOYSA-N | [SMILES]
NC1=NC=NC2=C1C(COC3=CC=CC(Cl)=C3)=NN2C4CCOCC4 |
| Hazard Information | Back Directory | [Description]
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. It blocks CK1ε-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells. PF-4800567 has been used in the study of the CK1 enzymes in the regulation of circadian rhythm and is also reported to have neuroprotective effects. | [Uses]
PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. | [Definition]
ChEBI: PF-4800567 is a pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidin-4-amine which is substituted at positions 1 and 3 by tetrahydro-2H-pyran-4-yl and (m-chlorophenoxy)methyl groups, respectively. It is a selective inhibitor of the epsilon isoform of casein kinase 1 (CK1epsilon). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a pyrazolopyrimidine, a member of monochlorobenzenes, an aromatic ether and a member of oxanes. | [in vivo]
PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice[1]. | [IC 50]
CKIδ: 711 nM (IC50) | [storage]
Store at -20°C | [References]
[1] KEVIN M WALTON. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 330 2: 430-439. DOI: 10.1124/jpet.109.151415
[2] QING-JUN MENG. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010: 15240-15245. DOI: 10.1073/pnas.1005101107
[3] DANIEL I. PEREZ Ana M Carmen Gil. Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases[J]. Medicinal Research Reviews, 2011, 31 6: 924-954. DOI: 10.1002/med.20207 |
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