ATB-343
- CAS No.
- 1000700-26-4
- Chemical Name:
- ATB-343
- Synonyms
- ATB-343;ATB-343 Exclusive;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester
- CBNumber:
- CB32590306
- Molecular Formula:
- C28H20ClNO4S3
- Molecular Weight:
- 566.11
- MDL Number:
- MOL File:
- 1000700-26-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| ATB-343 ≥98% | 13045 | 1mg | $32 |
| ATB-343 ≥98% | 13045 | 5mg | $152 |
| ATB-343 ≥98% | 13045 | 10mg | $272 |
| ATB-343 ≥98% | 13045 | 50mg | $1038 |
| ATB-343 | CS-0003709 | 1mg | $69 |
ATB-343 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13045 | ATB-343 ≥98% | 1000700-26-4 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 13045 | ATB-343 ≥98% | 1000700-26-4 | 5mg | $152 | 2026-04-30 | Buy |
| Cayman Chemical | 13045 | ATB-343 ≥98% | 1000700-26-4 | 10mg | $272 | 2026-04-30 | Buy |
| Cayman Chemical | 13045 | ATB-343 ≥98% | 1000700-26-4 | 50mg | $1038 | 2026-04-30 | Buy |
| ChemScene | CS-0003709 | ATB-343 | 1000700-26-4 | 1mg | $69 | 2026-06-04 | Buy |
ATB-343 Chemical Properties,Uses,Production
Uses
ATB-343 is a hybrid molecule of the NSAID indomethacinan and an H2S donor.
Biological Activity
atb-343, also named as indomethacin, is an h2s-releasing derivative of indomethacin [1].hydrogen sulfide (h2s) is a newly recognized signaling molecule with potent cytoprotective actions. hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation [2].
in vitro
indomethacin enhanced the nk cell activity in vitro by blocking the prostaglandin production of monocytes [3].
in vivo
in rats, oral administration of atb-343 significantly inhibited gastric prostaglandin synthesis and systemic cox-1 activity [1]. indomethacin was a potent inhibitor of prostaglandin synthesis. indomethacin suppressed in vivo thyroid hormone secretion and cholera toxin-induced intestinal fluid accumulation. indomethacin in submicromolar concentrations inhibited cyclic amp-dependent protein kinase and endogenous protein phosphorylation [4].
References
[1] wallace j l. hydrogen sulfide-releasing anti-inflammatory drugs[j]. trends in pharmacological sciences, 2007, 28(10): 501-505.
[2] wallace j l. physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract[j]. antioxidants & redox signaling, 2010, 12(9): 1125-1133.
[3] pedersen b k, oxholm p, klarlund k. characterization of the in vivo and in vitro effects of indomethacin on human natural killer cell activity[j]. allergy, 1986, 41(7): 532-536.
[4] kantor h s, hampton m. indomethacin in submicromolar concentrations inhibits cyclic amp-dependent protein kinase[j]. 1978.
[5] rogers j, kirby l c, hempelman s r, et al.
ATB-343 Preparation Products And Raw materials
Raw materials
Preparation Products
ATB-343 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44924 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Cayman Chemical Company | -- | sales@caymanchem.com | China | 6808 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6575 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6245 | 58 |
| Shanghai Shitang Industrial Co., Ltd. | -- | CHINA | 3405 | 58 | |
| Guangzhou Yiran Biotechnology Co., Ltd. | -- | CHINA | 6841 | 58 |
