5-(TrifluoroMethyl)benzoxazole
- CAS No.
- 1267217-46-8
- Chemical Name:
- 5-(TrifluoroMethyl)benzoxazole
- Synonyms
- 5-(TrifluoroMethyl)benzo[d]oxazole;5-(TrifluoroMethyl)benzoxazole;Benzoxazole, 5-(trifluoromethyl)-;5-(trifluoromethyl)-1,3-benzoxazole;5-(Trifluoromethyl)-1,3-benzoxazole95%;5-(Trifluoromethyl)-1,3-benzoxazole 95%
- CBNumber:
- CB32596944
- Molecular Formula:
- C8H4F3NO
- Molecular Weight:
- 187.12
- MDL Number:
- MFCD19374815
- MOL File:
- 1267217-46-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
5-(TrifluoroMethyl)benzoxazole price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC300509 | 5-(Trifluoromethyl)-1,3-benzoxazole 95% | 1267217-46-8 | 250mg | $116 | 2026-06-04 | Buy |
| Apolloscientific | PC300509 | 5-(Trifluoromethyl)-1,3-benzoxazole 95% | 1267217-46-8 | 1g | $232 | 2026-06-04 | Buy |
| ACHEMBLOCK | U139980 | 5-(Trifluoromethyl)benzoxazole 97% | 1267217-46-8 | 1G | $240 | 2026-05-27 | Buy |
| ACHEMBLOCK | U139980 | 5-(Trifluoromethyl)benzoxazole 97% | 1267217-46-8 | 5G | $605 | 2026-05-27 | Buy |
| ACHEMBLOCK | U139980 | 5-(Trifluoromethyl)benzoxazole 97% | 1267217-46-8 | 25G | $2555 | 2026-05-27 | Buy |
5-(TrifluoroMethyl)benzoxazole Chemical Properties, Uses, Production
Synthesis
400-99-7
122-51-0
1267217-46-8
The general procedure for the synthesis of 5-trifluoromethylbenzoxazole from 2-nitro-4-trifluoromethylphenol and triethyl orthoformate was as follows: 2-nitro-4-(trifluoromethyl)phenol (500 mg, 2.41 mmol) and a palladium/carbon catalyst (200 mg) were added to ethanol (10 ml) at 0 °C and under argon protection. After hydrogen was passed to replace the air in the reaction system, the reaction was stirred at room temperature overnight. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure. To the concentrated residue, triethyl orthoformate (2.4 ml, 14.5 mmol) was added and p-toluenesulfonic acid monohydrate (23 mg, 0.12 mmol) was added dropwise as a catalyst. The reaction mixture was heated to reflux and stirred for 3 hours under argon protection. Upon completion of the reaction, the reaction solution was concentrated to dryness. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to give 5-trifluoromethylbenzoxazole (182 mg, 40% yield).
References
[1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0108
5-(TrifluoroMethyl)benzoxazole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| 3A Chemicals | 400-668-9898 | service@3achem.com | China | 20535 | 58 |
| Shanghai Thunder Biological Technology Co., Ltd. | 18621609968 | 1162686636@qq.com | China | 1031 | 58 |
| Allfluoro Pharmaceutical Company Limited | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11380 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
