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4-Hydroxy-3-nitrobenzotrifluoride

4-Hydroxy-3-nitrobenzotrifluoride structure

CAS No.: 400-99-7

Chemical Name:: 4-Hydroxy-3-nitrobenzotrifluoride

Synonyms: 2-NITRO-4-(TRIFLUOROMETHYL)PHENOL;4-Hydroxy-3-nitroben;alpha,alpha,alpha-trifluoro-2;2-nitro-4-trifluoromethlphenol;5-Nitro-2-trifluoromethyl-phenol;2-Nitro-4-(trifluormethyl)phenol;4-HYDROXY-3-NITROBENZOTRIFLUORIDE;2-nitro-4-(trifluoromethyl)-pheno;4-HYDROXY-3-NITROBENZOTRIFLUOROIDE;3-nitro-4-hydroxy-benzotrifluoride

CBNumber:: CB2254964

Molecular Formula:: C7H4F3NO3

Molecular Weight:: 207.11

MDL Number:: MFCD00009791

MOL File:: 400-99-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:04:08

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4-Hydroxy-3-nitrobenzotrifluoride Properties

Boiling point	92-94 °C12 mm Hg(lit.)
Density	1.473 g/mL at 25 °C(lit.)
refractive index	n20/D 1.504(lit.)
Flash point	203 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
pka	5.53±0.14(Predicted)
color	Yellow to orange
BRN	2215510
InChI	1S/C7H4F3NO3/c8-7(9,10)4-1-2-6(12)5(3-4)11(13)14/h1-3,12H
InChIKey	XZEDEVRSUANQEM-UHFFFAOYSA-N
SMILES	Oc1ccc(cc1[N+]([O-])=O)C(F)(F)F
CAS DataBase Reference	400-99-7(CAS DataBase Reference)
FDA UNII	CU9AQU8UAL
EPA Substance Registry System	Phenol, 2-nitro-4-(trifluoromethyl)- (400-99-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-36

WGK Germany

RTECS

GP2984950

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29089990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity

LD50 ipr-mus: 800 mg/kg JPMSAE 57,1763,68

NFPA 704

	1
2		0

4-Hydroxy-3-nitrobenzotrifluoride price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	238759	2-Nitro-4-(trifluoromethyl)phenol 99%	400-99-7	1G	$49	2023-01-07	Buy
TCI Chemical	N0779	2-Nitro-4-(trifluoromethyl)phenol >98.0%(GC)(T)	400-99-7	1g	$40	2026-04-30	Buy
TCI Chemical	N0779	2-Nitro-4-(trifluoromethyl)phenol >98.0%(GC)(T)	400-99-7	5g	$130	2026-04-30	Buy
Usbiological	285484	2-Nitro-4-(Trifluoromethyl)phenol Asreported	400-99-7	2g	$333	2026-06-03	Buy
Usbiological	285484	2-Nitro-4-(Trifluoromethyl)phenol Asreported	400-99-7	5g	$446	2026-06-03	Buy

Product number	Packaging	Price	Buy
238759	1G	$49	Buy
N0779	1g	$40	Buy
N0779	5g	$130	Buy
285484	2g	$333	Buy
285484	5g	$446	Buy

4-Hydroxy-3-nitrobenzotrifluoride Chemical Properties, Uses, Production

Uses

2-Nitro-4-(trifluoromethyl)phenol has been used in the synthesis of 2-methyl-2-[2-nitro-4-(trifluoromethyl)phenoxy]propionic acid ethyl ester.

General Description

2-Nitro-4-(trifluoromethyl)phenol is the major product of solution phase photodecomposition of fluorodifen.

Safety Profile

Moderately toxic byintraperitoneal route. When heated to decomposition itemits toxic vapors of NOx and Fí.

Synthesis

139-07-1

121-17-5

400-99-7

Example 1: 400 mL of methanol, 20 g of dodecyldimethylbenzylammonium chloride and 180 g of 4-chloro-3-nitrobenzotrifluoride were added to a reaction flask with stirring turned on. Subsequently, 400 g of 50% sodium hydroxide solution was slowly added dropwise, with the dropwise acceleration controlled to raise the reaction temperature to 70°C in about 20 minutes. The reaction mixture was continued stirring at 65°C for 4 hours. Upon completion of the reaction, the mixture was cooled in an ice water bath and the pH was adjusted with concentrated hydrochloric acid to 3. 2-Nitro-4-trifluoromethylphenol was isolated by steam distillation, and about 50 mL of concentrated hydrochloric acid was added to the receiver to facilitate phase separation. After gas chromatographic analysis, 156 g of 2-nitro-4-trifluoromethylphenol was obtained with a purity of >98.5% and a yield of 91% of the theoretical value. The boiling point of the product was 92 °C-95 °C (15 mmHg) and the refractive index nD20 was 1.5020.

References

[1] Patent: US4225731, 1980, A

4-Hydroxy-3-nitrobenzotrifluoride synthesis

Synthesis of 4-Hydroxy-3-nitrobenzotrifluoride from Dodecyldimethylbenzylammonium chloride and 4-Chloro-3-nitrobenzotrifluoride

4-Hydroxy-3-nitrobenzotrifluoride Preparation Products And Raw materials

Raw materials

4-Amino-3-nitrobenzotrifluoride Sodium hydroxide Hydrochloric acid 4-Chloro-3-nitrobenzotrifluoride Methanol

2-Methoxyethanol 4-Trifluoromethylphenol Dodecyldimethylbenzylammonium chloride

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Preparation Products

4-Fluoro-3-nitrobenzotrifluoride 2-amino-alpha,alpha,alpha-trifluoro-p-creso BUTTPARK 120\07-77

4-Hydroxy-3-nitrobenzotrifluoride Suppliers

Global Suppliers ( 219)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62

View Latest Price from 4-Hydroxy-3-nitrobenzotrifluoride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-07	4-Hydroxy-3-nitrobenzotrifluoride 400-99-7	$1.00-12.00	1KG	99%	1000KG	Shaanxi Dideu Medichem Co. Ltd
2026-03-20	4-Hydroxy-3-nitrobenzotrifluoride 400-99-7		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-02-02	4-Hydroxy-3-nitrobenzotrifluoride 400-99-7		50mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd

4-Hydroxy-3-nitrobenzotrifluoride
400-99-7
$1.00-12.00
99%
Shaanxi Dideu Medichem Co. Ltd

4-Hydroxy-3-nitrobenzotrifluoride
400-99-7
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Hydroxy-3-nitrobenzotrifluoride
400-99-7
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

4-Hydroxy-3-nitrobenzotrifluoride Spectrum

4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)MS 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)¹HNMR 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)¹³CNMR 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)IR1 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)Raman

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2-nitro-4-(trifluoromethyl)-pheno 4-HYDROXY-3-NITROBENZOTRIFLUORIDE 4-HYDROXY-3-NITROBENZOTRIFLUOROIDE 2-Nitro-4-(trifluormethyl)phenol 2-nitro-alpha,alpha,alpha-trifluoro-p-creso 2-nitro-alpha,alpha,alpha-trifluoro-p-cresol alpha,alpha,alpha-trifluoro-2 5-Nitro-2-trifluoromethyl-phenol 4-Hydroxy-3-nitroben alpha,alpha,alpha-trifluoro-2-nitro-p-cresol 2-nitro-4-trifluoromethlphenol 4-Hydroxy-3-nitrobenzotrifluoride 97% 4-Hydroxy-3-nitrobenzotrifluoride97% 2-Nitro-4-(trifluoromethyl)phenol, 2-Nitro-alpha,alpha,alpha-trifluoro-p-cresol 3-nitro-4-hydroxy-benzotrifluoride 2-Nitro-4-(trifluoroMethyl)phenol, 97+% 2-Nitro-4-(trifluoromethyl)phenol> Phenol, 2-nitro-4-(trifluoromethyl)- 2-NITRO-4-(TRIFLUOROMETHYL)PHENOL 400-99-7 Oxygen Compounds Phenols Organic Building Blocks Building Blocks Phenol&Thiophenol&Mercaptan Organic Building Blocks Oxygen Compounds Phenols