UNBS-5162
- CAS No.
- 956590-23-1
- Chemical Name:
- UNBS-5162
- Synonyms
- CS-1759;UNBS-5162;Uunbs-5162;UNBS-5162, >=98%;UNBS 5162; UNBS-5162;UNBS5162, 10 mM in DMSO;[2-[2-(dimethylamino)ethyl]-1,3-dioxobenzo[de]isoquinolin-5-yl]urea;1-(2-(2-(Dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea;Urea, N-[2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]-;1-(2-(2-(dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea UNBS-5162
- CBNumber:
- CB32658208
- Molecular Formula:
- C17H18N4O3
- Molecular Weight:
- 326.35
- MDL Number:
- MFCD22380608
- MOL File:
- 956590-23-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| UNBS5162 ≥98% (HPLC) | SML2797 | 5MG | $111 |
| UNBS5162 ≥98% (HPLC) | SML2797 | 25MG | $302.6 |
| UNBS5162 ≥98% | 17739 | 5mg | $90 |
| UNBS5162 ≥98% | 17739 | 10mg | $168 |
| UNBS5162 ≥98% | 17739 | 25mg | $370 |
| Boiling point | 526.4±35.0 °C(Predicted) |
|---|---|
| Density | 1.389±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| pka | 13.50±0.20(Predicted) |
| color | Light yellow to yellow |
| InChI | 1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24) |
| InChIKey | WCKZRLOUKYFJDY-UHFFFAOYSA-N |
| SMILES | [n]1([c](c2c3c([c]1=O)cccc3cc(c2)NC(=O)N)=O)CCN(C)C |
| FDA UNII | JY9JF7D78N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
UNBS-5162 price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2797 | UNBS5162 ≥98% (HPLC) | 956590-23-1 | 5MG | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2797 | UNBS5162 ≥98% (HPLC) | 956590-23-1 | 25MG | $302.6 | 2026-04-30 | Buy |
| Cayman Chemical | 17739 | UNBS5162 ≥98% | 956590-23-1 | 5mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 17739 | UNBS5162 ≥98% | 956590-23-1 | 10mg | $168 | 2026-04-30 | Buy |
| Cayman Chemical | 17739 | UNBS5162 ≥98% | 956590-23-1 | 25mg | $370 | 2026-04-30 | Buy |
UNBS-5162 Chemical Properties,Uses,Production
Uses
UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.
Biological Activity
UNBS5162, an amonafide (naphthalimide) derivative, is a potent antitumor agent th at inhibits tumor proliferation, progression and invasiveness. UNBS5162 is a pan-antagonist of CXCL chemokine expression. It appears th at UNBS5162 inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.
in vivo
UNBS5162 (20 mg/kg, i.v.) increases the therapeutic benefits of taxol in vivo in the orthotopic human PC-3 prostate cancer model[1].
IC 50
CXCL
References
[1] Mijatovic T, et al. UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Neoplasia. 2008 Jun;10(6):573-86. DOI:10.1593/neo.08290
[2] Tina Mahieu, et al. UNBS5162: A novel naphthalimide derivative with potent pro-autophagic effects in human cancer cells. Cancer Research, 2007 May; 67(9) Supplement.
[3] He D, et al. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. Mol Med Rep. 2018 Jan;17(1):549-555. DOI:10.3892/mmr.2017.7893
UNBS-5162 Preparation Products And Raw materials
Raw materials
Preparation Products
UNBS-5162 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9935 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
