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UNBS-5162

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:UNBS5162；UNBS-5162;UNBS 5162
CAS:956590-23-1
Purity:99.97% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:UNBS-5162
CAS:956590-23-1
Purity:99% Package:5KG;1KG Remarks:UNBS-5162
Company Name: InvivoChem
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Products Intro: Product Name:UNBS5162
CAS:956590-23-1
Purity:98% Package:5mg Remarks:V27842
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
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Products Intro: Product Name:UNBS-5162
CAS:956590-23-1
Company Name: Aladdin Scientific
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Products Intro: Product Name:UNBS5162
CAS:956590-23-1
Purity:98% Package:$69.9/5mg;$205.9/1mg;$259.9/25mg;$304.9/10mg;$602.9/50mg;$805.9/100mg;Bulk packa Remarks:98%
UNBS-5162 Basic information
Product Name:UNBS-5162
Synonyms:UNBS-5162;CS-1759;UNBS 5162; UNBS-5162;1-(2-(2-(Dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea;1-(2-(2-(dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea UNBS-5162;UNBS-5162, >=98%;[2-[2-(dimethylamino)ethyl]-1,3-dioxobenzo[de]isoquinolin-5-yl]urea;Uunbs-5162
CAS:956590-23-1
MF:C17H18N4O3
MW:326.35
EINECS:
Product Categories:Inhibitors
Mol File:956590-23-1.mol
UNBS-5162 Structure
UNBS-5162 Chemical Properties
Boiling point 526.4±35.0 °C(Predicted)
density 1.389±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in DMSO
form crystalline solid
pka13.50±0.20(Predicted)
color Light yellow to yellow
InChI1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24)
InChIKeyWCKZRLOUKYFJDY-UHFFFAOYSA-N
SMILES[n]1([c](c2c3c([c]1=O)cccc3cc(c2)NC(=O)N)=O)CCN(C)C
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
UNBS-5162 Usage And Synthesis
UsesUNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity.
Biological ActivityUNBS5162, an amonafide (naphthalimide) derivative, is a potent antitumor agent th at inhibits tumor proliferation, progression and invasiveness. UNBS5162 is a pan-antagonist of CXCL chemokine expression. It appears th at UNBS5162 inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.
in vivo

UNBS5162 (20 mg/kg, i.v.) increases the therapeutic benefits of taxol in vivo in the orthotopic human PC-3 prostate cancer model[1].

IC 50CXCL
References[1] Mijatovic T, et al. UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Neoplasia. 2008 Jun;10(6):573-86. DOI:10.1593/neo.08290
[2] Tina Mahieu, et al. UNBS5162: A novel naphthalimide derivative with potent pro-autophagic effects in human cancer cells. Cancer Research, 2007 May; 67(9) Supplement.
[3] He D, et al. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. Mol Med Rep. 2018 Jan;17(1):549-555. DOI:10.3892/mmr.2017.7893
UNBS-5162 Preparation Products And Raw materials
Tag:UNBS-5162(956590-23-1) Related Product Information
URMC-099 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one 2,9-bis(3-aminophenyl)anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2-aminoethyl)-6-(dimethylamino)- 1H-benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-phenyl- N-Desmethylamonafide