R 112 (pharMaceutical)
- CAS No.
- 575474-82-7
- Chemical Name:
- R 112 (pharMaceutical)
- Synonyms
- R112, >98%;R-112; R 112;(E)-Elafibranor;R112, 10 mM in DMSO;R 112 (pharMaceutical);3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol;Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-;3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol;Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit
- CBNumber:
- CB32667633
- Molecular Formula:
- C16H13FN4O2
- Molecular Weight:
- 312.3
- MDL Number:
- MFCD12922519
- MOL File:
- 575474-82-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 552.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.494±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM) |
| form | A crystalline solid |
| pka | 9.48±0.10(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | Y7W5AL9KHB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
R 112 (pharMaceutical) price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22929 | R112 ≥98% | 575474-82-7 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 22929 | R112 ≥98% | 575474-82-7 | 5mg | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 22929 | R112 ≥98% | 575474-82-7 | 10mg | $165 | 2026-04-30 | Buy |
| Cayman Chemical | 22929 | R112 ≥98% | 575474-82-7 | 25mg | $310 | 2026-04-30 | Buy |
| ChemScene | CS-5235 | R112 98.90% | 575474-82-7 | 5mg | $103 | 2026-06-04 | Buy |
R 112 (pharMaceutical) Chemical Properties, Uses, Production
Description
R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; ) and decreases cytokine levels in cultured human mast cells.
Uses
R 112 is Syk inhibitor. It can be used in biological study and therapeutic use of application of cultured human mast cells (CHMC) for design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.
References
[1] ALEXANDER B. ROSSI BA. Identification of the Syk kinase inhibitor R112 by a human mast cell screen[J]. Journal of Allergy and Clinical Immunology, 2006, 118 3: Pages 749-755. DOI: 10.1016/j.jaci.2006.05.023
R 112 (pharMaceutical) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
