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ChemicalBook >> CAS DataBase List >> R 112 (pharMaceutical)

R 112 (pharMaceutical)

$10 - $1996
Product name: R 112 (pharMaceutical)
CAS: 575474-82-7
MF: C16H13FN4O2
MW: 312.3
EINECS:
MDL Number:MFCD12922519
Synonyms:R 112 (pharMaceutical);Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-;(E)-Elafibranor;3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol;R-112; R 112;R112, >98%;Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit;3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol

Price51 Properties Safety Information Description

51 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
Arctom
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC

Package

2mg
250mg
10mM*1mLinDMSO(Solution)
10mM*1mLinDMSO
50.00mg
100.00mg
250.00mg
10mM*1mLinDMSO(Solid+Solvent)
1mg
5mg
10mg
25mg
50mg
100mg
1G

Manufactureraablocks
Product numberAA00ECBQ
Product descriptionR112 99%
Packaging1mg
Price$10
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00ECBQ
Product descriptionR112 99%
Packaging5mg
Price$18
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00ECBQ
Product descriptionR112 ≥98%
Packaging25mg
Price$51
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00ECBQ
Product descriptionR112 ≥98%
Packaging50mg
Price$85
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA00ECBQ
Product descriptionR112 ≥98%
Packaging100mg
Price$144
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberO33975
Product descriptionR112 98%
Packaging25MG
Price$45
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberO33975
Product descriptionR112 98%
Packaging100MG
Price$105
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberO33975
Product descriptionR112 98%
Packaging1G
Price$425
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number4119CR
Product descriptionCID9904854
Packaging25mg
Price$1416
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013741
Product description3,3'-[(5-FLUORO-2,4-PYRIMIDINEDIYL)DIIMINO]BIS-PHENOL (R112) 95.00%
Packaging5MG
Price$495.21
Updated2021-12-16
Buy

ManufacturerArctom
Product numberHY-16420
Product descriptionR112 98.90%
Packaging50mg
Price$471
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-16420
Product descriptionR112 98.90%
Packaging100mg
Price$727
Updated2026-05-26
Buy

ManufacturerArctom
Product numberSLK-S6519
Product descriptionR112 99.56%
Packaging25mg
Price$283
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-16420
Product descriptionR112 98.90%
Packaging25mg
Price$295
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-16420
Product descriptionR112 98.90%
Packaging10mg
Price$157
Updated2026-05-26
Buy

ManufacturerArctom
Product numberSLK-S6519
Product descriptionR112 99.56%
Packaging5mg
Price$93
Updated2026-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA00ECBQ	R112 99%	1mg	$10	2026-05-28	Buy
aablocks	AA00ECBQ	R112 99%	5mg	$18	2026-05-28	Buy
aablocks	AA00ECBQ	R112 ≥98%	25mg	$51	2026-05-28	Buy
aablocks	AA00ECBQ	R112 ≥98%	50mg	$85	2026-05-28	Buy
aablocks	AA00ECBQ	R112 ≥98%	100mg	$144	2026-05-28	Buy
ACHEMBLOCK	O33975	R112 98%	25MG	$45	2026-05-27	Buy
ACHEMBLOCK	O33975	R112 98%	100MG	$105	2026-05-27	Buy
ACHEMBLOCK	O33975	R112 98%	1G	$425	2026-05-27	Buy
AK Scientific	4119CR	CID9904854	25mg	$1416	2021-12-16	Buy
American Custom Chemicals Corporation	API0013741	3,3'-[(5-FLUORO-2,4-PYRIMIDINEDIYL)DIIMINO]BIS-PHENOL (R112) 95.00%	5MG	$495.21	2021-12-16	Buy
Arctom	HY-16420	R112 98.90%	50mg	$471	2026-05-26	Buy
Arctom	HY-16420	R112 98.90%	100mg	$727	2026-05-26	Buy
Arctom	SLK-S6519	R112 99.56%	25mg	$283	2026-05-26	Buy
Arctom	HY-16420	R112 98.90%	25mg	$295	2026-05-26	Buy
Arctom	HY-16420	R112 98.90%	10mg	$157	2026-05-26	Buy
Arctom	SLK-S6519	R112 99.56%	5mg	$93	2026-05-26	Buy

Next Last

Properties

Boiling point :552.0±60.0 °C(Predicted)
Density :1.494±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM)
form :A crystalline solid
pka :9.48±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P330	Rinse mouth.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

R112 is an inhibitor of spleen tyrosine kinase (Syk; IC₅₀ = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (K_i = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC₅₀s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC₅₀ value of 490 nM. R112 inhibits the production of leukotriene C₄ (LTC₄; ) and decreases cytokine levels in cultured human mast cells.

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Suppliers and manufacturers

Haoyuan Chemexpress Co., Ltd. AdooQ Bioscience CHINA Shanghai JiYi Biotechnology Co. Ltd. Shanghaizehan biopharma technology co., Ltd. SPIRO PHARMA Shanghai EFE Biological Technology Co., Ltd. Guangzhou QiYun Biotechnology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. ShangHai Biochempartner Co.,Ltd Shanghai Chaolan Chemical Technology Center

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R 112 (pharMaceutical)

Properties

Safety Information

Description

Related product price

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