HIF-1alpha/2alpha Inhibitor
- CAS No.
- 329932-55-0
- Chemical Name:
- HIF-1alpha/2alpha Inhibitor
- Synonyms
- FM19G11;FM 19G11 NEW;FM19G11 >=98% (HPLC);HIF-1alpha/2alpha Inhibitor;HIF-1α/2α Inhibitor IV, FM19G11;2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate;[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate;3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester;Benzoic acid, 3-[(2,4-dinitrobenzoyl)amino]-, 2-(4-methylphenyl)-2-oxoethyl ester
- CBNumber:
- CB32668403
- Molecular Formula:
- C23H17N3O8
- Molecular Weight:
- 463.4
- MDL Number:
- MFCD01174289
- MOL File:
- 329932-55-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| FM19G11 ≥98% (HPLC) | F8807 | 5mg | $186 |
| FM19G11 ≥98% (HPLC) | F8807 | 25mg | $539 |
| FM19G11 | Axon2959 | 5mg | $104.5 |
| FM19G11 | Axon2959 | 25mg | $357.5 |
| FM19G11 | AA00CMPZ | 1mg | $55 |
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: ≥40mg/mL |
| form | powder |
| color | off-white to light brown |
| InChI | 1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28) |
| InChIKey | XVUOIWIIQVGWAJ-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
HIF-1alpha/2alpha Inhibitor price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F8807 | FM19G11 ≥98% (HPLC) | 329932-55-0 | 5mg | $186 | 2026-04-30 | Buy |
| Sigma-Aldrich | F8807 | FM19G11 ≥98% (HPLC) | 329932-55-0 | 25mg | $539 | 2026-04-30 | Buy |
| Axon Medchem | Axon2959 | FM19G11 | 5mg | $104.5 | 2026-05-19 | Buy | |
| Axon Medchem | Axon2959 | FM19G11 | 25mg | $357.5 | 2026-05-19 | Buy | |
| aablocks | AA00CMPZ | FM19G11 | 329932-55-0 | 1mg | $55 | 2026-05-28 | Buy |
HIF-1alpha/2alpha Inhibitor Chemical Properties,Uses,Production
Uses
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
Definition
ChEBI: 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester is a member of benzamides.
Biochem/physiol Actions
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.
in vivo
FM19G11 ( intramedullary injection; 1-8 weeks) improves locomotion in severe spinal cord injury (SCI)[3].
FM19G11 ( intramedullary injection; 8 weeks) induces the expression of GAP43, an axon growth marker, and RIP, a marker for myelinated oligodendrocytes at the injury[3].
storage
Store at +4°C
HIF-1alpha/2alpha Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
HIF-1alpha/2alpha Inhibitor Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9710 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
