O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol
![O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol Structure](CAS/20180906/GIF/660843-21-0.gif)
- CAS No.
- 660843-21-0
- Chemical Name:
- O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol
- Synonyms
- t-Boc-Amido-PEG2-Mal;O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol;O-[2-(Boc-amino)ethyl]-O′-(2-maleimidoethyl)ethylene glycol;O-[2-(Boc-amino)ethyl]-O'-(2-maleimidoethyl)ethylene glycol >=96.0% (HPLC);tert-Butyl {2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl}carbamate;Carbamic acid, N-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
- CBNumber:
- CB32676952
- Molecular Formula:
- C15H24N2O6
- Molecular Weight:
- 328.36
- MDL Number:
- MFCD12912379
- MOL File:
- 660843-21-0.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | Soluble in DMSO, DCM |
| InChI | 1S/C15H24N2O6/c1-15(2,3)23-14(20)16-6-8-21-10-11-22-9-7-17-12(18)4-5-13(17)19/h4-5H,6-11H2,1-3H3,(H,16,20) |
| InChIKey | ANPNLGYUZZQPEV-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCOCCOCCN1C(=O)C=CC1=O |
| UNSPSC Code | 12352108 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 10 - Combustible liquids |
O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 16328 | O-[2-(Boc-amino)ethyl]-O′-(2-maleimidoethyl)ethylene glycol ≥96.0% (HPLC) | 660843-21-0 | 1g | $909 | 2026-04-30 | Buy |
| ChemScene | CS-0105533 | Mal-PEG2-NH-Boc ≥98% | 660843-21-0 | 1g | $1750 | 2026-06-04 | Buy |
| BroadPharm | bp-23291 | Mal-PEG2-NH-Boc 98% | 660843-21-0 | 100MG | $280 | 2026-05-24 | Buy |
| BroadPharm | bp-23291 | Mal-PEG2-NH-Boc 98% | 660843-21-0 | 250MG | $430 | 2026-05-24 | Buy |
| BroadPharm | bp-23291 | Mal-PEG2-NH-Boc 98% | 660843-21-0 | 500MG | $650 | 2026-05-24 | Buy |
O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol Chemical Properties, Uses, Production
Description
Mal-PEG2-NH-Boc is a PEG linker containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Uses
Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol Preparation Products And Raw materials
Raw materials
Preparation Products
O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Shanghai Union Medical Technology Co. Ltd. | 13120563767 | chemchen925@outlook.com | China | 624 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1978 | 58 |
| Changzhou Kechem Bio-Scientific Co., LTD. | 0519-68985668 13685222090 | sales@kechem.cn | China | 26012 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 770406999@qq.com | China | 9949 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| Shanghai Zhiyun Biotechnology Co., Ltd | 13119135307 | China | 2766 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38904 | 58 |
