ChemicalBook >> CAS DataBase List >>KU59403
KU59403
- CAS No.
- 845932-30-1
- Chemical Name:
- KU59403
- Synonyms
- KU59403;3-(4-methylpiperazin-1-yl)-N-[6-(6-morpholin-4-yl-4-oxopyran-2-yl)thianthren-2-yl]propanamide;3-(4-methylpiperazin-1-yl)-N-(6-(6-morpholino-4-oxo-4H-pyran-2-yl)thianthren-2-yl)propanamide;1-Piperazinepropanamide, 4-methyl-N-[6-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-2-thianthrenyl]-
- CBNumber:
- CB32710582
- Molecular Formula:
- C29H32N4O4S2
- Molecular Weight:
- 564.72
- MDL Number:
- MOL File:
- 845932-30-1.mol
Last updated:2025-09-29 22:33:22
KU59403 Chemical Properties,Uses,Production
Uses
KU 59403 is an Ataxia telangiectasia mutated inhibitor (ATM inhibitor) in models of human cancer.
in vivo
KU59403 with a single daily dose of 12.5 mg/kg causes a significant sensitization[1].
Increasing the dose of KU59403 to 25 mg/kg given twice daily results in the greatest chemo-sensitisation with a 3-fold increase in BMY-40481-induced tumour growth delay in both SW620 and HCT116-N7 xenografts, in the absence of a significantly increased toxicity[1].
| Animal Model: | CD-1 nude mice implanted with SW620 or HCT116-N7 human cancer cell lines at 1×107 cells per animal s.c. (n=5 per group)[1]. |
| Dosage: | 6, 12.5 and 25 mg/kg. |
| Administration: | I.P. twice daily (0 and 4 hours) and 12.5 mg/kg once daily. |
| Result: | Treatment with BMY-40481 alone causes a modest tumour growth delay of 4 days (time to RTV4=10.5 days). This delay is extended to 8.5 days when given with KU 59403 at 12.5 mg/kg i.p. twice daily for 5 days and 11.5 days (time to RTV4=18 days) when given with KU 59403 at 25 mg/kg i.p. twice daily for 5 days. |
KU59403 Preparation Products And Raw materials
Raw materials
Preparation Products
KU59403 Suppliers
Global( 19)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5167 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7892 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2680 | 58 |
KU59403
3-(4-methylpiperazin-1-yl)-N-[6-(6-morpholin-4-yl-4-oxopyran-2-yl)thianthren-2-yl]propanamide
1-Piperazinepropanamide, 4-methyl-N-[6-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-2-thianthrenyl]-
3-(4-methylpiperazin-1-yl)-N-(6-(6-morpholino-4-oxo-4H-pyran-2-yl)thianthren-2-yl)propanamide
845932-30-1
C29H32N4O4S2
