| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
KU59403 manufacturers
- KU 59403
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- $733.00
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2026-07-15
- CAS:845932-30-1
- Purity: 99.79%
- Supply Ability: 10g
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| | KU59403 Basic information |
| Product Name: | KU59403 | | Synonyms: | KU59403;3-(4-methylpiperazin-1-yl)-N-[6-(6-morpholin-4-yl-4-oxopyran-2-yl)thianthren-2-yl]propanamide;1-Piperazinepropanamide, 4-methyl-N-[6-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-2-thianthrenyl]-;3-(4-methylpiperazin-1-yl)-N-(6-(6-morpholino-4-oxo-4H-pyran-2-yl)thianthren-2-yl)propanamide | | CAS: | 845932-30-1 | | MF: | C29H32N4O4S2 | | MW: | 564.72 | | EINECS: | | | Product Categories: | | | Mol File: | 845932-30-1.mol |  |
| | KU59403 Chemical Properties |
| Boiling point | 814.3±65.0 °C(Predicted) | | density | 1.368±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 13.73±0.20(Predicted) | | form | Solid | | color | White to yellow |
| | KU59403 Usage And Synthesis |
| Uses | KU 59403 is an Ataxia telangiectasia mutated inhibitor (ATM inhibitor) in models of human cancer. | | in vivo | KU59403 with a single daily dose of 12.5 mg/kg causes a significant sensitization[1].
Increasing the dose of KU59403 to 25 mg/kg given twice daily results in the greatest chemo-sensitisation with a 3-fold increase in BMY-40481-induced tumour growth delay in both SW620 and HCT116-N7 xenografts, in the absence of a significantly increased toxicity[1].
| Animal Model: | CD-1 nude mice implanted with SW620 or HCT116-N7 human cancer cell lines at 1×107 cells per animal s.c. (n=5 per group)[1]. | | Dosage: | 6, 12.5 and 25 mg/kg. | | Administration: | I.P. twice daily (0 and 4 hours) and 12.5 mg/kg once daily. | | Result: | Treatment with BMY-40481 alone causes a modest tumour growth delay of 4 days (time to RTV4=10.5 days). This delay is extended to 8.5 days when given with KU 59403 at 12.5 mg/kg i.p. twice daily for 5 days and 11.5 days (time to RTV4=18 days) when given with KU 59403 at 25 mg/kg i.p. twice daily for 5 days. |
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| | KU59403 Preparation Products And Raw materials |
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