1-(4-Fluorophenyl)piperazin-2-one hydrochloride
- CAS No.
- 697305-48-9
- Chemical Name:
- 1-(4-Fluorophenyl)piperazin-2-one hydrochloride
- Synonyms
- 1-(4-Fluorophenyl)piperazin-2-one hydrochloride
- CBNumber:
- CB32735967
- Molecular Formula:
- C10H12ClFN2O
- Molecular Weight:
- 230.6664832
- MDL Number:
- MOL File:
- 697305-48-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
1-(4-Fluorophenyl)piperazin-2-one hydrochloride price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS43996 | 1-(4-Fluorophenyl)piperazin-2-one HCl 95% | 697305-48-9 | 1g | $255 | 2026-06-04 | Buy |
| Activate Scientific | AS43996 | 1-(4-Fluorophenyl)piperazin-2-one HCl 95% | 697305-48-9 | 5g | $782 | 2026-06-04 | Buy |
| Matrix Scientific | 297155 | 1-(4-Fluorophenyl)piperazin-2-one hydrochloride | 697305-48-9 | 250.00mg | $69 | 2026-05-19 | Buy |
| Matrix Scientific | 297155 | 1-(4-Fluorophenyl)piperazin-2-one hydrochloride | 697305-48-9 | 1.00g | $158 | 2026-05-19 | Buy |
| Matrix Scientific | 297155 | 1-(4-Fluorophenyl)piperazin-2-one hydrochloride | 697305-48-9 | 5.00g | $485 | 2026-05-19 | Buy |
1-(4-Fluorophenyl)piperazin-2-one hydrochloride Chemical Properties, Uses, Production
Uses
1-(4-Fluorophenyl)piperazin-2-one hydrochloride is used in the preperation of selective somatostatin receptor 2 agonists for treatment of type 2 diabetes
Synthesis
1284243-44-2
697305-48-9
Step 2: tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate (2 g, 6.80 mmol) was dissolved in dichloromethane (5 ml) and cooled to 0°C. A solution of hydrogen chloride in 1,4-dioxane (16.99 ml, 68.0 mmol) was slowly added to the reaction system under stirring. Subsequently, the reaction mixture was warmed up to 25 °C and the reaction was continued with stirring for 3 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was ground with ether (2 x 10 ml), decanted and dried to give 1-(4-fluorophenyl)piperazin-2-one hydrochloride (1.2 g, 5.20 mmol, 77% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 9.90 (broad single peak, 1H, D2O exchangeable), 7.38-7.34 (multiple peaks, 4H), 3.85-3.72 (multiple peaks, 4H), 3.55-3.50 (multiple peaks, 2H). Mass spectrometry analysis showed m/z 195 (M + 1).
References
[1] Patent: WO2011/41713, 2011, A2. Location in patent: Page/Page column 152
[2] Patent: US2015/152118, 2015, A1. Location in patent: Paragraph 0386 - 0389
1-(4-Fluorophenyl)piperazin-2-one hydrochloride Preparation Products And Raw materials
1-(4-Fluorophenyl)piperazin-2-one hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39645 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 43517 | 58 |
| Beijing Haite lesk Technology Co., Ltd | 15210893940; 15116916250 | chemistryliu@163.com | China | 7321 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54738 | 58 |
