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tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Structure
tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate structure
CAS No.
1284243-44-2
Chemical Name:
tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate
Synonyms
tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-(4-fluorophenyl)-3-oxo-, 1,1-dimethylethyl ester
CBNumber:
CB32735765
Molecular Formula:
C15H19FN2O3
Molecular Weight:
294.32
MDL Number:
MOL File:
1284243-44-2.mol
MSDS File:
SDS
Last updated:2026-05-28 01:10:28
Request For Quotation

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Properties

Boiling point 469.3±40.0 °C(Predicted)
Density 1.223±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 0.41±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Crysdot CD11300927 tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate 95+% 1284243-44-2 1g $537 2026-05-26 Buy
Chemenu CM169008 tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate 95% 1284243-44-2 1g $108 2026-05-26 Buy
aablocks AA000XZR tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate 95% 1284243-44-2 100mg $61 2026-05-25 Buy
aablocks AA000XZR tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate 95% 1284243-44-2 250mg $96 2026-05-25 Buy
aablocks AA000XZR tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate 95% 1284243-44-2 1g $233 2026-05-25 Buy
Product number Packaging Price Buy
CD11300927 1g $537 Buy
CM169008 1g $108 Buy
AA000XZR 100mg $61 Buy
AA000XZR 250mg $96 Buy
AA000XZR 1g $233 Buy

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Chemical Properties, Uses, Production

Synthesis

1-Boc-3-oxopiperazine

76003-29-7

4-Bromofluorobenzene

460-00-4

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate

1284243-44-2

3-Oxo-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (0.200 g, 0.999 mmol) and 1-bromo-4-fluorobenzene (0.091 mL, 0.832 mmol) were added with copper(I) iodide (0.008 g, 0.042 mmol), potassium carbonate (0.230 g, 1.665 mmol) and N,N'-dimethyl- 1,2-ethylenediamine (0.009 mL, 0.083 mmol) in toluene (5 mL). The mixture was heated to reflux overnight under nitrogen protection. Upon completion of the reaction, the reaction mixture was filtered through a pad of silica gel. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford 4-(4-fluorophenyl)-3-oxo-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (0.180 g, 73% yield) as a white solid.

References

[1] Patent: WO2011/41713, 2011, A2. Location in patent: Page/Page column 152
[2] Patent: WO2014/9872, 2014, A1. Location in patent: Page/Page column 63; 64
[3] Patent: US2015/152118, 2015, A1. Location in patent: Paragraph 0382 - 0385

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate synthesis

76003-29-7
460-00-4
1284243-44-2
Synthesis of tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate from 1-Boc-3-oxopiperazine and 4-Bromofluorobenzene

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

1-Boc-3-oxopiperazine 4-Bromofluorobenzene Di-tert-butyl dicarbonate N,N'-Dimethyl-1,2-ethanediamine Copper(l) iodide
Potassium carbonate Toluene

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Preparation Products

1-(4-Fluoro-phenyl)-piperazin-2-one

tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Suppliers

Global Suppliers ( 19)
Supplier Tel Email Country ProdList Advantage
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Hangzhou Milestone Pharmtech Co., Ltd. 0571-82896630 18969958410 sales_hz@milestonepharmtech.com China 4908 55
BePharm Ltd 400-685-9117 market@bepharm.com China 15081 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Suzhou Nuoouman Biological Technology Co., Ltd. 15026866316 180642609@qq.com China 4966 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd 2383948258 19172820304 2383948258@qq.com China 12983 58
Bide Pharmatech Ltd. 400-6005915 sales@picasso-e.com China 39645 58
Shanghai Jieshikai Biotechnology Co. , Ltd. 021-57520305 13795461237 zhuruyan@jskchem.com China 49221 58
Supplier Advantage
Cool Pharm, Ltd 58
Hangzhou Milestone Pharmtech Co., Ltd. 55
BePharm Ltd 60
Amadis Chemical Company Limited 58
Aikon International Limited 58
Suzhou Nuoouman Biological Technology Co., Ltd. 58
Energy Chemical 58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd 58
Bide Pharmatech Ltd. 58
Shanghai Jieshikai Biotechnology Co. , Ltd. 58

1284243-44-2 (tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate) Related Search:

1-(4-Fluorophenyl)piperazin-2-one hydrochloride 1-(4-Fluoro-phenyl)-piperazin-2-one 3-Oxo-4-phenyl-piperazine-1-carboxylic acid tert-butyl ester tert-butyl 4-(4-bromophenyl)-3-oxopiperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(4-aminophenyl)-3-oxo-, 1,1-dimethylethyl ester
tert-Butyl 4-(3-bromophenyl)-3-oxopiperazine-1-carboxylate

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tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(4-fluorophenyl)-3-oxo-, 1,1-dimethylethyl ester 1284243-44-2