BD 1047 dihydrobromide
- CAS No.
- 138356-21-5
- Chemical Name:
- BD 1047 dihydrobromide
- Synonyms
- 169592;BD1047.2HBr;BD 1047 HBr;BD-1047;BD 1047;BD1047.2HBr(1K/g);BD 1047 (hydrobromide);BD-1047 dihydrobromide, 10 mM in DMSO;BD-1047 dihydrobromide (BD1047 dihydrobromide);BD 1047 dihydrobromide, sigma1 receptor antagonist;N1-(3,4-DICHLOROPHENETHYL)-N1,N2,N2-TRIMETHYLETHANE-1,2-DIAMINE 2HBR
- CBNumber:
- CB32755978
- Molecular Formula:
- C13H22Br2Cl2N2
- Molecular Weight:
- 437.04118
- MDL Number:
- MFCD00792739
- MOL File:
- 138356-21-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Inert atmosphere,2-8°C |
|---|---|
| solubility | H2O: >5mg/mL |
| form | powder |
| color | white |
| Water Solubility | H2O: >5mg/mL |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H |
| InChIKey | WOALTFHGLDVJHK-UHFFFAOYSA-N |
| SMILES | Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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BD 1047 dihydrobromide price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B8562 | BD 1047 dihydrobromide ≥95% (HPLC) | 138356-21-5 | 5mg | $125 | 2026-04-30 | Buy |
| Sigma-Aldrich | B8562 | BD 1047 dihydrobromide ≥95% (HPLC) | 138356-21-5 | 25mg | $495 | 2026-04-30 | Buy |
| Cayman Chemical | 22928 | BD 1047 (hydrobromide) ≥98% | 138356-21-5 | 5mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 22928 | BD 1047 (hydrobromide) ≥98% | 138356-21-5 | 10mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 22928 | BD 1047 (hydrobromide) ≥98% | 138356-21-5 | 25mg | $259 | 2026-04-30 | Buy |
BD 1047 dihydrobromide Chemical Properties, Uses, Production
Description
BD 1047 is a selective antagonist of sigma-1 (σ1) receptors (Ki = 0.9 nM in a radioligand binding assay). It is selective for σ1 receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro. In vivo, pretreatment with BD 1047 protects against convulsions and lethality induced by cocaine (Item Nos. 16186 | ISO60176) and reduces cocaine-induced locomotor activity. It reduces dystonias induced by the σ receptor agonists haloperidol and di-o-tolylguanidine (DTG) in rats in a dose-dependent manner. In vivo administration of BD 1047 also attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain.
Uses
BD 1047 dihydrobromide is an σ1 receptor antagonist with higher affinity than BD 1063.
in vivo
BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice[1].
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine)[3].
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity[4].
| Animal Model: | Male Albino Swiss mice (50 days old, 25–28 g)[1] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased the APO-induced climbing at the dose of 10 mg/kg in mice. |
IC 50
Sigma 1 Receptor
storage
Desiccate at +4°C
References
[1] RAE R. MATSUMOTO . Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism[J]. European journal of pharmacology, 1995, 280 3: Pages 301-310. DOI:10.1016/0014-2999(95)00208-3
[2] KARI A. MCCRACKEN . Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity[J]. European journal of pharmacology, 1999, 370 3: Pages 225-232. DOI:10.1016/s0014-2999(99)00113-2
[3] TIEYING SONG. Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy.[J]. Biological Chemistry, 2017, 398 10: 1141-1149. DOI:10.1515/hsz-2017-0117
[4] YOUNG CHAN JEONG Young B K Ji Seon Son. The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats[J]. Brain Research Bulletin, 2015, 119: Pages 93-100. DOI:10.1016/j.brainresbull.2015.07.006
[5] DAE-HYUN ROH S Y Y. Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.[J]. Accounts of Chemical Research, 2014: 145-151. DOI:10.1248/bpb.b13-00690
[6] SHANSHAN ZHU. Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation.[J]. Mediators of Inflammation, 2015, 2015 1: 265056. DOI:10.1155/2015/265056
BD 1047 dihydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 645 | 55 |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
View Latest Price from BD 1047 dihydrobromide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | BD-1047 dihydrobromide
138356-21-5
|
$31.00-67.00 | 99.39% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-31 | BD 1047 dihydrobromide
138356-21-5
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- BD-1047 dihydrobromide
138356-21-5
- $31.00-67.00
- 99.39%
- TargetMol Chemicals Inc.
-
- BD 1047 dihydrobromide
138356-21-5
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
