diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
- CAS No.
- 120533-76-8
- Chemical Name:
- diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
- Synonyms
- BML-278;BML278|||BML 278;BML-278, SIRT activator;DI ETHYL 1 BENZYL 4 PHENYL 4H PYRIDINE 3-5 DICARBOXYLATE;Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate;diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-phenyl-1-(phenylmethyl)-, 3,5-diethyl ester
- CBNumber:
- CB33050728
- Molecular Formula:
- C24H25NO4
- Molecular Weight:
- 391.46
- MDL Number:
- MOL File:
- 120533-76-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| BML-278 ≥95% | 20209 | 1mg | $36 |
| BML-278 ≥95% | 20209 | 5mg | $86 |
| BML-278 ≥95% | 20209 | 10mg | $153 |
| BML-278 ≥95% | 20209 | 25mg | $336 |
| BML-278 ≥95% | 20209 | 1mg | $32 |
| Melting point | 139-141 °C(Solv: cyclohexane (110-82-7); benzene (71-43-2)) |
|---|---|
| Boiling point | 525.5±50.0 °C(Predicted) |
| Density | 1.183±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| form | solid |
| pka | 2.05±0.70(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20209 | BML-278 ≥95% | 120533-76-8 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 20209 | BML-278 ≥95% | 120533-76-8 | 5mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 20209 | BML-278 ≥95% | 120533-76-8 | 10mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 20209 | BML-278 ≥95% | 120533-76-8 | 25mg | $336 | 2026-04-30 | Buy |
| Cayman Chemical | 20209 | BML-278 ≥95% | 120533-76-8 | 1mg | $32 | 2024-03-01 | Buy |
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Chemical Properties,Uses,Production
Description
BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable.
Uses
Diethyl 1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a cell-permeable and potent SIRT activator that induces cell cycle arrest. SIRT modulators have therapeutic potential the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases.
Definition
ChEBI: 4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine.
Synthesis
100-52-7
100-46-9
623-47-2
120533-76-8
A mixture of benzaldehyde (0.05 mol), ethyl propargylate (0.10 mol), benzylamine (0.05 mol) and 5.0 mL of acetic acid was heated in a steam bath for 25 min [16,17]. After completion of the reaction, the crude product was purified by crystallization with a solvent mixture of methanol and water (4:1, v/v) followed by recrystallization with a solvent mixture of acetone and hexane (1:1, v/v) to give diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate.
References
[1] ANTONELLO MAI*. Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors[J]. Journal of Medicinal Chemistry, 2009, 52 17: 5496-5504. DOI:10.1021/jm9008289
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Preparation Products And Raw materials
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3709 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 19372819560 | Sales@ATKchemical.com | China | 9627 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22345 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15082 | 58 |
| 3A Chemicals | 400-668-9898 | service@3achem.com | China | 20557 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Career Henan Chemica Co | 58 |
| BOC Sciences | 58 |
| Labnetwork lnc. | 58 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 55 |
| BOC Sciences | 65 |
| Shanghai Chaolan Chemical Technology Center | 58 |
| Wuxi AppTec | 58 |
| Aikon International Limited | 58 |
| 3A Chemicals | 58 |
