(R)-(+)-Methyl p-tolyl sulfoxide
- CAS No.
- 1519-39-7
- Chemical Name:
- (R)-(+)-Methyl p-tolyl sulfoxide
- Synonyms
- (R)-(+)-METHYL P-TOLYL SULFOXIDE;(R)-methyl4-methylphenylsulfoxide;1-Methanesulfinyl-4-methyl-benzene;(R)-(+)-Methyl p-tolyl sulfoxide 99%;(R)-1-Methyl-4-(Methylsulfinyl)benzene;1-methyl-4-[(R)-methylsulfinyl]benzene;Benzene, 1-methyl-4-[(R)-methylsulfinyl]-;(R)-(+)-Methyl p-tolyl sulfoxide
- CBNumber:
- CB3276835
- Molecular Formula:
- C8H10OS
- Molecular Weight:
- 154.23
- MDL Number:
- MFCD00151502
- MOL File:
- 1519-39-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (R)-(+)-Methyl p-tolyl sulfoxide 99% | 343609 | 1g | $441 |
| (R)-(+)-Methyl p-tolyl sulfoxide 98% | OR913597 | 100mg | $62 |
| (R)-(+)-Methyl p-tolyl sulfoxide 98% | OR913597 | 250mg | $74 |
| (R)-(+)-Methyl p-tolyl sulfoxide 98% | OR913597 | 1g | $160 |
| (R)-(+)-Methyl p-tolyl sulfoxide 98% | OR913597 | 5g | $564 |
| Melting point | 73-75 °C(lit.) |
|---|---|
| Boiling point | 247.62°C (rough estimate) |
| alpha | 145 º (c=2, acetone) |
| Density | 1.1125 (rough estimate) |
| refractive index | 1.5780 (estimate) |
| storage temp. | Storage temp. 2-8°C |
| form | Solid |
| Appearance | White to off-white Solid |
| optical activity | [α]20/D +145°, c = 2 in acetone |
| BRN | 2040677 |
| InChI | 1S/C8H10OS/c1-7-3-5-8(6-4-7)10(2)9/h3-6H,1-2H3/t10-/m1/s1 |
| InChIKey | FEVALTJSQBFLEU-SNVBAGLBSA-N |
| SMILES | Cc1ccc(cc1)S(C)=O |
| UNSPSC Code | 12191600 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H302+H312+H332-H315 |
| Precautionary statements | P261-P271-P280 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 3-10 |
| HS Code | 2930909899 |
| Storage Class | 11 - Combustible Solids |
(R)-(+)-Methyl p-tolyl sulfoxide price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 343609 | (R)-(+)-Methyl p-tolyl sulfoxide 99% | 1519-39-7 | 1g | $441 | 2026-04-30 | Buy |
| Apolloscientific | OR913597 | (R)-(+)-Methyl p-tolyl sulfoxide 98% | 1519-39-7 | 100mg | $62 | 2026-06-04 | Buy |
| Apolloscientific | OR913597 | (R)-(+)-Methyl p-tolyl sulfoxide 98% | 1519-39-7 | 250mg | $74 | 2026-06-04 | Buy |
| Apolloscientific | OR913597 | (R)-(+)-Methyl p-tolyl sulfoxide 98% | 1519-39-7 | 1g | $160 | 2026-06-04 | Buy |
| Apolloscientific | OR913597 | (R)-(+)-Methyl p-tolyl sulfoxide 98% | 1519-39-7 | 5g | $564 | 2026-06-04 | Buy |
(R)-(+)-Methyl p-tolyl sulfoxide Chemical Properties,Uses,Production
Uses
Used in asymmetric synthesis; adds diastereoselectively to carbony compounds, esters, imines, nitrones, and nitrile oxides.
General Description
(R)-(+)-Methyl p-tolyl sulfoxide may be used to prepare (R)-(+)-methyl 3,5-dimethoxy-6-[8-oxo-9-(p-tolylsulfinyl) nonyl] benzoate, an intermediate for (R)-lasiodiplodin synthesis. Its anions undergo addition reaction with nitrones to form optically active a-substituted N-hydroxylamines. (R)-(+)-Methyl p-tolyl sulfoxide also reacts with O-mesitylsulfonylhydroxylamine (MSH) to form (-)-(R)-S-methyl-S-p-tolylsulfoximine.
Synthesis
(R)-(+)-Methyl p-tolyl sulfoxide is prepared by the nucleophilic displacement of (-)- (1R,2S,5R)-Menthyl (S)-p-Toluenesulfinate with methyl Grignard with complete inversion of configuration at sulfur (eq 1).
Synthesis
Highly sensitive to air and moisture. Its generation and handling must be carried out under an inert atmosphere of nitrogen or argon. Normally, preparation is carried out immediately prior to use.
(R)-(+)-Methyl p-tolyl sulfoxide Preparation Products And Raw materials
(R)-(+)-Methyl p-tolyl sulfoxide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44849 | 61 |
| AllyChem Co., Ltd. | 0411-62313318 13889470786 | info@allychem.com | China | 1021 | 65 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7554 | 55 |
| AgileBioChem Co., Ltd. | 0555-18055517827 18055517827 | sales@agilebiochem.com | China | 996 | 50 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
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