1-Boc-4-(4-fluoro-phenylamino)-piperidine
- CAS No.
- 288573-56-8
- Chemical Name:
- 1-Boc-4-(4-fluoro-phenylamino)-piperidine
- Synonyms
- tert-butyl 4-(4-fluoroanilino)piperidine-1-carboxylate;KS0037;Pharmaceutical Powder;tert-Butyl 4-(4-fluoroanilino)-1-;1-Piperidinecarboxylicacid CAS 288573-56-8;High purity 4-[(4-fluorophenyl)amino]- CAS 288573-56-8;KS-0037 powder;*Fentanyl Impurity 257;para-fluoro 4-Anilino-1-Boc-piperidine;1,1-dimethylethyl ester CAS 288573-56-8
- CBNumber:
- CB3280285
- Molecular Formula:
- C16H23FN2O2
- Molecular Weight:
- 294.36
- MDL Number:
- MFCD07785990
- MOL File:
- 288573-56-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 400.4±40.0 °C(Predicted) |
|---|---|
| Density | 1.159±0.06 g/cm3(Predicted) |
| solubility |
DMF: 30 mg/ml DMSO: 30 mg/ml Ethanol: 30 mg/ml |
| pka | 5.09±0.20(Predicted) |
| InChI | InChI=1S/C16H23FN2O2/c1-16(2,3)21-15(20)19-10-8-14(9-11-19)18-13-6-4-12(17)5-7-13/h4-7,14,18H,8-11H2,1-3H3 |
| InChIKey | TUYSUNKDSSHKHM-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(NC2=CC=C(F)C=C2)CC1 |
| FDA UNII | 5PT28N6ELP |
1-Boc-4-(4-fluoro-phenylamino)-piperidine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 39539 | para-fluoro 4-Anilino-1-Boc-piperidine ≥98% | 288573-56-8 | 1mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 39539 | para-fluoro 4-Anilino-1-Boc-piperidine ≥98% | 288573-56-8 | 5mg | $290 | 2026-04-30 | Buy |
| American Custom Chemicals Corporation | HCH0049921 | 1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE 95.00% | 288573-56-8 | 1MG | $586.97 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0049921 | 1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE 95.00% | 288573-56-8 | 10MG | $618.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0049921 | 1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE 95.00% | 288573-56-8 | 5MG | $623.82 | 2021-12-16 | Buy |
1-Boc-4-(4-fluoro-phenylamino)-piperidine Chemical Properties, Uses, Production
Chemical Properties
1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine (Tert-Butyl 4- (4-fluoroanilino) Piperidine-1-Carboxylate) is a white solid.
Uses
1-Boc-4-(4-fluoro-phenylamino)-piperidine (Tert-Butyl 4- (4-fluoroanilino) Piperidine-1-Carboxylate) is a heterocyclic derivative and can be used as a pharmaceutical intermediate.
Preparation
Sodium cyanoborohydride (661 mg, 10.0 mmol) was added to a methylene chloride solution (30 ml) of t-butyl 4-oxopiperidine-1-carboxylate (2.66 g, 13.1 mmol), 4-fluoroaniline (1.46 g, 13.1 mmol) and acetic acid (0.750 ml, 13.1 mmol), at 0°C, and stirring was carried out at room temperature for 15 hours. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction solution, followed by extraction with ethyl acetate, and the extract was washed sequentially with water and saline, and dried over anhydrous sodium sulfate. The organic layer was concentrated and the resulting residue was washed with diisopropyl ether, followed by drying to afford 1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine. Yield 80%.
