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Bisoctrizole

Bisoctrizole Structure
Bisoctrizole structure
CAS No.
103597-45-1
Chemical Name:
Bisoctrizole
Synonyms
UV-360;MBBT;METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL;Bisoctrizole;METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENO;2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol];2,2'-METHYLENEBIS[6-(2H-BENZOTRIAZOL-2-YL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL];2,2-methylenebis(6-(2H-benzotriazol-2-yl) -4-(1,;Methylene bisbenzotriazoryl tetramethylbutyl phenol;2,2′-Methylenbis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
CBNumber:
CB3283802
Molecular Formula:
C41H50N6O2
Molecular Weight:
658.87
MDL Number:
MFCD01103222
MOL File:
103597-45-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:15:07
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Bisoctrizole Properties

Melting point 197-199 °C(lit.)
Boiling point 771.6±70.0 °C(Predicted)
Density d20 1.2
vapor pressure 0Pa at 25℃
Flash point >200°C
storage temp. Inert atmosphere,Room Temperature
solubility almost transparency in THF
pka 7.62±0.50(Predicted)
form Solid
color White to Orange to Green
Water Solubility Insoluble < 5 ng/L at 25 °C
Merck 14,1294
BRN 11326835
Stability Light Sensitive
Major Application cleaning products
cosmetics
environmental
food and beverages
personal care
Cosmetics Ingredients Functions UV FILTER
LIGHT STABILIZER
InChIKey ZRFPPIQVEQSFRV-UHFFFAOYSA-N
SMILES CC(C)(C)CC(C)(C)c1cc(Cc2cc(cc(c2O)-n3nc4ccccc4n3)C(C)(C)CC(C)(C)C)c(O)c(c1)-n5nc6ccccc6n5
LogP 4.2 at 20℃
CAS DataBase Reference 103597-45-1(CAS DataBase Reference)
FDA UNII 8NT850T0YS
EPA Substance Registry System Phenol, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)- (103597-45-1)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Risk Statements  36/37/38-53
Safety Statements  26-36/37/39-61
WGK Germany  1
TSCA  TSCA listed
HS Code  29339900
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
0 0

Bisoctrizole price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 30184 Bisoctrizole analytical standard 103597-45-1 100mg $131 2026-04-30 Buy
Sigma-Aldrich 1075677 Bisoctrizole United States Pharmacopeia (USP) Reference Standard 103597-45-1 200mg $443 2026-04-30 Buy
TCI Chemical M1259 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] >98.0%(HPLC) 103597-45-1 25g $52 2026-04-30 Buy
TCI Chemical M1259 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] >98.0%(HPLC) 103597-45-1 500g $483 2026-04-30 Buy
TRC TRC-B508870-50G Bisoctrizole 103597-45-1 50g $347 2026-06-03 Buy
Product number Packaging Price Buy
30184 100mg $131 Buy
1075677 200mg $443 Buy
M1259 25g $52 Buy
M1259 500g $483 Buy
TRC-B508870-50G 50g $347 Buy

Bisoctrizole Chemical Properties, Uses, Production

Chemical Properties

White powder

Chemical Properties

Wavelengths covered: about 280-400 nm, which covers both UVB and UVA ranges; peak protection at 303 nm and 358 nm.

Uses

Bisoctrizole is a light stabilizer in polymers and resins. It is majorly used as a UV filter in sunscreens and in photo-luminescent dyes for organic electronic based applications.

Application

Bisoctrizole is a non-FDA-approved combination sunscreen, but is approved in the EU and other parts of the world as a UV filter in sunscreens, day care products, and skin-whitening products at concentrations up to 10%.

Definition

ChEBI: Bisoctrizole is a diarylmethane. It is a broad-spectrum organic UV filter that is marketed as Tinosorb M. It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B rays.

brand name

Tinosorb M (Ciba Specialty Chemicals).

General Description

Bisoctrizole is a benzotriazole based additive that is used as an ultraviolet absorber (UVA). It reduces degradation of the polymeric material by absorbing the UV radiation and converting it to thermal heat. Bisoctrizole is often added to sunscreen formulations that It may protect skin against blue light and other environmental assaults.

Side effects

At present, Bisoctrizole has good safety, photostability and effectiveness, and rarely causes skin irritation. Severe allergic reactions are rare, which may be related to the fact that it is not significantly absorbed by the skin. If you experience symptoms such as difficulty breathing or swallowing, chest tightness, rash, swelling and urticaria, you need to seek medical attention immediately. Due to the lack of clinical studies on Bisoctrizole, long-term use and adverse reactions remain to be investigated.

Safety

Bisoctrizole appears to be relatively non-toxic and rarely causes skin irritation. As with many synthetic chemicals, whether bisoctrizole may produce low-level skin damage or systemic effects with long-term use is unclear. Considering that bisoctrizole is stable, poorly soluble, and minimally absorbed by the skin, the risks appear to be low. Still, more research on bisoctrizole safety is needed.

Synthesis

N,N,N',N'-TETRA(N-PROPYL)METHYLENEDIAMINE

10333-53-6

UV-329

3147-75-9

Bisoctrizole

103597-45-1

1. Synthesis procedure: In a 500 mL three-necked flask equipped with a stirrer, thermometer and distillation receiver, 323 g of ultraviolet absorber UV-329, 4 g of powdered sodium hydroxide, 128 g of bis(di-n-propylamino)methane and 15 g of tetrabutylammonium bromide were added sequentially. The reaction mixture was heated to 130°C under reduced pressure at 100 mmHg with continuous stirring. During the reaction, the resulting di-n-propylamine was collected by distillation. After the reaction was carried out for 2 h, the heating was stopped and the vacuum was released. A total of 108 g of di-n-propylamine was recovered (theoretical yield: 122 g) with 88.5% recovery and 98.6% purity. 2. Purification step: When the temperature of the reaction system was lowered to 110°C, 500 g of toluene was slowly added to dissolve all the solids. After complete dissolution, the temperature of the system was lowered to 90°C. About 40 g of 18% aqueous hydrochloric acid was added dropwise slowly and stirred until the reaction system was neutral. The reaction mixture was transferred to a beaker and the crystals were cooled and crystallized in an ice water bath for 4-5 hours. The crystals were collected by filtration and washed twice with 150 mL of deionized water and twice with 250 mL of methanol sequentially. The resulting wet product was dried at 100~110°C to obtain 266 g of ultraviolet absorber UV-360 (theoretical yield: 329 g), the product melting point was 197~198°C, the yield was 80.9% and the purity was 99.6%.

References

[1] Patent: CN106478530, 2017, A. Location in patent: Paragraph 0036-0039
[2] Patent: CN106632111, 2017, A. Location in patent: Paragraph 0033; 0034; 0035; 0036; 0037-0049; 0052; 0053

Bisoctrizole synthesis

50-00-0
3147-75-9
103597-45-1
Synthesis of Bisoctrizole from Formaldehyde and UV-329

Bisoctrizole Preparation Products And Raw materials

Raw materials

N,N,N',N'-Tetra(N-propyl)methylenediamine UV-329 Formaldehyde Tetrabutylammomium bromide Sodium hydroxide

Preparation Products

Bisoctrizole Suppliers

Global Suppliers ( 437)
Supplier Tel Email Country ProdList Advantage
FUJIAN DISHENG TECHNOLOGY CO.,LTD. 0571-88226505 17757185101 ah@dishengchem.com China 41 58
Jiangxi Lotchem Co., Ltd. 0791-0791-85061535 15270827708 lancetu@jxlotchem.com China 300 58
Qingdao Jiebaiao Auxiliaries Co. LTD 053268077006 17685522406 tangyu@jadenmtc.com China 327 58
Hangzhou Jingyou Chemical Co., Ltd. 87211835 13957193240 sales@jingyouchem.com China 211 58
AILY INTL CHEMICAL CORP LTD 025-83208295 18913388297 ben@ailychem.com China 132 50
Shanxi Xinchao New Materials Co., Ltd. 18305035622 sales@kefengchem.net China 12 58
Weihai Jinwei ChemIndustry.,Ltd 631-5584168 13370536333 wangruijwchem@163.com China 7 58
Hubei Science Chemical Co., Ltd 15994282563 15994282563 3775234439@qq.com China 2378 58
Tianjin Zhongxin Chemtech Co., Ltd. 022-66880623 sales@tjzxchem.com China 612 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
FUJIAN DISHENG TECHNOLOGY CO.,LTD. 58
Jiangxi Lotchem Co., Ltd. 58
Qingdao Jiebaiao Auxiliaries Co. LTD 58
Hangzhou Jingyou Chemical Co., Ltd. 58
AILY INTL CHEMICAL CORP LTD 50
Shanxi Xinchao New Materials Co., Ltd. 58
Weihai Jinwei ChemIndustry.,Ltd 58
Hubei Science Chemical Co., Ltd 58
Tianjin Zhongxin Chemtech Co., Ltd. 60
J & K SCIENTIFIC LTD. 76

Related articles

View Latest Price from Bisoctrizole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ultraviolet Absorbent UV-360 pictures 2026-09-18 Ultraviolet Absorbent UV-360
103597-45-1
 1KG 99%min 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
Ultraviolet Absorbent UV-360 pictures 2026-09-18 Ultraviolet Absorbent UV-360
103597-45-1
 1KG ≥99% 300mt/year Jinan Finer Chemical Co., Ltd
Bisoctrizole(UV-360) pictures 2026-07-22 Bisoctrizole(UV-360)
103597-45-1
 1kg 99% 20MT Watson Biotechnology Co.,Ltd

Bisoctrizole Spectrum

Bisoctrizole(103597-45-1)1HNMRBisoctrizole(103597-45-1)IRBisoctrizole(103597-45-1)Raman

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2,2-methylenebis(6-(2H-benzotriazol-2-yl) -4-(1, Methylenebisbenzotriazolyltertoctylphenol] 2,2'-Methylenebis[2-hydroxy-5-(1,1,3,3-tetramethylbutyl)-1,3-phenylene]bis(2H-benzotriazole) BIS[3-(BENZOTRIAZOL-2-YL)-2-HYDROXY-5-TERT-OCTYLPHENYL]METHANE 2,2'-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] Solution, 100ppm 2,2'-METHYLENEBIS(6-(2H-BENZOTRIAZOL-2-Y L) -4-(1,1,3,3TETRAMETHYLBUTYL)PHENOL)99 ULTRAVIOLET ABSORBER UV-360 (TINUVIN360) UV ABSORBER-360 (UV360) Phenol, 2,2-methylenebis6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)- TINOSORB(R)M 2,2′-Methylenbis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) Bis-[2-hydroxy-5-tert-octyl-3-(benzotriazol-2-yl)-phenyl]-methane 2,2''-METHYLENEBIS[6-(BENZOTRIAZOL-2-YL)-4-TERT-OCTYLPHENOL] 98+% Ultraviolet Absorbent UV-360 bis[2-hydroxy-5-t-octyl-3-(benzotriazolyl)phenyl]methane 2,2'-Methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-(2H-benzotriazol-2-yl)phenol] 2,2'-Methylenebis[4-tert-octyl-6-(2H-benzotriazole-2-yl)phenol] Methylene bisbenzotriazoryl tetramethylbutyl phenol UV Absorber 360 Bisoctrizole (200 mg) 2,2'-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetamethylbuty)phenol] 2,2-Methylenebis[3-(2H-benzotriazol-2-yl)-5-(1,1,3,3-tetramethylbutyl)phenol],99% 2,2-Methylenebis[6-(Benzotriazol-2-yl)-4-Tert-OCLylphenol] UV-360 Ultraviolet Absorber Methylene bis[(3-(2-benzotrizolyl)-2-hydroxy-5-tert-octylphenyl] 6,6'-Methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2-Methylheptan-2-yl)phenol) Samsorb UV-360 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] HRsorb-360 3-(2-benzotriazolyl)-2-[[2-(2-benzotriazolyl)-6-hydroxy-4-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-5-(2,4,4-trimethylpentan-2-yl)phenol LOTSORB UV 360 UV360/MBBT Absorber UV-360 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol]> Milestab-360 UV-360 Solution in THF, 1000μg/mL Ultraviolet Absorbent UV-360 ISO 9001：2015 REACH UV ABSORBER TRUELICHT UV 360 TINUVIN 360 (UV-360) Light Stabilizer UV-Absorber RIASORB UV-360/360FF Bisoctrizole (1075677) Absorbent UV-360 Ultraviolet Absorbent UV-360 METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL (NANO) Bisoctrizole Sinosorb? 360 Methylenebis(2-hydroxy-3-(benzotriazol-2-yl)-5-tertoctylphenyl) Dsunpro Mbbt 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol, ≥ 98.0% 6,6'-Methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol) Bisoctrizole(UV-360) 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol] in isooctane Bisoctrizole in THF C10653900 Bisoctrizole 2,2'-Methylenebis(4-Tert-Octyl-6-Benzotriazolephenol) 2,2′-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] CHLUMIUV 360 Bisoctrizole (Standard) 2,2'-Methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol]