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Lactofen

Lactofen structure

CAS No.: 77501-63-4

Chemical Name:: Lactofen

Synonyms: COBRA;ppg844;Phoenix;LACTOFEN;COBRA(R);cobra (tm);Lactofen (>cobraherbicide;Lactofen (>85%);-2-oxoethylester

CBNumber:: CB3288630

Molecular Formula:: C19H15ClF3NO7

Molecular Weight:: 461.77

MDL Number:: MFCD01632761

MOL File:: 77501-63-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-31 15:25:14

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Lactofen Properties

Melting point	approximate 48℃(dec.)
Boiling point	494.0±45.0 °C(Predicted)
Density	1.4660 (estimate)
storage temp.	0-6°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Water Solubility	110μg/L at 20℃
Henry's Law Constant	2.1×10¹ mol/(m³Pa) at 25℃, Duchowicz et al. (2020)
Major Application	agriculture environmental
InChI	1S/C19H15ClF3NO7/c1-3-29-17(25)10(2)30-18(26)13-9-12(5-6-15(13)24(27)28)31-16-7-4-11(8-14(16)20)19(21,22)23/h4-10H,3H2,1-2H3
InChIKey	CONWAEURSVPLRM-UHFFFAOYSA-N
SMILES	CCOC(=O)C(C)OC(=O)c1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1[N+]([O-])=O
LogP	4.6 at 40℃
CAS DataBase Reference	77501-63-4(CAS DataBase Reference)
FDA UNII	L44N8UV47O
Proposition 65 List	Lactofen
Pesticides Freedom of Information Act (FOIA)	Lactofen
EPA Substance Registry System	Lactofen (77501-63-4)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H312-H411
Precautionary statements	P273-P280-P302+P352+P312
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn,N
Risk Statements	21-51/53
Safety Statements	36/37-61
RIDADR	UN3077 9/PG 3
WGK Germany	2
RTECS	DG5643120
HS Code	29189900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Aquatic Chronic 2
Hazardous Substances Data	77501-63-4(Hazardous Substances Data)
REACH Registrations	Inactive

Lactofen price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	32972	Lactofen PESTANAL	77501-63-4	100mg	$154	2026-04-30	Buy
TRC	TRC-L113750-500MG	Lactofen (>85%)	77501-63-4	500mg	$90	2026-06-03	Buy
TRC	TRC-L113750-1G	Lactofen (>85%)	77501-63-4	1g	$171	2026-06-03	Buy
TRC	TRC-L113750-10G	Lactofen (>85%)	77501-63-4	10g	$967	2026-06-03	Buy
Usbiological	015430	Lactofen ≥85%	77501-63-4	1g	$446	2026-06-03	Buy

Product number	Packaging	Price	Buy
32972	100mg	$154	Buy
TRC-L113750-500MG	500mg	$90	Buy
TRC-L113750-1G	1g	$171	Buy
TRC-L113750-10G	10g	$967	Buy
015430	1g	$446	Buy

Lactofen Chemical Properties, Uses, Production

Uses

Lactofen is a complex ester derivative of Acifluoren, a diphenyl ether herbicide. Lactofen can be used in postemergence applications and is commonly used as foliar spray. Lactofen is used in agriculture to control broadleaved weeds in soybean, cereals, potatoes and peanuts.

Production Methods

Lactofen is commercially produced via a 4–5 step convergent synthesis that begins with nitration of 4-chlorobenzotrifluoride to 4-chloro-3-nitrobenzotrifluoride using an acid mixture, followed by nucleophilic aromatic substitution with ethyl 2-hydroxypropionate under basic conditions to form the diphenyl ether linkage. Reduction of the nitro group to amine is achieved via catalytic hydrogenation. The key acylation uses 2-chloro-4-(trifluoromethyl)phenoxyacetyl chloride in the presence of triethylamine in dichloromethane.

General Description

Dark brown to tan solid. Insoluble in water. Used as an herbicide.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Lactofen is a diphenyl ether derivative.

Mechanism of action

Protoporphyrinogen oxidase inhibition, absorbed by foliage with limited translocation

Pesticide Type

Herbicide

Lactofen Preparation Products And Raw materials

Raw materials

Acifluorfen 2-nitro-5-fluorobenzoic acid Ethyl propionate 3,4-Dichlorobenzotrifluoride Potassium carbonate

3-Hydroxybenzoic acid 3-Chloro-4-hydroxybenzotrifluoride Trifluoromethane Dimethyl sulfoxide Petri dish

Methyl benzoate Potassium benzoate

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Preparation Products

Lactofen Suppliers

Global Suppliers ( 143)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
China Langchem Inc.	0086-21-58956006		China	7798	57
Chengdu Ai Keda Chemical Technology Co., Ltd.	4008-755-333 18080918076	800078821@qq.com	China	9706	55
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
Nanjing Sunlida Biological Technology Co., Ltd.	025-57798810 18652991625	sales@sunlidabio.com	China	3223	55
TianJin Alta Scientific Co., Ltd.	022-65378550-8551	contact@altascientific.com	China	2772	58
Hubei Jusheng Technology Co.,Ltd	027-59599241 18871490274	1400878000@qq.com	China	9506	58
AN PharmaTech Co Ltd	86(21)68097365	sales@anpharma.net	China	4875	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
Sichuan Kulinan Technology Co., Ltd	57
China Langchem Inc.	57
Chengdu Ai Keda Chemical Technology Co., Ltd.	55
Shanghai T&W Pharmaceutical Co., Ltd.	58
Nanjing Sunlida Biological Technology Co., Ltd.	55
TianJin Alta Scientific Co., Ltd.	58
Hubei Jusheng Technology Co.,Ltd	58
AN PharmaTech Co Ltd	55

77501-63-4 (Lactofen) Related Search:

Dimethyldimethoxysilane Methanol Diclofop Methylparaben Quizalofop-ethyl

Fenoxaprop-P Methyltriethoxysilane Diethoxydimethylsilane 2-(4-((3-Chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)-propanoic acid methyl ester Methyl salicylate

Methyl acrylate Methyltrimethoxysilane Fluazifop-butyl Tribenuron methyl Ethyl lactate

Fenoxaprop-ethyl phenoxybenzamine Methyl

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5-(2-CHLORO-4-TRIFLUORMETHYLPHENOXY)-2-NITROBENZYL LACTATE 1’-(carboethoxy)ethyl5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate -2-oxoethylester 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitro-benzoicaci2-ethoxy-1-meth 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitro-benzoicaci2-ethoxy-1-methyl-2-oxoethylester 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoicacid2-ethoxy-1-methyl Benzoicacid,5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitro-,2-ethoxy-1-methyl-2-oxoethylester cobraherbicide 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitro-benzoic acid (2-ethoxy-2-keto-1-methyl-ethyl) ester 2-Ethoxy-1-methyl-2-oxoethyl 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoate Ethyl O-[5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-nitrobenzoyl]-DL-lactate Lactofen (>85%) Phoenix 2-ethoxy-1-methyl-2-oxoethyl 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate LACTOFEN COBRA COBRA(R) ETHYL O-[5-(2-CHLORO-A,A,A-TRIFLUORO-P-TOLYLOXY)-2-NITROBENZENZOYL]-DL-LACTATE ETHYL-O-[5-(2-CHLORO-A, A, A-TRIFLUORO-P-TOLYLOXY)-2-NITROBENZOYL]-DL-LACTATE ppg844 yl-2-oxoethylester (±)-2-ethoxy-1-ethyl-2-oxoethyl-5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate ethyl O-(5-(2-chloro-α,α,α-trifluoro-P-tolyloxy)-2-nitrobenzoyl)-DL-lactate 1-(Ethoxycarbonyl)ethyl 5-(2-chloro-alpha,alpha,alpha-trifluoro-p-tolyloxy)-2-nitrobenzoate 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoic acid 2-ethoxy-1-methyl-2-oxoethyl ester Benzoic acid, 5-(2-chloro-4-(trifluoromethyl)phenoxy (1-ethoxy-1-oxo-propan-2-yl) 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitro-benzoate (1-ethoxy-1-oxopropan-2-yl) 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate LACTOFEN:ETHYL-O-[5-(2-CHLORO- ALPHA , ALPHA , ALPHA -TRIFLUORO-P-TOLYLOXY)-2-NITROBENZOY] -DL-LACTATE LACTOFEN:ETHYL-O-[5-(2-CHLORO- A , A , A -TRIFLUORO-P-TOLYLOXY)-2-NITROBENZOY] -DL-LACTATE Ethyl O-[5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-nitrobenzoyl]-DL-lactate, 2-Ethoxy-1-methyl-2-oxoethyl 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrobenzoate LACTOFEN:ETHYL-O-[5-(2-CHLORO- α , α , α -TRIFLUORO-P-TOLYLOXY)-2-NITROBENZOY] -DL-LACTATE cobra (tm) lactofen (ansi,wssa) Lactofen@100 μg/mL in Acetonitrile Lactofen Standard Lactofen@1000 μg/mL in Acetonitrile Lactofen (> 80% lactifluofop-ethyl technical C14590000 Lactofen Lactofen in Acetonitrile 77501-63-4 3513-60-4 C19H15ClF3NO7 C20H17ClF3NO7 Agro-Products Aromatics Intermediates & Fine Chemicals Pharmaceuticals