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ChemicalBook >> CAS DataBase List >>3-Chloro-4-hydroxybenzotrifluoride

3-Chloro-4-hydroxybenzotrifluoride

3-Chloro-4-hydroxybenzotrifluoride Structure
3-Chloro-4-hydroxybenzotrifluoride structure
CAS No.
35852-58-5
Chemical Name:
3-Chloro-4-hydroxybenzotrifluoride
Synonyms
2-CHLORO-4-(TRIFLUOROMETHYL)PHENOL;3-Chloro-4-hydroxybe;2-chloro-4-trifluoromethylphenl;2-Chloro-4-(trifuloromethyl)phenol;3-CHLORO-4-HYDROXYBENZOTRIFLUORIDE;3-chloro-4-hydroxytrifluoromethylene;Phenol, 2-chloro-4-(trifluoromethyl)-;3-Chloro-4-hydroxybenzotrifluoride98%;3-Chloro-4-hydroxybenzotrifluoride 98%;2-chloro-4-(trifluoromethyl)phenol - [C86577]
CBNumber:
CB6678371
Molecular Formula:
C7H4ClF3O
Molecular Weight:
196.55
MDL Number:
MFCD00042217
MOL File:
35852-58-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:48:18
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3-Chloro-4-hydroxybenzotrifluoride Properties

Boiling point 66°C/13mmHg(lit.)
Density 1.474±0.06 g/cm3(Predicted)
refractive index 1.4740 to 1.4780
Flash point 68°C(lit.)
storage temp. 2-8°C
form clear liquid
pka 7.09±0.18(Predicted)
color Colorless to Light yellow
InChI InChI=1S/C7H4ClF3O/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3,12H
InChIKey YNWKEXMSQQUMEL-UHFFFAOYSA-N
SMILES C1(O)=CC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference 35852-58-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P271-P280
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
HazardClass  IRRITANT
HS Code  2933499090
NFPA 704
2
3 0

3-Chloro-4-hydroxybenzotrifluoride price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS003105 2-Chloro-4-(trifluoromethyl)phenol AldrichCPR 35852-58-5 250mg $68.1 2023-01-07 Buy
TCI Chemical C3355 2-Chloro-4-(trifluoromethyl)phenol >98.0%(GC) 35852-58-5 5g $135 2026-04-30 Buy
TCI Chemical C3355 2-Chloro-4-(trifluoromethyl)phenol >98.0%(GC) 35852-58-5 25g $543 2026-04-30 Buy
Biosynth FC64432 2-Chloro-4-(trifluoromethyl)phenol 35852-58-5 25g $150 2026-06-04 Buy
Biosynth FC64432 2-Chloro-4-(trifluoromethyl)phenol 35852-58-5 50g $172 2026-06-04 Buy
Product number Packaging Price Buy
CDS003105 250mg $68.1 Buy
C3355 5g $135 Buy
C3355 25g $543 Buy
FC64432 25g $150 Buy
FC64432 50g $172 Buy

3-Chloro-4-hydroxybenzotrifluoride Chemical Properties, Uses, Production

Synthesis

4-Trifluoromethylphenol

402-45-9

3-Chloro-4-hydroxybenzotrifluoride

35852-58-5

1. Oxidation: 4-(Trifluoromethyl)benzaldehyde (1.54 g, 6.75 mmol, 1.0 eq.) and dichloromethane (20 mL) were added to a round-bottomed flask and m-chloroperoxybenzoic acid (mCPBA, 1.52 g, 6.78 mmol, 1.0 eq.) was added slowly at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium bisulfite solution (15 mL). The mixture was transferred to a partition funnel and extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4-(trifluoromethyl)phenol in 71% yield. 2. Chlorination reaction: N-chlorosuccinimide (NCS, 25.0 mmol, 3.4 g) and dichloromethane (20.0 mL) were added to another round-bottomed flask and cooled to -78 °C. The reaction was carried out by adding zirconium tetrachloride (ZrCl2) to the mixture. Zirconium tetrachloride (ZrCl4, 0.5 mmol, 300 mg) was added, followed by 4-(trifluoromethyl)phenol (25.0 mmol). The reaction mixture was warmed to room temperature and stirred for 6 hours. After completion of the reaction, it was extracted with saturated aqueous sodium bicarbonate. The organic phases were combined and the solvent was removed under reduced pressure to afford 2-chloro-4-(trifluoromethyl)phenol in 88% yield.

References

[1] Patent: US4607128, 1986, A
[2] Journal of the American Chemical Society, 2009, vol. 131, p. 4031 - 4041
[3] Patent: CN107915584, 2018, A. Location in patent: Paragraph 0025; 0026; 0027; 0028
[4] Patent: CN108276254, 2018, A. Location in patent: Paragraph 0012; 0013; 0014; 0015
[5] Patent: US4076741, 1978, A

3-Chloro-4-hydroxybenzotrifluoride Preparation Products And Raw materials

Raw materials

4-Trifluoromethylphenol 2H-Pyran, 2-[2-chloro-4-(trifluoromethyl)phenoxy]tetrahydro- N-Chlorosuccinimide Zirconium tetrachloride Dichloromethane

Preparation Products

Acifluorfen Lactofen 4-Nitrophenol

3-Chloro-4-hydroxybenzotrifluoride Suppliers

Global Suppliers ( 167)
Supplier Tel Email Country ProdList Advantage
Shanghai Hongle Biotechnology Co., Ltd 021-56145923; 4001631568 sales@honglebiotech.com China 1036 58
Wuhan Roche Technology Development Co., Ltd., 18986168071; 18986168071 18986168071@163.com China 98 55
Shanghai Haozhixiang Biotechnology Co., Ltd 526763801 13301653310 526763801@qq.com China 7983 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Shanghai Hongle Biotechnology Co., Ltd 58
Wuhan Roche Technology Development Co., Ltd., 55
Shanghai Haozhixiang Biotechnology Co., Ltd 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 3-Chloro-4-hydroxybenzotrifluoride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-4-hydroxybenzotrifluoride pictures 2026-07-21 3-Chloro-4-hydroxybenzotrifluoride
35852-58-5
 1G 98% 20TONS Hubei Lidu New Material Technology Co., Ltd
3-Chloro-4-hydroxybenzotrifluoride pictures 2026-02-02 3-Chloro-4-hydroxybenzotrifluoride
35852-58-5
 50mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
3-Chloro-4-hydroxybenzotrifluoride pictures 2019-12-25 3-Chloro-4-hydroxybenzotrifluoride
35852-58-5
 $1.00 1g 99% 1000KGS Career Henan Chemical Co

3-Chloro-4-hydroxybenzotrifluoride Spectrum

3-Chloro-4-hydroxybenzotrifluoride(35852-58-5)1HNMR3-Chloro-4-hydroxybenzotrifluoride(35852-58-5)19FNMR

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3-Chloro-4-hydroxybenzotrifluoride 98% 3-Chloro-4-hydroxybenzotrifluoride98% 3-CHLORO-4-HYDROXYBENZOTRIFLUORIDE 2-Chloro-4-(trifuloromethyl)phenol 2-Chloro-4-(trifluoromethyl)phenol, 3-Chloro-4-hydroxy-alpha,alpha,alpha-trifluorotoluene 3-Chloro-4-hydroxybenzotrifluoride[2-Chloro-4-(trifluoroMethyl)phenol] 3-Chloro-4-hydroxybe 2-chloro-4-trifluoromethylphenl Phenol, 2-chloro-4-(trifluoromethyl)- 3-chloro-4-hydroxytrifluoromethylene 2-chloro-4-(trifluoromethyl)phenol - [C86577] 2-CHLORO-4-(TRIFLUOROMETHYL)PHENOL 35852-58-5 C7H4OClF3 Fluorine series Phenol&Thiophenol&Mercaptan