2-Hydroxycinnamaldehyde
- CAS No.
- 3541-42-2
- Chemical Name:
- 2-Hydroxycinnamaldehyde
- Synonyms
- Hydroxycinnamaldehyde;AT-51105;AKOS BC-1812;o-hydroxycinnamaldehyde;o-hydroxy-cinnamaldehyd;2-Hydroxycinnamaldehyde;2-hydroxycinnamicaldehyde;2-HYDROXYCINNAMALDEHYDE 97+%;3-(2-hydroxyphenyl)-2-propena;3-(2-HYDROXYPHENYL)-2-PROPENAL
- CBNumber:
- CB3300684
- Molecular Formula:
- C9H8O2
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD01736614
- MOL File:
- 3541-42-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 126 °C |
|---|---|
| Boiling point | 311.3±17.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 8.99±0.35(Predicted) |
| color | Yellow to Dark Yellow |
| LogP | 1.674 (est) |
2-Hydroxycinnamaldehyde price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H0952 | 2-Hydroxycinnamaldehyde >98.0%(HPLC) | 3541-42-2 | 1g | $597 | 2026-04-30 | Buy |
| Biosynth | DAA54142 | 2-Hydroxycinnamaldehyde | 3541-42-2 | 50mg | $188 | 2026-06-04 | Buy |
| Biosynth | DAA54142 | 2-Hydroxycinnamaldehyde | 3541-42-2 | 100mg | $283 | 2026-06-04 | Buy |
| Biosynth | DAA54142 | 2-Hydroxycinnamaldehyde | 3541-42-2 | 250mg | $590 | 2026-06-04 | Buy |
| Biosynth | DAA54142 | 2-Hydroxycinnamaldehyde | 3541-42-2 | 500mg | $945 | 2026-06-04 | Buy |
2-Hydroxycinnamaldehyde Chemical Properties, Uses, Production
Uses
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3].
Definition
ChEBI: (E)-3-(2-Hydroxyphenyl)-2-propenal is a member of cinnamaldehydes.
Synthesis Reference(s)
Synthetic Communications, 34, p. 1223, 2004 DOI: 10.1081/SCC-120030309
Synthesis
To a solution of 2-hydroxybenzaldehyde (10 g, 81.8 mmol) in THF (150 ml) was added (formylmethylene)triphenylphosphine (24.89 g, 81.8 mmol) at room temperature. The resulting reaction mixture was refluxed at 100 C for 20 hours. The reaction mixture was cooled to room temperature and extracted with water (200 ml) and ethyl acetate (3 x 150 ml). The combined organic phases were washed with water (150 ml), brine (150 ml), dried with sodium sulfate and concentrated in vacuum to give the desired crude product. The crude product was purified by column chromatography using normal phase silica gel. The desired product was eluted in a hexane solution of about 20-30% ethyl acetate. The product grade was evaporated to give 8.7 g (yield, 71.86%) of the desired compound as a yellow solid.
References
[1] Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84. DOI:10.1021/np400216m
[2] Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55. DOI:10.1016/j.canlet.2018.07.015
[3] Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884. DOI:10.1038/s12276-021-00620-z
2-Hydroxycinnamaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxycinnamaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| China Langchem Inc. | 021-58956006,021-58950017 15800617331 | sales@langchem.com | China | 209 | 57 |
| Aemon Chemical | 0086-755-86198205 | acinfo@aemonchem.com | China | 1928 | 57 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from 2-Hydroxycinnamaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | 2-Hydroxycinnamaldehyde
3541-42-2
|
$180.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-05-28 | 2-HYDROXYCINNAMALDEHYDE
3541-42-2
|
$9.00 | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-07-20 | 2-HydroxycinnaMaldehyde
3541-42-2
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-Hydroxycinnamaldehyde
3541-42-2
- $180.00
- TargetMol Chemicals Inc.
-
- 2-HYDROXYCINNAMALDEHYDE
3541-42-2
- $9.00
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 2-HydroxycinnaMaldehyde
3541-42-2
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
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