2'-Methoxycinnamaldehyde
- CAS No.
- 1504-74-1
- Chemical Name:
- 2'-Methoxycinnamaldehyde
- Synonyms
- 2-METHOXYCINNAMALDEHYDE;O-METHOXYCINNAMALDEHYDE;O-METHOXY CINNAMIC ALDEHYDE;FEMA 3181;(E)-2-Methoxycinnamaldehyde;AKOS BBS-00003213;o-MethoxycinnamaL;3-(o-Anisyl)propenal;2-Methoxyciamaldehyde;O-Ethoxycinnamaldehyde
- CBNumber:
- CB5356650
- Molecular Formula:
- C10H10O2
- Molecular Weight:
- 162.19
- MDL Number:
- MFCD00007001
- MOL File:
- 1504-74-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 44-48 °C(lit.) |
|---|---|
| Boiling point | 160-161 °C12 mm Hg(lit.) |
| Density | 1.0281 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| FEMA | 3181 | O-METHOXYCINNAMALDEHYDE |
| FLAVIS Number | 05.048 | 2-Methoxycinnamaldehyde |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Sparingly) |
| form | Solid |
| color | Yellow |
| Odor | at 100.00 %. sweet cinnamon cassia oily woody paper |
| Odor Type | spicy |
| biological source | synthetic |
| JECFA Number | 688 |
| Cosmetics Ingredients Functions |
PERFUMING ANTIOXIDANT |
| InChI | 1S/C10H10O2/c1-12-10-7-3-2-5-9(10)6-4-8-11/h2-8H,1H3/b6-4+ |
| InChIKey | KKVZAVRSVHUSPL-GQCTYLIASA-N |
| SMILES | COc1ccccc1\C=C\C=O |
| LogP | 2.13 |
| Substances Added to Food (formerly EAFUS) | O-METHOXYCINNAMALDEHYDE |
| FDA 21 CFR | 172.515 |
| CAS DataBase Reference | 1504-74-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4940G3R6HE |
| NIST Chemistry Reference | 2-Propenal, 3-(2-methoxyphenyl)-(1504-74-1) |
| EPA Substance Registry System | o-Methoxycinnamaldehyde (1504-74-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 2 |
| RTECS | GD6590000 |
| TSCA | TSCA listed |
| HS Code | 29124990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2'-Methoxycinnamaldehyde price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W318101 | 2-Methoxycinnamaldehyde natural, 98%, FG | 1504-74-1 | 1 each | $62.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | W318101 | 2-Methoxycinnamaldehyde natural, 98%, FG | 1504-74-1 | 100g | $88.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | W318101 | 2-Methoxycinnamaldehyde natural, 98%, FG | 1504-74-1 | 1kg | $227 | 2026-04-30 | Buy |
| Sigma-Aldrich | W318101 | 2-Methoxycinnamaldehyde natural, 98%, FG | 1504-74-1 | 10Kg | $1700 | 2026-04-30 | Buy |
| Sigma-Aldrich | W318101 | 2-Methoxycinnamaldehyde natural, 98%, FG | 1504-74-1 | 25kg | $3790 | 2026-04-30 | Buy |
2'-Methoxycinnamaldehyde Chemical Properties, Uses, Production
Uses
o-Methoxycinnamaldehyde is a food flavoring permitted for use according to GB2760-1997.
Description
o-Methoxycinnamaldehyde has a sweet, warm, spicy-floral odor with fruity undertones. It has a sweet, spicy, warm flavor, somewhat pungent above 200 - 300 ppm. It is formed after a long contact period between salicylaldehyde and acetaldehyde in diluted alkaline solution; it can be formed by condensation of salicylaldehyde methylether with acetaldehyde under alkaline conditions; from the corresponding oxime.
Chemical Properties
o-Methoxycinnamaldehyde has a sweet, warm, spicy-floral odor with fruity undernotes. It has a sweet, spicy, warm flavor and is somewhat pungent above 200 to 300ppm.
Occurrence
Reported found in cinnamon oil (Cinnamomum cassia Nees ex Bl.) from which it is separated as stearoptene; in cinnamon bark and leaf.
Definition
ChEBI: Cassiastearoptene is a member of cinnamaldehydes.
Preparation
It is formed after a long contact period between salicylaldehyde and acetaldehyde in diluted alkaline solution; it may also be formed by condensation of salicylaldehyde methylether with acetaldehyde under alkaline conditions; from the corresponding oxime. It may be isolated and purified from powdered cinnamon.
Taste threshold values
Taste characteristics at 50 ppm: warm, spicy, cinnamon and clove-like.
General Description
Yellow crystals.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Aldehydes, such as 2'-Methoxycinnamaldehyde, are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation.
Fire Hazard
2'-Methoxycinnamaldehyde is flammable.
Synthesis
1504-61-6
1504-74-1
The general procedure for the synthesis of 2'-methoxycinnamaldehyde from the compound (CAS:1504-61-6) is as follows: alcohol (5.0 mmol), copper acetate (Cu(OAc)2, 9.1 mg, 0.05 mmol), and TEMPO (7.8 mg, 0.05 mmol) were mixed in a mixture of acetonitrile (CH3CN, 5 mL) and water (H2O, 10 mL) in a mixed solvents at room temperature with stirring for the indicated times. The progress of the reaction was monitored by thin-layer chromatography (TLC) with the eluent ratio of petroleum ether/ethyl acetate = 4/1. After completion of the reaction, the reaction mixture was extracted by adding dichloromethane (10 mL) to the reaction mixture. The organic phase was separated and the aqueous phase was extracted twice more with dichloromethane (10 mL x 2). All organic layers were combined, dried with anhydrous sodium sulfate and concentrated to obtain the crude product. The crude product was purified by column chromatography with the eluent ratio of petroleum ether/ethyl acetate=10/1, and the target product 2'-methoxycinnamaldehyde was finally obtained.
target
P450 (e.g. CYP17)
References
[1] Tetrahedron Letters, 2014, vol. 55, # 10, p. 1677 - 1681
[2] European Journal of Organic Chemistry, 2016, vol. 2016, # 20, p. 3401 - 3407
[3] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 19, p. 2473 - 2476
2'-Methoxycinnamaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-69106960 13701823997 | 13701823733@163.com | China | 4634 | 60 |
| Zaoyang Cixiang Medical Technology Co., Ltd | 19871689299 | 1242417277@qq.com | China | 52 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 2'-Methoxycinnamaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-20 | 2-methoxycinnamaldehyde
1504-74-1
|
$39.00 | 98.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | 2′-Methoxycinnamaldehyde
1504-74-1
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 2'-Methoxycinnamaldehyde
1504-74-1
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-methoxycinnamaldehyde
1504-74-1
- $39.00
- 98.00%
- TargetMol Chemicals Inc.
-
- 2′-Methoxycinnamaldehyde
1504-74-1
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 2'-Methoxycinnamaldehyde
1504-74-1
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
