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2-Chloro-4,6-dimethylpyrimidine

2-Chloro-4,6-dimethylpyrimidine Structure
2-Chloro-4,6-dimethylpyrimidine structure
CAS No.
4472-44-0
Chemical Name:
2-Chloro-4,6-dimethylpyrimidine
Synonyms
NSC 49016;AKOS BBS-00002114;IFLAB-BB F2130-0005;CHEMBRDG-BB 4900312;2-chloro-4,6-dimethyl-pyrimidin;2-CHLORO-4,6-DIMETHYLPYRIMIDINE;2-Chloro-3,5-dimethylpyrimidine;4,6-DiMethyl-2-chloropyriMidine;2-Chloro-4,6-dimethyl-1,3-diazine;Pyrimidine, 2-chloro-4,6-dimethyl-
CBNumber:
CB3311477
Molecular Formula:
C6H7ClN2
Molecular Weight:
142.59
MDL Number:
MFCD00023199
MOL File:
4472-44-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:27:10
Product description Number Pack Size Price
2-Chloro-4,6-dimethylpyrimidine >98.0%(GC) C2199 5g $117
2-Chloro-4,6-dimethylpyrimidine >98.0%(GC) C2199 25g $475
2-Chloro-4,6-dimethylpyrimidine 99+% (GC) ≥99%(GC) 230148 1g $156
2-Chloro-4,6-dimethylpyrimidine 99+% (GC) ≥99%(GC) 230148 5g $170
2-Chloro-4,6-dimethylpyrimidine 99+% (GC) ≥99%(GC) 230148 25g $262
More product size
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2-Chloro-4,6-dimethylpyrimidine Properties

Melting point 34-36
Boiling point 212 °C
Density 1,03g/cm
refractive index 1,428
Flash point 110℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Methanol
form Powder, Crystalline Powder or Low Melting Solid
pka 0.09±0.30(Predicted)
color White to yellow
InChIKey RZVPFDOTMFYQHR-UHFFFAOYSA-N
CAS DataBase Reference 4472-44-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII XWF9HK9FMS
NIST Chemistry Reference 2-Chloro-4,6-dimethylpyrimidine(4472-44-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H302-H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-22
Safety Statements  26-36-37
RIDADR  UN 2265
RTECS  UV8000000
HazardClass  IRRITANT
HS Code  29335990
REACH Registrations Active
NFPA 704
1
2 0

2-Chloro-4,6-dimethylpyrimidine price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2199 2-Chloro-4,6-dimethylpyrimidine >98.0%(GC) 4472-44-0 5g $117 2026-04-30 Buy
TCI Chemical C2199 2-Chloro-4,6-dimethylpyrimidine >98.0%(GC) 4472-44-0 25g $475 2026-04-30 Buy
Usbiological 230148 2-Chloro-4,6-dimethylpyrimidine 99+% (GC) ≥99%(GC) 4472-44-0 1g $156 2026-06-03 Buy
Usbiological 230148 2-Chloro-4,6-dimethylpyrimidine 99+% (GC) ≥99%(GC) 4472-44-0 5g $170 2026-06-03 Buy
Usbiological 230148 2-Chloro-4,6-dimethylpyrimidine 99+% (GC) ≥99%(GC) 4472-44-0 25g $262 2026-06-03 Buy
Product number Packaging Price Buy
C2199 5g $117 Buy
C2199 25g $475 Buy
230148 1g $156 Buy
230148 5g $170 Buy
230148 25g $262 Buy

2-Chloro-4,6-dimethylpyrimidine Chemical Properties,Uses,Production

Uses

2-Chloro-4,6-dimethylpyrimidine is a chlorinated pyrimidine with antiviral activity.

Synthesis

4,6-DIMETHYL-2-HYDROXYPYRIMIDINE HYDROCHLORIDE

34289-60-6

2-Chloro-4,6-dimethylpyrimidine

4472-44-0

General procedure for the synthesis of 2-chloro-4,6-dimethylpyrimidine from 4,6-dimethyl-2-hydroxypyrimidine hydrochloride: 4,6-dimethyl-2-hydroxypyrimidine hydrochloride (1998 mg, 12.44 mmol) was mixed with phosphorochloridic acid (20 mL) and the reaction was carried out at reflux for 10 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by distillation under reduced pressure to give a brown oil. The reaction mixture was cooled in an ice bath and concentrated aqueous potassium hydroxide solution was added slowly and dropwise to a pH of about 8 (detected by litmus paper). Diethyl ether (30 mL) was then added and stirring was continued for 2.5 hours. The aqueous layer was separated and extracted with ether (3 x 30 mL) and ethyl acetate (3 x 30 mL), respectively. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting yellow liquid was placed in an ice bath and dried under vacuum to give 2-chloro-4,6-dimethylpyrimidine (1606 mg, 91% yield) as yellow crystals.1H NMR (400 MHz, DMSO-d6) δ 7.33 (s, 1H), 2.42 (s, 6H).

References

[1] PLoS ONE, 2018, vol. 13, # 1,
[2] Journal of Organic Chemistry, 2002, vol. 67, # 18, p. 6550 - 6552
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2008, vol. 183, # 4, p. 986 - 991
[4] Journal of Organometallic Chemistry, 2013, vol. 732, p. 137 - 141

2-Chloro-4,6-dimethylpyrimidine Preparation Products And Raw materials

Raw materials

4,6-DIMETHYL-2-HYDROXYPYRIMIDINE HYDROCHLORIDE 2-Chloro-4,6-dimethoxypyrimidine

Preparation Products

N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N-ETHYLBENZENE-1,4-DIAMINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N-METHYLBENZENE-1,4-DIAMINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)BENZENE-1,4-DIAMINE 4,6-Dimethylpyrimidine-2-carbonitrile PYRIMIDINE-4,6-DICARBOYL DICHLORIDE
N-(4-NITROPHENYL)-4,6-DIMETHYL-2-PYRIMIDINAMINE 2-Amino-4,6-dimethylpyrimidine Pyrimidine, 2-fluoro-4,6-dimethyl- (9CI) 4,6-Dimethyl-2-iodopyrimidine N-(4-CHLOROPHENYL)-N-(4,6-DIMETHYLPYRIMIDIN-2-YL)GUANIDINE
benzyl-(4,6-dimethyl-pyrimidin-2-yl)-amine

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2-Chloro-4,6-dimethylpyrimidine Suppliers

Global( 289)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2993 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14301 58
Dideu Industries Group Limited 		+8617392712697 1022@dideu.com China 29094 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9035 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58
Dideu Industries Group Limited 		58
Baoji Guokang Healthchem Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 2-Chloro-4,6-dimethylpyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4,6-dimethylpyrimidine pictures 2026-08-20 2-Chloro-4,6-dimethylpyrimidine
4472-44-0
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Chloro-4,6-dimethylpyrimidine pictures 2025-05-23 2-Chloro-4,6-dimethylpyrimidine
4472-44-0
 $50.00 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co Ltd
2-Chloro-4,6-dimethylpyrimidine pictures 2022-02-25 2-Chloro-4,6-dimethylpyrimidine
4472-44-0
 $3.90 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd

2-Chloro-4,6-dimethylpyrimidine Spectrum

2-Chloro-4,6-dimethylpyrimidine(4472-44-0)MS2-Chloro-4,6-dimethylpyrimidine(4472-44-0)1HNMR2-Chloro-4,6-dimethylpyrimidine(4472-44-0)IR12-Chloro-4,6-dimethylpyrimidine(4472-44-0)IR2

4472-44-0(2-Chloro-4,6-dimethylpyrimidine)Related Search:

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4,6-DIMETHYLPYRIMIDINE ETHYL 2-CHLORO-6-METHYLPYRIMIDINE-4-CARBOXYLATE 2-Chloro-4,6-diphenylpyrimidine

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CHEMBRDG-BB 4900312 IFLAB-BB F2130-0005 2-CHLORO-4,6-DIMETHYLPYRIMIDINE 2-chloro-4,6-dimethyl-pyrimidin Pyrimidine, 2-chloro-4,6-dimethyl- AKOS BBS-00002114 Pyrimidine, 2-chloro-4,6-dimethyl- (6CI,7CI,8CI,9CI) 2-CHLORO-4,6-DIMETHYLPYRIMIDINE,98.0+%(GC) 2-Chloro-3,5-dimethylpyrimidine 2-chloro-4,6-dimethylpyrimidine(SALTDATA: FREE) 2-Chloro-4,6-dimethyl-1,3-diazine 2-Chloro-4,6-diMethylpyriMidine, 98%+ 4,6-DiMethyl-2-chloropyriMidine NSC 49016 JR-8782, 2-Chloro-4,6-dimethylpyrimidine, 97% 2-Chloro-4,6-dimethylpyrimidine > 2-Chloro-4,6-dimethylpyrimidine ISO 9001：2015 REACH 4472-44-0 C6H7ClN2 HETERO CHLORIDE Pyrazines, Pyrimidines & Pyridazines Heterocycle-Pyrimidine series PYRIMIDINE pharmacetical Halides Pyrazines, Pyrimidines & Pyridazines