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2,2-Dimethyl-piperazine

2,2-Dimethyl-piperazine Structure
2,2-Dimethyl-piperazine structure
CAS No.
84477-72-5
Chemical Name:
2,2-Dimethyl-piperazine
Synonyms
2-dimethylpiperazine;2,2-Dimethyl-piperazine;Piperazine, 2,2-dimethyl-;cis-2,2-dimethylpiperazine;2,2-DiMethyl-piperazine 2HCl;2,2-DIMETHYL-PIPERAZINE ISO 9001：2015 REACH
CBNumber:
CB3312131
Molecular Formula:
C6H14N2
Molecular Weight:
114.19
MDL Number:
MFCD06798288
MOL File:
84477-72-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:59
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2,2-Dimethyl-piperazine Properties

Boiling point 155.2±8.0 °C(Predicted)
Density 0.833±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 9.38±0.40(Predicted)
form Solid
color Pale Yellow Low Melting
InChI InChI=1S/C6H14N2/c1-6(2)5-7-3-4-8-6/h7-8H,3-5H2,1-2H3
InChIKey PIPWSBOFSUJCCO-UHFFFAOYSA-N
SMILES N1CCNCC1(C)C
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H315-H318-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501
Hazard Codes  Xi,N
Risk Statements  42-51/53
Safety Statements  61
RIDADR  UN3077
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Aquatic Chronic 2

2,2-Dimethyl-piperazine price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 273994 2,2-Dimethyl-piperazine Asreported 84477-72-5 250mg $358 2026-06-03 Buy
Usbiological 273994 2,2-Dimethyl-piperazine Asreported 84477-72-5 500mg $496 2026-06-03 Buy
Usbiological 273994 2,2-Dimethyl-piperazine Asreported 84477-72-5 1g $847 2026-06-03 Buy
Usbiological 273994 2,2-Dimethyl-piperazine Asreported 84477-72-5 2g $1313 2026-06-03 Buy
Usbiological 273994 2,2-Dimethyl-piperazine Asreported 84477-72-5 5g $1895 2026-06-03 Buy
Product number Packaging Price Buy
273994 250mg $358 Buy
273994 500mg $496 Buy
273994 1g $847 Buy
273994 2g $1313 Buy
273994 5g $1895 Buy

2,2-Dimethyl-piperazine Chemical Properties,Uses,Production

Uses

2,2-Dimethylpiperazine is a chemical reagent used in the preparation of non-covalent NAAA inhibitors used as a protective agent for the development of multiple sclerosis.

Synthesis

3,3-DIMETHYLPIPERAZIN-2-ONE

22476-74-0

2,2-DIMETHYL-PIPERAZINE

84477-72-5

Example 4 Synthesis of 2,2-dimethylpiperazine: 3,3-dimethylpiperazin-2-one (8.28 kg, 64.6 mol) was mixed with tetrahydrofuran (THF, 60 kg) and heated to 50-60 °C to form a slightly turbid solution. LiAlH4 (250 g, encapsulated in a soluble plastic bag) was slowly added to the stirring THF (50 kg) under nitrogen protection and a slow gas release was observed. After the gas release ceased, the addition of LiAlH4 (total 3.0 kg, 79.1 mol) was continued and the reaction was exothermic causing the temperature to rise from 22°C to 50°C. Subsequently, a solution of 3,3-dimethylpiperazin-2-one was added slowly and dropwise over a period of 2 h at 41-59 °C. The solution was then added to the suspension over a period of 2 h. The solution was then added to the suspension over a period of 1 h at 41-59 °C. After addition, the suspension was continued to be stirred at 59 °C (jacket temperature 60 °C) for 1 hour. After the reaction mixture was cooled, water (3 L) was added slowly over a period of 2 h. The temperature was controlled to be lower than 25 °C (cooling by EPO, jacket temperature 0 °C). Next, 15% aqueous sodium hydroxide solution (3.50 kg) was added over 20 min at 23 °C and cooled if necessary. Subsequently, water (9 L) was added within half an hour, cooling was required to maintain the temperature, and the mixture was stirred overnight under nitrogen protection. Celite filter (4 kg) was added, the mixture was filtered and the filter cake was washed with THF (40 kg). The filtrates were combined and concentrated in a reactor until the temperature in the reactor reached 70 °C (distillation temperature 66 °C, pressure 800 mbar). The residue (12.8 kg) was further concentrated by rotary evaporator to about 10 L. Finally, the mixture was fractionated at atmospheric pressure and the 163-164 °C fraction was collected to give 5.3 kg of product (72% yield). The structure of the product was confirmed by NMR.

References

[1] Patent: WO2005/16900, 2005, A1. Location in patent: Page/Page column 27-28
[2] Patent: WO2006/86986, 2006, A1. Location in patent: Page/Page column 15
[3] Patent: WO2006/86985, 2006, A1. Location in patent: Page/Page column 14-15
[4] Patent: WO2006/86984, 2006, A1. Location in patent: Page/Page column 20
[5] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 113; 114

2,2-Dimethyl-piperazine Preparation Products And Raw materials

Raw materials

3,3-Dimethylpiperazin-2-one Lithium Aluminum Hydride Tetrahydrofuran

Preparation Products

1-Boc-2,2-dimethyl-piperazine 1-Boc-3,3-dimethylpiperazine

2,2-Dimethyl-piperazine Suppliers

Global( 143)Suppliers
Supplier Tel Email Country ProdList Advantage
Gansu Songsheng Pharmaceutical Co. , Ltd. 13705130158 sales@unitechemical.com China 145 58
Guangzhou Kaitu Chemical Co., Ltd 18933936954 kang.sun@cato-chem.com China 287 58
Shaoyuan Technology (Shanghai) Co., Ltd. 021-50795510 4000665055 marketing@accelachem.com China 9721 58
Cato Research Chemicals Inc. 020-81960175-877 18933936954 tianwen.zhan@cato-chem.com China 7335 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
China Langchem Inc. 0086-21-58956006 China 7798 57
Supplier Advantage
Gansu Songsheng Pharmaceutical Co. , Ltd. 58
Guangzhou Kaitu Chemical Co., Ltd 58
Shaoyuan Technology (Shanghai) Co., Ltd. 58
Cato Research Chemicals Inc. 58
J & K SCIENTIFIC LTD. 76
ForeChem (Nantong) Technology Co.,Ltd. 61
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Shanghai Ennopharm Co., Ltd. 65
China Langchem Inc. 57

View Lastest Price from 2,2-Dimethyl-piperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,2-DIMETHYL-PIPERAZINE pictures 2026-08-20 2,2-DIMETHYL-PIPERAZINE
84477-72-5
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
2,2-Dimethylpiperazine pictures 2022-02-25 2,2-Dimethylpiperazine
84477-72-5
 $2.90 1KG 99% 1000kg Hong Kong Tiansheng New Material Trading Co., Ltd
2,2-Dimethylpiperazine pictures 2022-02-25 2,2-Dimethylpiperazine
84477-72-5
 $2.90 1KG 98% 10KG Hong Kong Tiansheng New Material Trading Co., Ltd

2,2-Dimethyl-piperazine Spectrum

2,2-DIMETHYL-PIPERAZINE(84477-72-5)1HNMR

84477-72-5(2,2-Dimethyl-piperazine)Related Search:

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1-Boc-3,5-dimethyl-piperazine 1,2-Dimethyl-piperazine paraherquamide (2S,5R)-1-Boc-2,5-Dimethyl-Piperazine quinocarcin
6,9-Diazaspiro[4.5]decane-7,10-dione,8-methyl-(9CI) saframycin D (2S,5R)-2,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester 1-Cbz-3,3-dimethyl-piperazine 5-(2,2-Dimethyl-3-oxo-piperazin-1-yl)-5-oxo-pentanoic acid
(2R,5R)-2,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester (2R,5S)-2,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester 3,3-Dimethylpiperazin-2-one

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2,2-DiMethyl-piperazine 2HCl Piperazine, 2,2-dimethyl- 2-dimethylpiperazine cis-2,2-dimethylpiperazine 2,2-DIMETHYL-PIPERAZINE ISO 9001：2015 REACH 2,2-Dimethyl-piperazine 84477-72-5 pharmacetical