UKI-1
- CAS No.
- 220355-63-5
- Chemical Name:
- UKI-1
- Synonyms
- UKI-1;UKI-1C;UKI 1,UKI1;Upamostat Impurity 4;ethyl (S)-4-(3-(3-carbamimidoylphenyl)-2-((2,4,6-triisopropylphenyl)sulfonamido)propanoyl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester
- CBNumber:
- CB33133353
- Molecular Formula:
- C32H47N5O5S
- Molecular Weight:
- 613.81
- MDL Number:
- MOL File:
- 220355-63-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 745.5±70.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 28 mg/mL (45.62 mM) |
| form | Solid |
| pka | 9.76±0.50(Predicted) |
| color | White to off-white |
| FDA UNII | 00LOF6890B |
UKI-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BU178186 | UKI-1 | 220355-63-5 | 1mg | $329.82 | 2026-06-04 | Buy |
| Biosynth | BU178186 | UKI-1 | 220355-63-5 | 5mg | $1401.8 | 2026-06-04 | Buy |
| Biosynth | BU178186 | UKI-1 | 220355-63-5 | 10mg | $2242.8 | 2026-06-04 | Buy |
| ChemScene | CS-5726 | UKI-1 96.13% | 220355-63-5 | 1mg | $195 | 2026-06-04 | Buy |
| ChemScene | CS-5726 | UKI-1 96.13% | 220355-63-5 | 5mg | $455 | 2026-06-04 | Buy |
UKI-1 Chemical Properties, Uses, Production
Uses
UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells[1][2].
in vivo
UKI-1 (WX-UK1) treatment has antimetastatic activities that significantly reduces the number of metastatic lesions and tumor growth in metastasizing rat pancreatic and mammary adenocarcinoma tumor models[1].
References
[1] Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24. DOI:10.1002/ijc.20192
[2] Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75. DOI:10.1006/jmbi.2000.3966
UKI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
UKI-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2377 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Beijing ECom Technology Co., Ltd. | 17710328343 | 3004011422@qq.com | China | 2567 | 58 |
