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3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one

3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one structure

CAS No.: 1628224-94-1

Chemical Name:: 3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one

Synonyms: EOS-62164;Thrombin inhibitor 6;3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one;2(1H)-Pyridinone, 3-[5-[[(5-chloro-2-thienyl)methyl]amino]-1-(2,2-dimethyl-1-oxopropyl)-1H-pyrazol-3-yl]-

CBNumber:: CB33142672

Molecular Formula:: C18H19ClN4O2S

Molecular Weight:: 390.89

MDL Number:

MOL File:: 1628224-94-1.mol

MSDS File:: SDS

Last updated:2026-05-11 19:39:08

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3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one Properties

Density	1.38±0.1 g/cm3(Predicted)
pka	10.30±0.10(Predicted)

3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one Chemical Properties, Uses, Production

Uses

Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].

in vivo

Thrombin inhibitor 6 (compound 73) (9 mg/kg, i.v.) prolongs the tail bleeding time in CD-1 mice^[1].
Thrombin inhibitor 6 (5 mg/kg, p.o.) shows F(%) of 22.8%, AUC of 713.3 h.ng/mL and C_max of 127 ng/mL in male CD-1 mice^[1].

Animal Model:	CD-1 mice^[1]
Dosage:	9 mg/kg
Administration:	Intravenous injection (i.v.)
Result:	The mice bled for 25 min following transection. Led to 1.5-fold increase of liberated whole blood cells.

References

[1] Short KM, et al. Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors. Eur J Med Chem. 2022 Oct 27;246:114855. DOI:10.1016/j.ejmech.2022.114855

3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan elephant international trading co., LTD		13006575422@163.com	China	6347	58
Shanghai zhigan biotechnology co., LTD		zhiqianbio@126.com	China	19765	58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd.	hanfangpharma@126.com 15165037910	hanfangpharma@126.com	China	25800	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58

Supplier	Advantage
Jinan elephant international trading co., LTD	58
Shanghai zhigan biotechnology co., LTD	58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Latest Price from 3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	Thrombin inhibitor 6 1628224-94-1	$1520.00-2500.00			10g	TargetMol Chemicals Inc.

Thrombin inhibitor 6
1628224-94-1
$1520.00-2500.00
TargetMol Chemicals Inc.

1628224-94-1 (3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one) Related Search:

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3-(5-(((5-chlorothiophen-2-yl)methyl)amino)-1-pivaloyl-1H-pyrazol-3-yl)pyridin-2(1H)-one EOS-62164 2(1H)-Pyridinone, 3-[5-[[(5-chloro-2-thienyl)methyl]amino]-1-(2,2-dimethyl-1-oxopropyl)-1H-pyrazol-3-yl]- Thrombin inhibitor 6 1628224-94-1