GNE-140 (racemate)
- CAS No.
- 1802977-61-2
- Chemical Name:
- GNE-140 (racemate)
- Synonyms
- GNE-140 (racemate);GNE-140 racemate (GNE 140 racemate;3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione;2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-
- CBNumber:
- CB33152079
- Molecular Formula:
- C25H23ClN2O3S2
- Molecular Weight:
- 499.04
- MDL Number:
- MOL File:
- 1802977-61-2.mol
GNE-140 (racemate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5958 | GNE-140(racemate) 99.66% | 1802977-61-2 | 1mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-5958 | GNE-140(racemate) 99.66% | 1802977-61-2 | 5mg | $220 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BG166816 | GNE 140 | 1802977-61-2 | 10mg | $225 | 2021-12-16 | Buy |
| AK Scientific | 2927EF | GNE-140(racemate) | 1802977-61-2 | 10mg | $353 | 2021-12-16 | Buy |
| ChemScene | CS-5958 | GNE-140(racemate) 99.66% | 1802977-61-2 | 10mg | $370 | 2021-12-16 | Buy |
GNE-140 (racemate) Chemical Properties,Uses,Production
Description
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor
Uses
GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor[1][2].
in vitro
Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion.
References
[1] ?dralevi? M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293(41):15947-15961. DOI:10.1074/jbc.RA118.004180
[2] Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901. DOI:10.1021/acsmedchemlett.6b00190
GNE-140 (racemate) Preparation Products And Raw materials
Raw materials
Preparation Products
GNE-140 (racemate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | 16728589@qq.com | CHINA | 272 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |