CE3F4
- CAS No.
- 143703-25-7
- Chemical Name:
- CE3F4
- Synonyms
- CE3F4;CE3F4 >=98% (HPLC);CE3F4, 10 mM in DMSO;inhibit,Inhibitor,CE3F4,CE-3F4;5,7-Dibromo-6-fluoro-2-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde;5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde;5,7-dibromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline-1-carbaldehyde;1(2H)-Quinolinecarboxaldehyde, 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-
- CBNumber:
- CB33152589
- Molecular Formula:
- C11H10Br2FNO
- Molecular Weight:
- 351.01
- MDL Number:
- MOL File:
- 143703-25-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| color | White to off-white |
| InChI | InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3 |
| InChIKey | ZZLQPWXVZCPUGC-UHFFFAOYSA-N |
| SMILES | N1(C=O)C2=C(C(Br)=C(F)C(Br)=C2)CCC1C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H411 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 |
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| NFPA 704 |
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CE3F4 price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2041 | CE3F4 ≥98% (HPLC) | 143703-25-7 | 5 mg | $85.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2041 | CE3F4 ≥98% (HPLC) | 143703-25-7 | 25 mg | $347 | 2026-04-30 | Buy |
| Cayman Chemical | 17767 | CE3F4 ≥98% | 143703-25-7 | 5mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 17767 | CE3F4 ≥98% | 143703-25-7 | 10mg | $161 | 2026-04-30 | Buy |
| Cayman Chemical | 17767 | CE3F4 ≥98% | 143703-25-7 | 50mg | $676 | 2026-04-30 | Buy |
CE3F4 Chemical Properties, Uses, Production
Uses
CE3F4 has been used as a selective exchange protein directly activated by cAMP isoform 1 (Epac1) inhibitor in cell proliferation assay to study the influence of Epac type I on cell proliferation of C6 cells (a model of glioma).
Biological Activity
CE3F4 is a tetrahydroquinoline derivative th at blocks agonist-stimulated Epac1 (exchange protein directly activated by cAMP isoform 1) guanine nucleotide exchange activity toward its effector Rap1 (IC50 = 23 μM; Epac agonist = 2 μM 8-CPT-2μ-O-Me-cAMP) by targeting agonist-bound Epac1 in an agonist-uncompetitive manner without affecting the GDP exchange on Rap1, Rap1-Epac1 interaction, or PKA type I/II activity (CβRIβ & CαRIIβ). CE3F4 (20 μM) effectively inhbits cellular Rap1 activation upon 10 μM Sp-8-pCPT-2μ-O-Me-cAMPS (Epac1-transfected HEK293 and r at neonatal cardiac myocytes) or 10 μM β-adrenergic receptor agonist isoprenaline stimulation (β1AR & Epac1 dually transfected HEK293). The isolated CE3F4 R enantiomer is reported to display 10-fold Epac1 selectivity over Epac2, and is 10-times more potent than the CE3F S enantiomer against Epac1.', 'Epac1 is a downstream effector of the cyclic adenosine monophosphate (cAMP) pathway.
in vivo
CE3F4 (1-3 mg/kg; through a catheter in the internal jugular vein) inhibits atrial fibrillation (AF) and CE3F4 (3 mg/kg; i.v.) inhibits ventricular arrhythmias[4].
CE3F4 (10 mg/kg; i.v.) improves cardiac function after myocardial infarction in mice[5].
| Animal Model: | Wild-type (WT) mice (induced AF after 20min of CE3F4 administration)[4] |
| Dosage: | 3 mg/kg and 1mg/kg |
| Administration: | Through a catheter in the internal jugular vein |
| Result: | Shortened the duration of the pacing-induced AF at 3mg/kg. |
| Animal Model: | Casq2-KO mice (premature ventricular contraction induced by isoproterenol injection 20min after CE3F4 administration)[4] |
| Dosage: | 3 mg/kg |
| Administration: | I.v. |
| Result: | Reduced the incidence of sympathetic activation-induced ventricular arrhythmias. |
storage
Store at -20°C
CE3F4 Preparation Products And Raw materials
Raw materials
Preparation Products
CE3F4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Nanjing LuoDa Chemical Co., Ltd | 025-66016961 13382082786; | China | 276 | 55 | |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 964 | 58 |
