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DE-7

DE-7 Structure
DE-7 structure
CAS No.
681490-93-7
Chemical Name:
DE-7
Synonyms
DE-7;Dilamanid intermediate;2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole;(R)-2-chloro-1-{(2-methyloxiran-2-yl)methyl}-4-nitro-1H-imidazole;1H-Imidazole, 2-chloro-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro-
CBNumber:
CB33154114
Molecular Formula:
C7H8ClN3O3
Molecular Weight:
217.61
MDL Number:
MOL File:
681490-93-7.mol
MSDS File:
SDS
Last updated:2026-05-28 03:02:10
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DE-7 Properties

Melting point 72-73 °C
Boiling point 393.9±38.0 °C(Predicted)
Density 1.68±0.1 g/cm3(Predicted)
storage temp. 2-8°C, stored under nitrogen
solubility Chloroform, DCM
pka -2.55±0.60(Predicted)
form Solid
color Off-White
optical activity Consistent with structure

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Danger
Hazard statements  H312-H303-H315-H319-H361-H372-H317-H351-H335-H336-H412
Precautionary statements  P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P312-P337+P313-P305+P351+P338-P362+P364-P333+P313-P302+P352+P312-P304+P340+P312-P403+P233-P405

DE-7 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 299097 (R)-2-Chloro-1-((2-methyloxiran-2-yl)methyl)-4-nitro-1H-imidazole 681490-93-7 250.00mg $36 2026-05-19 Buy
Matrix Scientific 299097 (R)-2-Chloro-1-((2-methyloxiran-2-yl)methyl)-4-nitro-1H-imidazole 681490-93-7 1.00g $82 2026-05-19 Buy
Matrix Scientific 299097 (R)-2-Chloro-1-((2-methyloxiran-2-yl)methyl)-4-nitro-1H-imidazole 681490-93-7 5.00g $284 2026-05-19 Buy
aablocks AA005ZEO (R)-2-Chloro-1-((2-methyloxiran-2-yl)methyl)-4-nitro-1H-imidazole 98% 681490-93-7 250mg $24 2026-05-28 Buy
aablocks AA005ZEO (R)-2-Chloro-1-((2-methyloxiran-2-yl)methyl)-4-nitro-1H-imidazole 95% 681490-93-7 1g $85 2026-05-28 Buy
Product number Packaging Price Buy
299097 250.00mg $36 Buy
299097 1.00g $82 Buy
299097 5.00g $284 Buy
AA005ZEO 250mg $24 Buy
AA005ZEO 1g $85 Buy

DE-7 Chemical Properties, Uses, Production

Uses

2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole is an intermediate in the synthesis of Delamanid (D230660), a novel anti-tuberculosis medication that inhibits mycolic acid synthesis and shows potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis.

DE-7 synthesis

683276-63-3
57531-37-0
681490-93-7
Synthesis of DE-7 from DE-6 and 2-Chloro-4-nitroimidazole

DE-7 Preparation Products And Raw materials

Raw materials

2-Chloro-4-nitroimidazole DE-6 (R)-3-(2-chloro-4-nitro-1H-imidazol-1-yl)-2-hydroxy-2-methylpropylmethanesulfonate (R)-2-chloro-1-(2,3-dihydroxy-2-methyl)-propyl-4-nitroimidazole (R)-2-chloro-1-[2-hydroxy-2-methyl-3-(4-nitrobenzoyloxy)]-propyl-4-nitroimidazole

Preparation Products

DE-7 Suppliers

Global Suppliers ( 22)
Supplier Tel Email Country ProdList Advantage
Chemipanda Bio-Tech Co., Ltd. +86-571-85224801; 13588483690 chemipanda2010@163.com China 98 62
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Lynnchem 86-(0)29-85992781 17792393971 info@lynnchem.com China 4578 58
Hubei Yangxin Medical Technology Co., Ltd. 15374522761 3003392093@yongstandards.com China 9995 55
Novachemistry 44-20819178-90 02081917890 info@novachemistry.com United Kingdom 4372 58
Jiangsu Heru Chemical Trading Co., Ltd. 18851404566(1497685734) 1497685734@qq.com China 75 58
Zhengzhou Acme Chemical Co., Ltd. 0371-63315541 13323832564 1443871971@qq.com China 9895 58
CD Chemical Group Limited +86-13651442114 info@codchem.com China 17253 58
Taizhou Nanfeng Pharmaceutical Research Institute nanfengpharma@126.co 18616377689 nanfengpharma@126.com China 20008 58
Shanghai Ruipu Medical Technology Co., Ltd 15895968936 1018762393@qq.com China 9992 58
Supplier Advantage
Chemipanda Bio-Tech Co., Ltd. 62
Amadis Chemical Company Limited 58
Lynnchem 58
Hubei Yangxin Medical Technology Co., Ltd. 55
Novachemistry 58
Jiangsu Heru Chemical Trading Co., Ltd. 58
Zhengzhou Acme Chemical Co., Ltd. 58
CD Chemical Group Limited 58
Taizhou Nanfeng Pharmaceutical Research Institute 58
Shanghai Ruipu Medical Technology Co., Ltd 58

DE-7 Spectrum

DE-7(681490-93-7)1HNMR

681490-93-7 (DE-7) Related Search:

1H-Imidazole, 4-nitro-1-(2-oxiranylmethyl)- Ornidazole Impurity 5 1H-Imidazole, 5-nitro-1-(2-oxiranylmethyl)- 1-(2,3-Epoxypropyl)-2-methyl-5-nitroimidazole 2-Nitro-1-(oxiranylmethyl)-1H-imidazole
3-Nitro-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-ol

1of2

DE-7 (R)-2-chloro-1-{(2-methyloxiran-2-yl)methyl}-4-nitro-1H-imidazole 2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole Dilamanid intermediate 1H-Imidazole, 2-chloro-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro- 681490-93-7