Volixibat potassium
- CAS No.
- 220334-14-5
- Chemical Name:
- Volixibat potassium
- Synonyms
- A-6 peptide;P1161 Angstrom6;Angstrom6 ，P1161;Volixibat potassium;Angstrom6/A6 Peptide;Volixibat potassium/A 6 (Peptide);A-6|||A 6 peptide|||A6|||A 6|||A6 peptide|||A-6 peptide;L-α-Glutamine, N2-acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl-L-prolyl-L-α-glutamyl-;(S)-N-((S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-2-((S)-2-((S)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-3-hydroxypropanamido)-4-methylpentanamido)-4-methylpentanamido)-5-guanidinopentanamide
- CBNumber:
- CB33160003
- Molecular Formula:
- C39H62N10O15
- Molecular Weight:
- 910.97
- MDL Number:
- MFCD32878249
- MOL File:
- 220334-14-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 1469.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.409±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| pka | 4.44±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Sequence | Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2 |
| FDA UNII | KM64V5W7RA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Volixibat potassium price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CRB1001535 | A6 peptide | 0.5mg | $165.73 | 2026-06-04 | Buy | |
| Biosynth | CRB1001535 | A6 peptide | 1mg | $226.78 | 2026-06-04 | Buy | |
| ChemScene | CS-0114007 | Angstrom6 99.98% | 220334-14-5 | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0114007 | Angstrom6 99.98% | 220334-14-5 | 10mg | $271 | 2026-06-04 | Buy |
| aablocks | AA01V7A1 | Angstrom6 | 220334-14-5 | 1mg | $60 | 2026-05-31 | Buy |
Volixibat potassium Chemical Properties, Uses, Production
Uses
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].
in vivo
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%[3].
| Animal Model: | C57Bl/6 mice (bearing B16-F10 cells)[3] |
| Dosage: | 100 mg/kg |
| Administration: | S.c.; twice a day for 11 days |
| Result: | Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control. |
References
[1] Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94. DOI:10.1016/j.ygyno.2008.06.028
[2] Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30. DOI:10.3389/fimmu.2015.00135
[3] Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10(11):2072-2082. DOI:10.1158/1535-7163.MCT-11-0351
Volixibat potassium Preparation Products And Raw materials
Raw materials
Preparation Products
Volixibat potassium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4726 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2436 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
| Hubei Weideli Chemical Reagent Co., Ltd. | 15871722230 | 15871722230@163.com | China | 4442 | 58 |
