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ASP5878

ASP5878 Structure
ASP5878 structure
CAS No.
1453208-66-6
Chemical Name:
ASP5878
Synonyms
ASP5878;ASP-5878 (ASP5878;ASP5878, 10 mM in DMSO;ASP5878; ASP 5878; ASP-5878;ASP 5878,Inhibitor,FGFR,ASP5878,Fibroblast growth factor receptor,inhibit;1H-Pyrazole-1-ethanol, 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-;2-(4-((5-((2,6-Difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol
CBNumber:
CB33164874
Molecular Formula:
C18H19F2N5O4
Molecular Weight:
407.37
MDL Number:
MOL File:
1453208-66-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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ASP5878 Properties

Boiling point 645.3±65.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 250 mg/mL (613.69 mM);Water : < 0.1 mg/mL (insoluble)
pka 14.41±0.10(Predicted)
form Solid
color Light yellow to yellow
FDA UNII C0Z095LL72

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

ASP5878 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 41841 ASP5878 ≥98% 1453208-66-6 1mg $43 2026-04-30 Buy
Cayman Chemical 41841 ASP5878 ≥98% 1453208-66-6 5mg $172 2026-04-30 Buy
Cayman Chemical 41841 ASP5878 ≥98% 1453208-66-6 10mg $280 2026-04-30 Buy
Cayman Chemical 41841 ASP5878 ≥98% 1453208-66-6 25mg $537 2026-04-30 Buy
Biosynth BA166836 ASP 5878 1453208-66-6 5mg $9528.75 2026-06-04 Buy
Product number Packaging Price Buy
41841 1mg $43 Buy
41841 5mg $172 Buy
41841 10mg $280 Buy
41841 25mg $537 Buy
BA166836 5mg $9528.75 Buy

ASP5878 Chemical Properties, Uses, Production

Uses

ASP5878 is a selective inhibitor of FGFR1, 2, 3 and 4.

in vivo

ASP5878 (3 mg/kg, orally, once daily) shows antitumor activity in a Hep3B2.1-7 subcutaneous xenograft and HCC orthotopic xenograft mouse model[1].
ASP5878 induces shrinkage of FGF19-expressing HCC xenograft model[1].

Animal Model:Four-week-old male nude mice (CAnN.Cg-Foxn1nu/CrlCrlj [nu/nu]) (Hep3B2.1-7 cells inoculated subcutaneously)[1].
Dosage:3 mg/kg.
Administration:Orally once daily from days 14 to 52.
Result:Induced tumor regression by 9% and 88% at 1 and 3 mg/kg, respectively, without affecting the body weight for 14 days.
Induced the suppression of FGFR4 phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation.
Animal Model:HCC orthotopic xenograft model (mouse)[1].
Dosage:3 mg/kg.
Administration:Orally once daily for 24 days.
Result:Exhibited a lower tumor burden than vehicle- and sorafenibtreated mice.
Induced sustained tumor regression without tumor regrowth.

IC 50

FGFR1: 0.47 nM (IC50); FGFR2: 0.6 nM (IC50); FGFR3: 0.74 nM (IC50); FGFR4: 3.5 nM (IC50)

ASP5878 Preparation Products And Raw materials

Raw materials

Preparation Products

ASP5878 Suppliers

Global Suppliers ( 56)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai JiYi Biotechnology Co. Ltd. 13621943973 sales@shjiyipharmatech.com China 1166 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai JiYi Biotechnology Co. Ltd. 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Amadis Chemical Company Limited 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
InvivoChem 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58

View Latest Price from ASP5878 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ASP5878 pictures 2026-07-27 ASP5878
1453208-66-6
 $60.00-247.00 99.89% 10g TargetMol Chemicals Inc.
  • ASP5878 pictures
  • ASP5878
    1453208-66-6
  • $60.00-247.00
  • 99.89%
  • TargetMol Chemicals Inc.

ASP5878 Spectrum

ASP5878(1453208-66-6)1HNMR

1453208-66-6 (ASP5878) Related Search:

FIIN-2 FIIN-3 DCC-3014 PD0166285 PD 173074
FGFR-1 alpha (iiic) protein, human (biotinylated, HEK293, His-AVI)

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ASP5878 ASP-5878 (ASP5878 ASP5878; ASP 5878; ASP-5878 ASP 5878,Inhibitor,FGFR,ASP5878,Fibroblast growth factor receptor,inhibit 1H-Pyrazole-1-ethanol, 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]- 2-(4-((5-((2,6-Difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol ASP5878, 10 mM in DMSO 1453208-66-6