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5-Hydroxy-2-nitrobenzaldehyde

5-Hydroxy-2-nitrobenzaldehyde structure

CAS No.: 42454-06-8

Chemical Name:: 5-Hydroxy-2-nitrobenzaldehyde

Synonyms: 3-Formyl-4-nitrophenol;LABOTEST-BB LT00233113;5-Hydroxy-2-nitrobenzaL;2-NITRO-5-HYDROXYBENZALDE;5-Hydroxy-2-nitrobenzaldehy;3-HYDROXY-6-NITROBENZALDEHYDE;5-HYDROXY-2-NITROBENZALDEHYDE;6-NITRO-3-HYDROXY BENZALDHYDE;6-NITRO-3-HYDROXYBENZALDEHYDE;2-NITRO-5-HYDROXYBENZALDEHYDE

CBNumber:: CB3318890

Molecular Formula:: C7H5NO4

Molecular Weight:: 167.12

MDL Number:: MFCD00007332

MOL File:: 42454-06-8.mol

MSDS File:: SDS

Last updated:2026-01-13 11:19:48

Product description	Number	Pack Size	Price
5-Hydroxy-2-nitrobenzaldehyde 98%	H48107	5g	$108.3
5-Hydroxy-2-nitrobenzaldehyde 98%	H48107	25g	$149.15
5-Hydroxy-2-nitrobenzaldehyde >98.0%(GC)(T)	H1039	5g	$113
5-Hydroxy-2-nitrobenzaldehyde >98.0%(GC)(T)	H1039	25g	$352
5-Hydroxy-2-nitrobenzaldehyde	H941005	10g	$130
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5-Hydroxy-2-nitrobenzaldehyde Properties

Melting point	165-169 °C (lit.)
Boiling point	373.0±32.0 °C(Predicted)
Density	1.500±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol.
pka	6.34±0.10(Predicted)
form	Solid
color	Pale Yellow to Yellow
Sensitive	Air Sensitive
BRN	1910196
Stability	Air Sensitive
InChI	1S/C7H5NO4/c9-4-5-3-6(10)1-2-7(5)8(11)12/h1-4,10H
InChIKey	XLYPHUGUKGMURE-UHFFFAOYSA-N
SMILES	[H]C(=O)c1cc(O)ccc1[N+]([O-])=O
CAS DataBase Reference	42454-06-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	VA926Z93IF
NIST Chemistry Reference	5-Hydroxy-2-nitro-benzaldehyde(42454-06-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

CU6700000

HS Code

29130000

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

5-Hydroxy-2-nitrobenzaldehyde price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H48107	5-Hydroxy-2-nitrobenzaldehyde 98%	42454-06-8	5g	$108.3	2025-07-31	Buy
Sigma-Aldrich	H48107	5-Hydroxy-2-nitrobenzaldehyde 98%	42454-06-8	25g	$149.15	2025-07-31	Buy
TCI Chemical	H1039	5-Hydroxy-2-nitrobenzaldehyde >98.0%(GC)(T)	42454-06-8	5g	$113	2025-07-31	Buy
TCI Chemical	H1039	5-Hydroxy-2-nitrobenzaldehyde >98.0%(GC)(T)	42454-06-8	25g	$352	2025-07-31	Buy
TRC	H941005	5-Hydroxy-2-nitrobenzaldehyde	42454-06-8	10g	$130	2021-12-16	Buy

Product number	Packaging	Price	Buy
H48107	5g	$108.3	Buy
H48107	25g	$149.15	Buy
H1039	5g	$113	Buy
H1039	25g	$352	Buy
H941005	10g	$130	Buy

5-Hydroxy-2-nitrobenzaldehyde Chemical Properties,Uses,Production

Chemical Properties

Yellow powder

Uses

5-Hydroxy-2-nitrobenzaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 409, 1979 DOI: 10.1021/jo01317a021

Synthesis

100-83-4

42454-06-8

The general procedure for the synthesis of 5-hydroxy-2-nitrobenzaldehyde (formula VI) using m-hydroxybenzaldehyde (formula V, R5=H) as starting material was as follows: 3 g of m-hydroxybenzaldehyde was slowly added to 30 ml of nitric acid (density = 1.17, 28% solution), and the temperature of the solution was maintained at a temperature between 35°C and 45°C during the reaction. After the addition was completed, hydrolysis was carried out and the reaction mixture was subsequently left to stand at room temperature. The reaction produced a yellow precipitate which was filtered and the precipitate was refluxed in 20 ml of benzene for 15 to 20 minutes. The insoluble material was separated and purified by recrystallization in water. 5-Hydroxy-2-nitrobenzaldehyde (formula VI) was finally obtained in 25% yield with a melting point of 167°C (molecular formula: C7H5NO4, molecular weight = 167).

References

[1] Helvetica Chimica Acta, 1992, vol. 75, # 4, p. 1185 - 1197
[2] Patent: US5139707, 1992, A
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 444 - 452
[4] Journal of the Chemical Society, 1925, vol. 127, p. 2171
[5] Journal of the Chemical Society, 1925, vol. 127, p. 876,877

5-Hydroxy-2-nitrobenzaldehyde Preparation Products And Raw materials

Raw materials

Ethanedioic acid, 1,2-bis(3-formylphenyl) ester Nitric acid Benzene 3-Hydroxy-4-nitrobenzaldehyde 3-Hydroxybenzaldehyde

Preparation Products

2-CHLORO-5-HYDROXYBENZALDEHYDE 5-Hydroxy-2-nitrobenzoic acid 5-Methoxy-2-nitrobenzaldehyde 6-Hydroxyquinoline-3-carboxylic acid ethyl ester Ethyl (3-formyl-4-nitrophenoxy)acetate

5-Hydroxybenzo[c]isoxazole 2-Phenyl-6-hydroxyquinoline 2-AMINO-5-HYDROXYBENZALDEHYDE

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5-Hydroxy-2-nitrobenzaldehyde Suppliers

Global( 238)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3982	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Baoji Guokang Healthchem co.,ltd	58
Hefei Hirisun Pharmatech Co., Ltd	58

View Lastest Price from 5-Hydroxy-2-nitrobenzaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-02	5-Hydroxy-2-nitrobenzaldehyde 42454-06-8	US $0.00-0.00 / KG	10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2026-01-30	5-Hydroxy-2-nitrobenzaldehyde 42454-06-8	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2019-08-08	5-Hydroxy-2-nitrobenzaldehyde 42454-06-8	US $1.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

5-Hydroxy-2-nitrobenzaldehyde
42454-06-8
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

5-Hydroxy-2-nitrobenzaldehyde
42454-06-8
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Hydroxy-2-nitrobenzaldehyde
42454-06-8
US $1.00 / KG
98%
Career Henan Chemical Co

5-Hydroxy-2-nitrobenzaldehyde Spectrum

5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)MS 5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)¹HNMR 5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)¹³CNMR 5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)IR1 5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)IR2 5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)Raman

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LABOTEST-BB LT00233113 2-NITRO-5-HYDROXYBENZALDEHYDE 6-NITRO-3-HYDROXYBENZALDEHYDE 6-NITRO-3-HYDROXY BENZALDHYDE 5-HYDROXY-2-NITROBENZALDEHYDE 3-HYDROXY-6-NITROBENZALDEHYDE 3-Formyl-4-nitrophenol 5-hydroxy-2-nitro-benzaldehyd Benzaldehyde, 5-hydroxy-2-nitro- 5-HYDROXY-2-NITROBENZALDEHYDE 98+% 2-NITRO-5-HYDROXYBENZALDE 5-Hydroxy-2-nitrobenzaldehy 2-Formyl-4-hydroxynitrobenzene, 3-Formyl-4-nitrophenol 5-Hydroxy-2-nitrobenzaldehyde 95+% 5-Hydroxy-2-nitrobenzaldehyde> 5-Hydroxy-2-nitrobenzaL 42454-06-8 HOC6H3NO2CHO ALDEHYDE Organic Building Blocks Aldehydes Carbonyl Compounds C7 Building Blocks Carbonyl Compounds Chemical Synthesis Organic Building Blocks Building Blocks Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde Aldehydes C7 Carbonyl Compounds