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5-Hydroxy-2-nitrobenzaldehyde

5-Hydroxy-2-nitrobenzaldehyde Structure
5-Hydroxy-2-nitrobenzaldehyde structure
CAS No.
42454-06-8
Chemical Name:
5-Hydroxy-2-nitrobenzaldehyde
Synonyms
3-Formyl-4-nitrophenol;LABOTEST-BB LT00233113;5-Hydroxy-2-nitrobenzaL;2-NITRO-5-HYDROXYBENZALDE;5-Hydroxy-2-nitrobenzaldehy;5-hydroxy-2-nitro-benzaldehyd;3-HYDROXY-6-NITROBENZALDEHYDE;5-HYDROXY-2-NITROBENZALDEHYDE;6-NITRO-3-HYDROXY BENZALDHYDE;6-NITRO-3-HYDROXYBENZALDEHYDE
CBNumber:
CB3318890
Molecular Formula:
C7H5NO4
Molecular Weight:
167.12
MDL Number:
MFCD00007332
MOL File:
42454-06-8.mol
MSDS File:
SDS
Last updated:2026-05-28 03:21:52
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5-Hydroxy-2-nitrobenzaldehyde Properties

Melting point 165-169 °C (lit.)
Boiling point 373.0±32.0 °C(Predicted)
Density 1.500±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in methanol.
pka 6.34±0.10(Predicted)
form Solid
color Pale Yellow to Yellow
Sensitive Air Sensitive
BRN 1910196
Stability Air Sensitive
InChI 1S/C7H5NO4/c9-4-5-3-6(10)1-2-7(5)8(11)12/h1-4,10H
InChIKey XLYPHUGUKGMURE-UHFFFAOYSA-N
SMILES [H]C(=O)c1cc(O)ccc1[N+]([O-])=O
CAS DataBase Reference 42454-06-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII VA926Z93IF
NIST Chemistry Reference 5-Hydroxy-2-nitro-benzaldehyde(42454-06-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  CU6700000
HS Code  29130000
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

5-Hydroxy-2-nitrobenzaldehyde price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H48107 5-Hydroxy-2-nitrobenzaldehyde 98% 42454-06-8 5g $122 2026-04-30 Buy
Sigma-Aldrich H48107 5-Hydroxy-2-nitrobenzaldehyde 98% 42454-06-8 25g $167 2026-04-30 Buy
TCI Chemical H1039 5-Hydroxy-2-nitrobenzaldehyde >98.0%(GC)(T) 42454-06-8 5g $96 2026-04-30 Buy
TCI Chemical H1039 5-Hydroxy-2-nitrobenzaldehyde >98.0%(GC)(T) 42454-06-8 25g $299 2026-04-30 Buy
TRC TRC-H941005-5G 5-Hydroxy-2-nitrobenzaldehyde 42454-06-8 5g $129 2026-06-03 Buy
Product number Packaging Price Buy
H48107 5g $122 Buy
H48107 25g $167 Buy
H1039 5g $96 Buy
H1039 25g $299 Buy
TRC-H941005-5G 5g $129 Buy

5-Hydroxy-2-nitrobenzaldehyde Chemical Properties, Uses, Production

Chemical Properties

Yellow powder

Uses

5-Hydroxy-2-nitrobenzaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 409, 1979 DOI: 10.1021/jo01317a021

Synthesis

3-Hydroxybenzaldehyde

100-83-4

5-Hydroxy-2-nitrobenzaldehyde

42454-06-8

The general procedure for the synthesis of 5-hydroxy-2-nitrobenzaldehyde (formula VI) using m-hydroxybenzaldehyde (formula V, R5=H) as starting material was as follows: 3 g of m-hydroxybenzaldehyde was slowly added to 30 ml of nitric acid (density = 1.17, 28% solution), and the temperature of the solution was maintained at a temperature between 35°C and 45°C during the reaction. After the addition was completed, hydrolysis was carried out and the reaction mixture was subsequently left to stand at room temperature. The reaction produced a yellow precipitate which was filtered and the precipitate was refluxed in 20 ml of benzene for 15 to 20 minutes. The insoluble material was separated and purified by recrystallization in water. 5-Hydroxy-2-nitrobenzaldehyde (formula VI) was finally obtained in 25% yield with a melting point of 167°C (molecular formula: C7H5NO4, molecular weight = 167).

References

[1] Helvetica Chimica Acta, 1992, vol. 75, # 4, p. 1185 - 1197
[2] Patent: US5139707, 1992, A
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 444 - 452
[4] Journal of the Chemical Society, 1925, vol. 127, p. 2171
[5] Journal of the Chemical Society, 1925, vol. 127, p. 876,877

5-Hydroxy-2-nitrobenzaldehyde Preparation Products And Raw materials

Raw materials

Ethanedioic acid, 1,2-bis(3-formylphenyl) ester Nitric acid Benzene 3-Hydroxy-4-nitrobenzaldehyde 3-Hydroxybenzaldehyde

Preparation Products

2-Chloro-5-hydroxybenzaldehyde 5-Hydroxy-2-nitrobenzoic acid 5-Methoxy-2-nitrobenzaldehyde 6-Hydroxyquinoline-3-carboxylic acid ethyl ester Ethyl (3-formyl-4-nitrophenoxy)acetate
5-Hydroxybenzo[c]isoxazole 2-Phenyl-6-hydroxyquinoline 2-Amino-5-hydroxybenzaldehyde

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5-Hydroxy-2-nitrobenzaldehyde Suppliers

Global Suppliers ( 240)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing dtftchem Technology Co., Ltd. 010-60275820 13031183356 elainezt@sina.com China 1386 62
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing dtftchem Technology Co., Ltd. 62
Energy Chemical 61
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 5-Hydroxy-2-nitrobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Hydroxy-2-nitrobenzaldehyde pictures 2026-03-20 5-Hydroxy-2-nitrobenzaldehyde
42454-06-8
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
5-Hydroxy-2-nitrobenzaldehyde pictures 2026-02-02 5-Hydroxy-2-nitrobenzaldehyde
42454-06-8
 10mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
5-Hydroxy-2-nitrobenzaldehyde pictures 2019-08-08 5-Hydroxy-2-nitrobenzaldehyde
42454-06-8
 $1.00 1KG 98% 100KG Career Henan Chemical Co

5-Hydroxy-2-nitrobenzaldehyde Spectrum

5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)MS5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)1HNMR5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)13CNMR5-Hydroxy-2-nitrobenzaldehyde(42454-06-8)IR15-Hydroxy-2-nitrobenzaldehyde(42454-06-8)IR25-Hydroxy-2-nitrobenzaldehyde(42454-06-8)Raman

42454-06-8 (5-Hydroxy-2-nitrobenzaldehyde) Related Search:

Salicylaldehyde 4-Nitrobenzaldehyde 2-Nitrobenzaldehyde 4-Hydroxybenzaldehyde 3-Hydroxybenzaldehyde
Chlorophosphonazo III 1,8-Dihydroxy-4,5-dinitroanthraquinone D-ribo-Hexanoic acid, 3-deoxy-, γ-lactone 6-Nitroveratraldehyde Methyl 2-nitro-3,4,5-trimethoxybenzoate
5-Hydroxy-2-nitrobenzoic acid Bifenox Methyl 4,5-dimethoxy-2-nitrobenzoate 4-Hydroxy-3-nitrobenzaldehyde Ethyl 4,5-dimethoxy-2-nitrobenzoate
6-Nitropiperonal 1,5-Dihydroxy-4,8-dinitroanthraquinone 4,5-Methylenedioxy-2-nitroacetophenone

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LABOTEST-BB LT00233113 2-NITRO-5-HYDROXYBENZALDEHYDE 6-NITRO-3-HYDROXYBENZALDEHYDE 6-NITRO-3-HYDROXY BENZALDHYDE 5-HYDROXY-2-NITROBENZALDEHYDE 3-HYDROXY-6-NITROBENZALDEHYDE 5-hydroxy-2-nitro-benzaldehyd Benzaldehyde, 5-hydroxy-2-nitro- 5-HYDROXY-2-NITROBENZALDEHYDE 98+% 2-NITRO-5-HYDROXYBENZALDE 5-Hydroxy-2-nitrobenzaldehy 2-Formyl-4-hydroxynitrobenzene, 3-Formyl-4-nitrophenol 5-Hydroxy-2-nitrobenzaldehyde 95+% 5-Hydroxy-2-nitrobenzaldehyde> 5-Hydroxy-2-nitrobenzaL 3-Formyl-4-nitrophenol 42454-06-8 HOC6H3NO2CHO ALDEHYDE Organic Building Blocks Aldehydes Carbonyl Compounds C7 Building Blocks Carbonyl Compounds Chemical Synthesis Organic Building Blocks Building Blocks Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde Aldehydes C7 Carbonyl Compounds