Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Chloro-5-hydroxybenzaldehyde

2-Chloro-5-hydroxybenzaldehyde

2-Chloro-5-hydroxybenzaldehyde Structure
2-Chloro-5-hydroxybenzaldehyde structure
CAS No.
7310-94-3
Chemical Name:
2-Chloro-5-hydroxybenzaldehyde
Synonyms
2-Chloro-5-hydroxybenzaldehyde;Benzaldehyde, 2-chloro-5-hydroxy-
CBNumber:
CB6487162
Molecular Formula:
C7H5ClO2
Molecular Weight:
156.57
MDL Number:
MFCD07783652
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-09-12 18:54:17
Request For Quotation

2-Chloro-5-hydroxybenzaldehyde Properties

Melting point 110.5-111.5 °C
Boiling point 272.4±20.0 °C(Predicted)
Density 1.404±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form crystalline powder
pka 8.80±0.18(Predicted)
color Faint yellow/faint orange

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P280-P301+P312-P304+P340
Hazard Codes  Xn
Risk Statements  22
HazardClass  IRRITANT
HS Code  2913000090

2-Chloro-5-hydroxybenzaldehyde price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FC67157 2-Chloro-5-hydroxybenzaldehyde 7310-94-3 1g $217.69 2026-06-04 Buy
Biosynth FC67157 2-Chloro-5-hydroxybenzaldehyde 7310-94-3 2g $290.24 2026-06-04 Buy
Biosynth FC67157 2-Chloro-5-hydroxybenzaldehyde 7310-94-3 5g $544.2 2026-06-04 Buy
Biosynth FC67157 2-Chloro-5-hydroxybenzaldehyde 7310-94-3 10g $997.8 2026-06-04 Buy
Biosynth FC67157 2-Chloro-5-hydroxybenzaldehyde 7310-94-3 25g $1632.5 2026-06-04 Buy
Product number Packaging Price Buy
FC67157 1g $217.69 Buy
FC67157 2g $290.24 Buy
FC67157 5g $544.2 Buy
FC67157 10g $997.8 Buy
FC67157 25g $1632.5 Buy

2-Chloro-5-hydroxybenzaldehyde Chemical Properties, Uses, Production

Uses

2-Chloro-5-hydroxybenzaldehyde is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine.

Synthesis

3-Hydroxybenzaldehyde

100-83-4

2-CHLORO-5-HYDROXYBENZALDEHYDE

7310-94-3

Benzaldehyde, 4-chloro-3-hydroxy-

56962-12-0

3-Hydroxybenzaldehyde (1 g, 10 mmol) was used as starting material and dissolved in acetonitrile (50 mL). To this solution, p-toluenesulfonic acid was added in batches at room temperature and after stirring for 5 minutes, N-chlorosuccinimide (NCS, 1.33 g, 10 mmol) was added. The reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction was quenched with aqueous sodium thiosulfate, followed by dilution with ethyl acetate and saturated saline. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (10:1 to 5:1) to afford 2-chloro-5-hydroxybenzaldehyde (Intermediate 28a, 340 mg, 21.7% yield) and 4-chloro-3-hydroxybenzaldehyde (Intermediate 28b, 310 mg, 19.7% yield) as yellow solids, respectively.The 1H NMR (CDCl3) data of 2-chloro-5-hydroxybenzaldehyde: δ10.43 (s, 1H), 7.54-7.56 (d, 1H), 7.30-7.37 (m, 2H). 1H-NMR (CDCl3) data of 4-chloro-3-hydroxybenzaldehyde: δ10.43 (s, 1H), 7.40 (d, 1H), 7.33 (d, 1H), 7.06- 7.09 (dd, 1H).

References

[1] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 391
[2] Patent: US2014/275528, 2014, A1. Location in patent: Paragraph 0322; 0323

2-Chloro-5-hydroxybenzaldehyde synthesis

876299-47-7
7310-94-3
Synthesis of 2-Chloro-5-hydroxybenzaldehyde from 4-chloro-3-(hydroxymethyl)phenol

2-Chloro-5-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

4-chloro-3-(hydroxymethyl)phenol 4-Chloro-3-methylphenol 2-Chloro-3-hydroxybenzaldehyde 97 Benzaldehyde, 4-chloro-3-hydroxy- 5-Hydroxy-2-nitrobenzaldehyde
3-Hydroxybenzaldehyde N-Chlorosuccinimide p-Toluenesulfonic acid monohydrate

1of2

Preparation Products

2-Chloro-5-hydroxybenzaldehyde Suppliers

Global Suppliers ( 78)
Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Xingui Biotechnology Co., Ltd. 15121041756 xingui2022@126.com China 9985 58
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Supplier Advantage
Shanghai Hanhong Scientific Co.,Ltd. 64
Hangzhou Sage Chemical Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
SynAsst Chemical. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
Bide Pharmatech Ltd. 60
Shanghai Xingui Biotechnology Co., Ltd. 58
Hangzhou J&H Chemical Co., Ltd. 59
Shanghai HuanChuan Industry Co.,Ltd. 50

View Latest Price from 2-Chloro-5-hydroxybenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-CHLORO-5-HYDROXYBENZALDEHYDE pictures 2020-01-05 2-CHLORO-5-HYDROXYBENZALDEHYDE
7310-94-3
 $1.00 1KG 99% 200kg Career Henan Chemical Co

2-Chloro-5-hydroxybenzaldehyde Spectrum

2-CHLORO-5-HYDROXYBENZALDEHYDE(7310-94-3)1HNMR2-CHLORO-5-HYDROXYBENZALDEHYDE(7310-94-3)13CNMR2-CHLORO-5-HYDROXYBENZALDEHYDE(7310-94-3)IR1

7310-94-3 (2-Chloro-5-hydroxybenzaldehyde) Related Search:

2-Chloro-5-hydroxybenzoic acid Methyl 2-chloro-5-hydroxybenzoate 2-Chloro-5-hydroxybenzonitrile 4-chloro-3-(hydroxymethyl)phenol 2-Chloro-3-hydroxybenzaldehyde 97
2,4-dichloro-5-hydroxyBenzaldehyde

1of2

Benzaldehyde, 2-chloro-5-hydroxy- 2-Chloro-5-hydroxybenzaldehyde 7310-94-3 Aromatic Aldehydes & Derivatives (substituted)