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TAMARIXETIN

CAS No.
603-61-2
Chemical Name:
TAMARIXETIN
Synonyms
Aids098167;amarixetin;Chiosmethin;TAMARIXETIN;Aids-098167;tamaraxetin;TAMARIEXETIN;4’-methylquercetin;4'-Methylquercetin;4’-methoxyquercetin
CBNumber:
CB3328499
Molecular Formula:
C16H12O7
Molecular Weight:
316.26
MDL Number:
MFCD00017308
MOL File:
603-61-2.mol
MSDS File:
SDS
Last updated:2026-02-27 15:07:11
Product description Number Pack Size Price
Tamarixetin phyproof? Reference Substance PHL85778 10MG $734
4'-O-methyl Quercetin ≥98% 22406 500μg $49
4'-O-methyl Quercetin ≥98% 22406 1mg $93
4'-O-methyl Quercetin ≥98% 22406 5mg $294
4'-O-methyl Quercetin ≥98% 22406 10mg $539
More product size

TAMARIXETIN Properties

Melting point 265-268°C
Boiling point 601.8±55.0 °C(Predicted)
Density 1.634±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: Slightly Soluble; Methanol: Slightly Soluble
pka 6.31±0.40(Predicted)
form A solid
color Yellow to brown
InChI 1S/C16H12O7/c1-22-11-3-2-7(4-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
InChIKey FPLMIPQZHHQWHN-UHFFFAOYSA-N
SMILES [o]1c2c([c](c(c1c3cc(c(cc3)OC)O)O)=O)c(cc(c2)O)O
LogP 2.420 (est)
FDA UNII 73WRA8Z8M8
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Risk Statements  22
Safety Statements  22-45
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

TAMARIXETIN price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL85778 Tamarixetin phyproof? Reference Substance 603-61-2 10MG $734 2025-07-31 Buy
Cayman Chemical 22406 4'-O-methyl Quercetin ≥98% 603-61-2 500μg $49 2024-03-01 Buy
Cayman Chemical 22406 4'-O-methyl Quercetin ≥98% 603-61-2 1mg $93 2024-03-01 Buy
Cayman Chemical 22406 4'-O-methyl Quercetin ≥98% 603-61-2 5mg $294 2024-03-01 Buy
Cayman Chemical 22406 4'-O-methyl Quercetin ≥98% 603-61-2 10mg $539 2024-03-01 Buy
Product number Packaging Price Buy
PHL85778 10MG $734 Buy
22406 500μg $49 Buy
22406 1mg $93 Buy
22406 5mg $294 Buy
22406 10mg $539 Buy

TAMARIXETIN Chemical Properties,Uses,Production

Description

4''-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4''-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4''-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4''-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).

Uses

A major metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Definition

ChEBI: A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

in vivo

Tamarixetin (0.2% feed management; 6 weeks) improves the myocardial hypertrophy model [2].
Tamarixetin (intraperitoneal injection; 1 mg/kg; single dose) has better anti-inflammatory properties, which is related to the increase of the immune cell population secreting IL-10 in mouse models of bacterial septicemia[3].

Animal Model:Transverse aortic constriction (TAC) mouse model[2]
Dosage:0.2%
Administration:Feed management; 6 weeks
Result:Alleviated pressureoverloadinduced cardiac hypertrophy in mice.
Attenuated cardiac fibrosis and apoptosis in pressureoverloaded hearts.
Suppressed oxidative stress.
Negatively regulated NFAT nuclear translocation level.
Was able to the down-regulate the activation of PI3K/AKT signaling pathway in the heart after pressure overload.

References

[1] FABIO NICOLINI. Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells.[J]. Molecular Carcinogenesis, 2014, 53 12: 939-950. DOI: 10.1002/mc.22055
[2] KEE W. TAN . Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)[J]. Food Chemistry, 2013, 138 4: Pages 2267-2274. DOI: 10.1016/j.foodchem.2012.12.021
[3] I C EZENYI. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum.[J]. Parasitology Research, 2014, 113 12: 4415-4422. DOI: 10.1007/s00436-014-4119-y

TAMARIXETIN Preparation Products And Raw materials

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29830 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+86-28-82633860; +8618080483897 sales@biopurify.com China 3751 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32469 58
Aktin Chemicals, Inc.
028-85159085 info@aktinchem.com CHINA 1025 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23541 58
Finetech Industry Limited
+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9629 58
Henan Alfa Chemical Co., Ltd
+8615838112936 sale03@alfachem.cn China 9252 58

View Lastest Price from TAMARIXETIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tamarixetin pictures 2026-02-27 Tamarixetin
603-61-2
US $83.00-289.00 / mg 98.52% 10g TargetMol Chemicals Inc.
Tamarixetin pictures 2023-02-24 Tamarixetin
603-61-2
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
TAMARIXETIN pictures 2019-07-06 TAMARIXETIN
603-61-2
US $1.00 / KG 1g 99% 100KG Career Henan Chemical Co
  • Tamarixetin pictures
  • Tamarixetin
    603-61-2
  • US $83.00-289.00 / mg
  • 98.52%
  • TargetMol Chemicals Inc.
  • Tamarixetin pictures
  • Tamarixetin
    603-61-2
  • US $0.00 / mg
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.
  • TAMARIXETIN pictures
  • TAMARIXETIN
    603-61-2
  • US $1.00 / KG
  • 99%
  • Career Henan Chemical Co

TAMARIXETIN Spectrum

3,3',5,7 TETRAHYDROXY-4'-METHOXYFLAVONE TAMARIXETIN QUERCETIN-4'-METHYL ETHER 3,3’,5,7-tetrahydroxy-4’-methoxy-flavon QUERCETIN-4''-METHYL ETHER hplc 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Chiosmethin 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)- Aids098167 Aids-098167 4'-METHOXY-3,3',5,7-TETRAHYDROXYFLAVONE 4'-METHOXY-3,5,7,3'-TETRAHYDROFLAVONE 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-on 4’-methoxy-3,3’,5,7-tetrahydroxy-flavon 4’-methoxyquercetin 4’-methylquercetin 4’-o-methylquercetin tamaraxetin 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one TAMARIEXETIN TAMARIXETIN WITH HPLC 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone amarixetin TamarixetinQ: What is Tamarixetin Q: What is the CAS Number of Tamarixetin Q: What is the storage condition of Tamarixetin Q: What are the applications of Tamarixetin Tamarixetin(3,3',5,7-Tetrahydroxy-4'-Methoxyflavone) 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one 3,3',5,7-Tetrahydroxy 4'-methoxyflavone 4'-Methylquercetin Quercetin 4'-methyl ether Tamarixetin, 10 mM in DMSO 4′-O-Methyl Quercetin, CAS 603-61-2 603-61-2 C16H12O7 Aromatics Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Flavanols