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TAMARIXETIN

TAMARIXETIN Structure
TAMARIXETIN structure
CAS No.
603-61-2
Chemical Name:
TAMARIXETIN
Synonyms
Aids098167;amarixetin;Chiosmethin;TAMARIXETIN;Aids-098167;tamaraxetin;TAMARIEXETIN;4’-methylquercetin;4'-Methylquercetin;4’-methoxyquercetin
CBNumber:
CB3328499
Molecular Formula:
C16H12O7
Molecular Weight:
316.26
MDL Number:
MFCD00017308
MOL File:
603-61-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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TAMARIXETIN Properties

Melting point 265-268°C
Boiling point 601.8±55.0 °C(Predicted)
Density 1.634±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: Slightly Soluble; Methanol: Slightly Soluble
form A solid
pka 6.31±0.40(Predicted)
color Yellow to brown
InChI 1S/C16H12O7/c1-22-11-3-2-7(4-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
InChIKey FPLMIPQZHHQWHN-UHFFFAOYSA-N
SMILES [o]1c2c([c](c(c1c3cc(c(cc3)OC)O)O)=O)c(cc(c2)O)O
LogP 2.420 (est)
FDA UNII 73WRA8Z8M8
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Risk Statements  22
Safety Statements  22-45
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

TAMARIXETIN price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL85778 Tamarixetin phyproof? Reference Substance 603-61-2 10MG $787 2026-04-30 Buy
Cayman Chemical 22406 4''-O-methyl Quercetin ≥95% 603-61-2 500μg $54 2026-04-30 Buy
Cayman Chemical 22406 4''-O-methyl Quercetin ≥95% 603-61-2 1mg $103 2026-04-30 Buy
Cayman Chemical 22406 4''-O-methyl Quercetin ≥95% 603-61-2 5mg $324 2026-04-30 Buy
Cayman Chemical 22406 4''-O-methyl Quercetin ≥95% 603-61-2 10mg $593 2026-04-30 Buy
Product number Packaging Price Buy
PHL85778 10MG $787 Buy
22406 500μg $54 Buy
22406 1mg $103 Buy
22406 5mg $324 Buy
22406 10mg $593 Buy

TAMARIXETIN Chemical Properties,Uses,Production

Description

4''-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4''-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4''-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4''-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).

Uses

A major metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Definition

ChEBI: A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

in vivo

Tamarixetin (0.2% feed management; 6 weeks) improves the myocardial hypertrophy model [2].
Tamarixetin (intraperitoneal injection; 1 mg/kg; single dose) has better anti-inflammatory properties, which is related to the increase of the immune cell population secreting IL-10 in mouse models of bacterial septicemia[3].

Animal Model:Transverse aortic constriction (TAC) mouse model[2]
Dosage:0.2%
Administration:Feed management; 6 weeks
Result:Alleviated pressureoverloadinduced cardiac hypertrophy in mice.
Attenuated cardiac fibrosis and apoptosis in pressureoverloaded hearts.
Suppressed oxidative stress.
Negatively regulated NFAT nuclear translocation level.
Was able to the down-regulate the activation of PI3K/AKT signaling pathway in the heart after pressure overload.

References

[1] FABIO NICOLINI. Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells.[J]. Molecular Carcinogenesis, 2014, 53 12: 939-950. DOI: 10.1002/mc.22055
[2] KEE W. TAN . Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)[J]. Food Chemistry, 2013, 138 4: Pages 2267-2274. DOI: 10.1016/j.foodchem.2012.12.021
[3] I C EZENYI. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum.[J]. Parasitology Research, 2014, 113 12: 4415-4422. DOI: 10.1007/s00436-014-4119-y

TAMARIXETIN Preparation Products And Raw materials

Raw materials

2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4-benzopyrone 4',7-Dimethoxy-3,3',5-trihydroxyflavone AYANIN Rhamnetin Quercetin
Dimethyl sulfate Rutin

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Preparation Products

TAMARIXETIN Suppliers

Global( 154)Suppliers
Supplier Tel Email Country ProdList Advantage
SiChuan HHTC Biological Technology Co., LTD 15982498737 18380486776 12787973@qq.com China 448 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
Chengdu Biopurify Phytochemicals Ltd. +86-028-82633397 18982077548 cwb1@biopurify.cn China 2376 60
Shanghai Winherb Medical Technology Co., Ltd. 17301719108 13341702378 winherb@126.com China 1245 58
Shanghai Tauto Biotech Co., Ltd. 021-51320588 tauto@tautobiotech.com China 3984 66
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Supplier Advantage
SiChuan HHTC Biological Technology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Chembest Research Laboratories Limited 61
Chemsky (shanghai) International Co.,Ltd 60
BioBioPha Co., Ltd. 65
Chengdu Biopurify Phytochemicals Ltd. 60
Shanghai Winherb Medical Technology Co., Ltd. 58
Shanghai Tauto Biotech Co., Ltd. 66
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58

View Lastest Price from TAMARIXETIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tamarixetin pictures 2026-07-27 Tamarixetin
603-61-2
 $83.00-289.00 98.76% 10g TargetMol Chemicals Inc.
Tamarixetin pictures 2023-02-24 Tamarixetin
603-61-2
 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
TAMARIXETIN pictures 2019-07-06 TAMARIXETIN
603-61-2
 $1.00 1g 99% 100KG Career Henan Chemical Co
  • Tamarixetin pictures
  • Tamarixetin
    603-61-2
  • $83.00-289.00
  • 98.76%
  • TargetMol Chemicals Inc.
  • Tamarixetin pictures
  • Tamarixetin
    603-61-2
  • $0.00
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.

TAMARIXETIN Spectrum

TAMARIXETIN(603-61-2)1HNMR

603-61-2(TAMARIXETIN)Related Search:

SPIRAEOSIDE ARTEMETIN CASTICIN TAMARIXETIN Quercetin-3,7,3',4'-tetramethyl ether
3,4'-Dimethoxy-3',5,7-trihydroxyflavone 3,7,3',4'-Tetramethylgossypetin Fisetin 3,5,7-Trihydroxy-3',4',5'-trimethoxyflavone Quercetin-3,5,7,3',4'-pentamethyl ether
4'-Methoxyflavone 3,3',4',5,6,7,8-heptamethoxyflavone 4',7-Dimethoxy-3,3',5-trihydroxyflavone QUERCETIN-7,4'-DIGLUCOSIDE QUERCETINPENTAACETATE
Ombuoside 3'-Benzyloxy-5,7-dihydroxy-3,4'-dimethoxyflavone 3,4-Dimethoxy-3,5,7-trihydroxyflavone

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3,3',5,7 TETRAHYDROXY-4'-METHOXYFLAVONE TAMARIXETIN QUERCETIN-4'-METHYL ETHER 3,3’,5,7-tetrahydroxy-4’-methoxy-flavon QUERCETIN-4''-METHYL ETHER hplc 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Chiosmethin 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)- Aids098167 Aids-098167 4'-METHOXY-3,3',5,7-TETRAHYDROXYFLAVONE 4'-METHOXY-3,5,7,3'-TETRAHYDROFLAVONE 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-on 4’-methoxy-3,3’,5,7-tetrahydroxy-flavon 4’-methoxyquercetin 4’-methylquercetin 4’-o-methylquercetin tamaraxetin 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one TAMARIEXETIN TAMARIXETIN WITH HPLC 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone amarixetin TamarixetinQ: What is Tamarixetin Q: What is the CAS Number of Tamarixetin Q: What is the storage condition of Tamarixetin Q: What are the applications of Tamarixetin Tamarixetin（3,3',5,7-Tetrahydroxy-4'-Methoxyflavone） 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one 3,3',5,7-Tetrahydroxy 4'-methoxyflavone 4'-Methylquercetin Quercetin 4'-methyl ether Tamarixetin, 10 mM in DMSO 4′-O-Methyl Quercetin, CAS 603-61-2 603-61-2 C16H12O7 Aromatics Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Flavanols