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1-Boc-4-(4-amino-phenoxy)-piperidine

1-Boc-4-(4-amino-phenoxy)-piperidine Structure
1-Boc-4-(4-amino-phenoxy)-piperidine structure
CAS No.
138227-63-1
Chemical Name:
1-Boc-4-(4-amino-phenoxy)-piperidine
Synonyms
tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate;4-[(1-Boc-4-piperidyl)oxy]aniline;Boc-4-(4-amino-phenoxy)piperidine;N-Boc-4-(4-aminophenoxy)piperidine;1-Boc-4-(4-amino-phenoxy)-piperidine;1N-BOC 4-(4'-AMINOPHENOXY) PIPERIDINE;4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline;tert-Butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate;1-N-Boc-4-(4-aminophenoxy)piperidine, CAS 138227-63-1;4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline 98%
CBNumber:
CB3330113
Molecular Formula:
C16H24N2O3
Molecular Weight:
292.37
MDL Number:
MFCD04115023
MOL File:
138227-63-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:59
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1-Boc-4-(4-amino-phenoxy)-piperidine Properties

Melting point 80-81 °C
Boiling point 430.3±35.0 °C(Predicted)
Density 1.140±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 5.11±0.10(Predicted)
Appearance Brown to dark brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  T
Risk Statements  25
Safety Statements  45
HS Code  2921490090

1-Boc-4-(4-amino-phenoxy)-piperidine price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 265789 1-Boc-4-(4-aminophenoxy)piperidine Asreported 138227-63-1 250mg $368 2026-06-03 Buy
Usbiological 265789 1-Boc-4-(4-aminophenoxy)piperidine Asreported 138227-63-1 500mg $509 2026-06-03 Buy
Usbiological 265789 1-Boc-4-(4-aminophenoxy)piperidine Asreported 138227-63-1 1g $834 2026-06-03 Buy
Usbiological 265789 1-Boc-4-(4-aminophenoxy)piperidine Asreported 138227-63-1 2g $1171 2026-06-03 Buy
Usbiological 265789 1-Boc-4-(4-aminophenoxy)piperidine Asreported 138227-63-1 5g $1669 2026-06-03 Buy
Product number Packaging Price Buy
265789 250mg $368 Buy
265789 500mg $509 Buy
265789 1g $834 Buy
265789 2g $1171 Buy
265789 5g $1669 Buy

1-Boc-4-(4-amino-phenoxy)-piperidine Chemical Properties,Uses,Production

Synthesis

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

138227-62-0

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

138227-63-1

The general procedure for the synthesis of 1-Boc-4-(4-aminophenoxy)piperidine from tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate was as follows: 4-(1-tert-butoxycarbonylpiperidin-4-yloxy)nitrobenzene (11.9 g) obtained in Reference Example 105 was dissolved in methanol (100 mL) and palladium-carbon catalyst (1.9 g) was added. The reaction mixture was stirred at room temperature for 4 hours in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate in the ratio of 1:1, v/v. The final product was 1-Boc-4-(4-aminophenoxy)piperidine (10.7 g, 99% yield) as a light red solid.1H NMR (400 MHz, CDCl3) δ ppm: 1.46 (9H, s), 1.71 (2H, m). 1.87 (2H, m), 3.27 (2H, m), 3.71 (2H, m), 4.26 (1H, m), 6.63 (2H, d, J = 8.5 Hz), 6.76 (2H, d, J = 8.5 Hz).

References

[1] Chemical and Pharmaceutical Bulletin, 2008, vol. 56, # 6, p. 758 - 770
[2] Patent: EP1375482, 2004, A1. Location in patent: Page 159
[3] Bioorganic and medicinal chemistry, 2002, vol. 10, # 5, p. 1509 - 1523
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 1 - 7
[5] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 205; 206

1-Boc-4-(4-amino-phenoxy)-piperidine synthesis

138227-62-0
138227-63-1
Synthesis of 1-Boc-4-(4-amino-phenoxy)-piperidine from tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

1-Boc-4-(4-amino-phenoxy)-piperidine Preparation Products And Raw materials

Raw materials

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate Hydrogen Methanol Ethyl acetate

Preparation Products

1-Boc-4-(4-amino-phenoxy)-piperidine Suppliers

Global( 88)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Huaxing Research Technology Co., Ltd. 13263398295 15563557098 2885733844@qq.com China 84 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 025-58196018 800028039 sales@fartop.net China 2227 55
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Supplier Advantage
Beijing Huaxing Research Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Energy Chemical 61
Pure Chemistry Scientific Inc. 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 55
Nanjing Norris-Pharm Technology Co., Ltd 55
9ding chemical ( Shanghai) Limited 56

1-Boc-4-(4-amino-phenoxy)-piperidine Spectrum

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE(138227-63-1)1HNMR

138227-63-1(1-Boc-4-(4-amino-phenoxy)-piperidine)Related Search:

1-N-Boc-4-(4-amino-2-methylphenoxy)piperidine 6-Acetylamino-4-oxo-2-spiro(N-Boc-piperidine-4-yl)-benzopyran 1-Boc-4-(4-amino-phenoxy)-piperidine 6-Acetylamino-2-spiro(N-Boc-piperidine-4-yl)-benzopyran 1N-Boc 4-(2'-methyl-4'-nitrophenoxy) piperidine
tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

1of2

4-(4-AMINO-PHENOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1N-BOC 4-(4'-AMINOPHENOXY) PIPERIDINE Boc-4-(4-amino-phenoxy)piperidine tert-Butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate tert-Butyl 4-(4-aminophenoxy)tetrahydro-1(2H)-pyridinecarboxylate 4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline 1-Piperidinecarboxylic acid, 4-(4-aMinophenoxy)-, 1,1-diMethylethyl ester N-Boc-4-(4-aminophenoxy)piperidine 4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline 98% 4-(4-aminophenoxy)-1-piperidinecarboxylic acid tert-butyl ester 4-[(1-Boc-4-piperidyl)oxy]aniline 1-N-Boc-4-(4-aminophenoxy)piperidine, CAS 138227-63-1 tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate 1-Boc-4-(4-amino-phenoxy)-piperidine 138227-63-1 pharmacetical