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1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE structure

CAS No.: 138227-63-1

Chemical Name:: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

Synonyms: Boc-4-(4-amino-phenoxy)piperidine;4-[(1-Boc-4-piperidyl)oxy]aniline;N-Boc-4-(4-aminophenoxy)piperidine;1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE;1N-BOC 4-(4'-AMINOPHENOXY) PIPERIDINE;tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate;4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline;tert-Butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate;1-N-Boc-4-(4-aminophenoxy)piperidine, CAS 138227-63-1;4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline 98%

CBNumber:: CB3330113

Molecular Formula:: C16H24N2O3

Molecular Weight:: 292.37

MDL Number:: MFCD04115023

MOL File:: 138227-63-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:42

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1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Properties

Boiling point	430.3±35.0 °C(Predicted)
Density	1.140±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	5.11±0.10(Predicted)
Appearance	Brown to dark brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
Hazard Codes	T
Risk Statements	25
Safety Statements	45
HS Code	2921490090

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B809788	tert-Butyl4-(4-Aminophenoxy)piperidine-1-carboxylate	138227-63-1	50mg	$45	2021-12-16	Buy
AK Scientific	J54765	1-Boc-4-(4-aminophenoxy)piperidine	138227-63-1	250mg	$49	2021-12-16	Buy
Biosynth Carbosynth	FB51390	1-Boc-4-(4-aminophenoxy)piperidine	138227-63-1	250mg	$85	2021-12-16	Buy
AK Scientific	W3012	1-Boc-4-(4-aminophenoxy)piperidine	138227-63-1	1g	$114	2021-12-16	Buy
Biosynth Carbosynth	FB51390	1-Boc-4-(4-aminophenoxy)piperidine	138227-63-1	500mg	$135	2021-12-16	Buy

Product number	Packaging	Price	Buy
B809788	50mg	$45	Buy
J54765	250mg	$49	Buy
FB51390	250mg	$85	Buy
W3012	1g	$114	Buy
FB51390	500mg	$135	Buy

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Chemical Properties,Uses,Production

Synthesis

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

138227-62-0

138227-63-1

The general procedure for the synthesis of 1-Boc-4-(4-aminophenoxy)piperidine from tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate was as follows: 4-(1-tert-butoxycarbonylpiperidin-4-yloxy)nitrobenzene (11.9 g) obtained in Reference Example 105 was dissolved in methanol (100 mL) and palladium-carbon catalyst (1.9 g) was added. The reaction mixture was stirred at room temperature for 4 hours in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate in the ratio of 1:1, v/v. The final product was 1-Boc-4-(4-aminophenoxy)piperidine (10.7 g, 99% yield) as a light red solid.1H NMR (400 MHz, CDCl3) δ ppm: 1.46 (9H, s), 1.71 (2H, m). 1.87 (2H, m), 3.27 (2H, m), 3.71 (2H, m), 4.26 (1H, m), 6.63 (2H, d, J = 8.5 Hz), 6.76 (2H, d, J = 8.5 Hz).

References

[1] Chemical and Pharmaceutical Bulletin, 2008, vol. 56, # 6, p. 758 - 770
[2] Patent: EP1375482, 2004, A1. Location in patent: Page 159
[3] Bioorganic and medicinal chemistry, 2002, vol. 10, # 5, p. 1509 - 1523
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 1 - 7
[5] Patent: WO2015/92431, 2015, A1. Location in patent: Page/Page column 205; 206

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE synthesis

Synthesis of 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE from tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Preparation Products And Raw materials

Raw materials

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate Hydrogen Methanol Ethyl acetate

Preparation Products

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49979	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	10997	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58

Supplier	Advantage
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Spectrum

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE(138227-63-1)¹HNMR

138227-63-1(1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE)Related Search:

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1N-BOC 4-(2'-METHYL-4'-NITROPHENOXY) PIPERIDINE

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4-(4-AMINO-PHENOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1N-BOC 4-(4'-AMINOPHENOXY) PIPERIDINE 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE Boc-4-(4-amino-phenoxy)piperidine tert-Butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate tert-Butyl 4-(4-aminophenoxy)tetrahydro-1(2H)-pyridinecarboxylate 4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-(4-aMinophenoxy)-, 1,1-diMethylethyl ester N-Boc-4-(4-aminophenoxy)piperidine 4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline 98% 4-(4-aminophenoxy)-1-piperidinecarboxylic acid tert-butyl ester 4-[(1-Boc-4-piperidyl)oxy]aniline 1-N-Boc-4-(4-aminophenoxy)piperidine, CAS 138227-63-1 138227-63-1 pharmacetical