G-TPP
- CAS No.
- 1131626-46-4
- Chemical Name:
- G-TPP
- Synonyms
- Gamitrinib;G-TPP;Gamitrinib TPP;17-Demethoxy-17-[[6-(triphenylphosphonio)hexyl]amino]geldanamycin (ACI)
- CBNumber:
- CB33303044
- Molecular Formula:
- C52H65N3O8P+
- Molecular Weight:
- 891.08
- MDL Number:
- MFCD30527509
- MOL File:
- 1131626-46-4.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| FDA UNII | M6LC47TUG3 |
| NCI Drug Dictionary | gamitrinib |
G-TPP price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GVB62646 | Gamitrinib | 1131626-46-4 | 2mg | $1280.74 | 2026-06-04 | Buy |
| Biosynth | GVB62646 | Gamitrinib | 1131626-46-4 | 5mg | $1784.75 | 2026-06-04 | Buy |
| Biosynth | GVB62646 | Gamitrinib | 1131626-46-4 | 10mg | $2855.6 | 2026-06-04 | Buy |
| Biosynth | GVB62646 | Gamitrinib | 1131626-46-4 | 25mg | $6425 | 2026-06-04 | Buy |
G-TPP Chemical Properties, Uses, Production
Uses
Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
in vivo
Interestingly, 2 cycles of intracranial TRAIL combined with systemic G-TPP suppress the growth of established glioblastomas, with no significant animal weight loss throughout treatment. Analysis of brain sections from these mice, but not single agent-treated animals, show loss of tumor cell proliferation, internucleosomal DNA fragmentation, and caspase-3 activity, consistent with extensive activation of apoptosis in vivo[1].
IC 50
HSP90
References
[1] Markus D. Siegelin, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011 Apr 1; 121(4): 1349–1360. DOI:10.1172/JCI44855
G-TPP Preparation Products And Raw materials
Raw materials
Preparation Products
G-TPP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| Guangdong Wengjiang Chemical Reagent Co.,Ltd. | 0751-2815983 13927872582 | 3008325437@qq.com | China | 9890 | 58 |
| Shaoguan Xinrunhe Biotechnology Co., Ltd. | 19022763608 19022763608 | 3873625718@qq.com | China | 1961 | 58 |
| Qingdao Haizhi Weiyuan Biotechnology Co., Ltd. | 18317699790 18317699790 | l202008112023@163.com | China | 7733 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16504 | 58 |
