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Ganetespib

Ganetespib Structure
Ganetespib structure
CAS No.
888216-25-9
Chemical Name:
Ganetespib
Synonyms
STA-9090;CS-654;SAT9090;Ganetespib;STA-9090;STA9090;Ganetespib, >=98%;STA-9090/Ganetespib;Ganetespib USP/EP/BP;Ganetespib (STA-9090);Ganetespib, 10 mM in DMSO
CBNumber:
CB02566762
Molecular Formula:
C20H20N4O3
Molecular Weight:
364.4
MDL Number:
MFCD22420818
MOL File:
888216-25-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:25:08
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Ganetespib Properties

Density 1.39
storage temp. -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form solid
pka 7.38±0.20(Predicted)
color White
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)
InChIKey RVAQIUULWULRNW-UHFFFAOYSA-N
SMILES N1=C(C2=CC(C(C)C)=C(O)C=C2O)N(C2C=CC3=C(C=2)C=CN3C)C(=O)N1
FDA UNII 2E8412Y946
NCI Dictionary of Cancer Terms ganetespib
NCI Drug Dictionary ganetespib

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P280
HS Code  2933998090

Ganetespib price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19432 Ganetespib ≥98% 888216-25-9 1mg $49 2021-12-16 Buy
Cayman Chemical 19432 Ganetespib ≥98% 888216-25-9 5mg $196 2021-12-16 Buy
Biosynth FG137675 Ganetespib 888216-25-9 0.05g $194.7 2026-06-04 Buy
Biosynth FG137675 Ganetespib 888216-25-9 0.1g $363.44 2026-06-04 Buy
Biosynth FG137675 Ganetespib 888216-25-9 0.25g $843.7 2026-06-04 Buy
Product number Packaging Price Buy
19432 1mg $49 Buy
19432 5mg $196 Buy
FG137675 0.05g $194.7 Buy
FG137675 0.1g $363.44 Buy
FG137675 0.25g $843.7 Buy

Ganetespib Chemical Properties, Uses, Production

Description

Ganetespib, also known as STA-9090, is a unique resorcinolic triazolone inhibitor of Hsp90, which is currently in clinical trials for a number of human cancers. It has shown promise in preclinical tests against various cancers, including lung cancer, prostate cancer, and leukemia. Moreover, It has also shown strong activity toward breast cancer, non-small cell lung cancer, gastric cancer, and acute myeloid leukemia.

Definition

ChEBI: Ganetespib is a member of triazoles and a ring assembly. It is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.

General Description

A synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition.

target

HSP90

References

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer DOI:10.1158/1078-0432.CCR-11-2967
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/ganetespib
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy DOI: 10.1158/1535-7163.MCT-11-0755
Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice doi: 10.3390/ijms24055014
A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies DOI:10.1186/1471-2407-13-152
Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner DOI:10.1038/cddis.2017.108

Ganetespib Preparation Products And Raw materials

Raw materials

Preparation Products

Ganetespib Suppliers

Global Suppliers ( 170)
Supplier Tel Email Country ProdList Advantage
Changzhou Yongfeng Biomedicine Co. Ltd. 15006117673 2973592490@qq.com China 270 58
Shanghai Fei Yan Chemical Technology Co., Ltd. 021-34663897 13816465839 1141976404@qq.com China 41 57
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 025-58196018 800028039 sales@fartop.net China 2227 55
Supplier Advantage
Changzhou Yongfeng Biomedicine Co. Ltd. 58
Shanghai Fei Yan Chemical Technology Co., Ltd. 57
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Jia Xing Isenchem Co.,Ltd 66
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Jinan Trio PharmaTech Co., Ltd. 62
BOC Sciences 65
Dalian Meilun Biotech Co., Ltd. 58
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 55

View Latest Price from Ganetespib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ganetespib pictures 2026-04-22 Ganetespib
888216-25-9
 $61.00-135.00 99.51% 10g TargetMol Chemicals Inc.
Ganetespib pictures 2021-07-13 Ganetespib
888216-25-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Ganetespib pictures 2021-07-09 Ganetespib
888216-25-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • Ganetespib pictures
  • Ganetespib
    888216-25-9
  • $61.00-135.00
  • 99.51%
  • TargetMol Chemicals Inc.
  • Ganetespib pictures
  • Ganetespib
    888216-25-9
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Ganetespib pictures
  • Ganetespib
    888216-25-9
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Ganetespib Spectrum

Ganetespib(888216-25-9)1HNMR

888216-25-9 (Ganetespib) Related Search:

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Luminespib

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5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganetespib (STA-9090) 3H-1,2,4-Triazol-3-one, 5-[2,4-dihydroxy-5-(1-Methylethyl)phenyl]-2,4-dihydro-4-(1-Methyl-1H-indol-5-yl)- SAT9090 2,4-Dihydro-5-[2,4-dihydroxy-5-isopropylphenyl]-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one 5-{1,5-Dihydro-3-[2,4-dihydroxy-5-(prop-2-yl)phenyl]-5-oxo-4H-1,2,4-triazol-4-yl}-1-methyl-1H-indole, 4-[4,5-Dihydro-4-(1-methyl-1H-indol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-6-(prop-2-yl)benzene-1,3-di ol 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one STA-9090/Ganetespib STA9090; STA 9090; STA-9090; GANETESPIB STA-9090; STA 9090; STA9090 CS-654 3-[2,4-Dihydroxy-5-(propan-2-yl)phenyl]-4-(1-methyl-1H-indol-5-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one Ganete ganetespib (Hsp90 inhibitor) 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-1H-1,2,4-triazol-5(4H)-one STA-9090;STA9090 GANETESPIB (STA-9090);STA-9090;STA 9090;STA9090 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-tria Ganetespib, >=98% Ganetespib 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4H-1,2,4-triazole Ganetespib USP/EP/BP (5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one Ganetespib, 10 mM in DMSO STA-9090 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one 888216-25-9 Inhibitors