iRGD
- CAS No.
- 1392278-76-0
- Chemical Name:
- iRGD
- Synonyms
- c(CRGDKGPDC);iRGD;iRGD TFA;iGRD peptide;H-CRGDKGPDC-OH;H-CRGDKGPDC-NH2;iGRD peptide acetate;iRGD peptide TFA salt;inhibit,Inhibitor,iRGD peptide,Integrin;L-Cysteine, L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-, cyclic (1→9)-disulfide
- CBNumber:
- CB33368577
- Molecular Formula:
- C35H57N13O14S2
- Molecular Weight:
- 948.04
- MDL Number:
- MOL File:
- 1392278-76-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| iRGD Peptide ≥95% | 42319 | 1mg | $28 |
| iRGD Peptide ≥95% | 42319 | 5mg | $125 |
| iRGD Peptide ≥95% | 42319 | 10mg | $220 |
| iRGD Peptide ≥95% | 42319 | 25mg | $379 |
| iGRD peptide | SFC27876 | 5mg | $896.5 |
| Density | 1.68±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C, protect from light |
| solubility | DMSO: Soluble: =10 mg/mlPBS (pH 7.2): Soluble: =10 mg/ml |
| form | Solid |
| pka | 2.92±0.70(Predicted) |
| color | White to off-white |
| Water Solubility | Water : ≥ 50 mg/mL (52.74 mM) |
| Sequence | H-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-OH(Disulfide bridge: Cys1-Cys9) |
| FDA UNII | Z8MXU5GH4Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
iRGD price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42319 | iRGD Peptide ≥95% | 1392278-76-0 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 42319 | iRGD Peptide ≥95% | 1392278-76-0 | 5mg | $125 | 2026-04-30 | Buy |
| Cayman Chemical | 42319 | iRGD Peptide ≥95% | 1392278-76-0 | 10mg | $220 | 2026-04-30 | Buy |
| Cayman Chemical | 42319 | iRGD Peptide ≥95% | 1392278-76-0 | 25mg | $379 | 2026-04-30 | Buy |
| Biosynth | SFC27876 | iGRD peptide | 1392278-76-0 | 5mg | $896.5 | 2026-06-05 | Buy |
iRGD Chemical Properties,Uses,Production
Uses
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
in vivo
iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells[2].
References
[1] Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74. DOI:10.1038/gt.2014.52
[2] Zhang L, et al. Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells. Biomed Pharmacother. 2017 Sep;93:1136-1143. DOI:10.1016/j.biopha.2017.06.103
[3] LU LU. Mitochondrial Metabolism Targeted Nanoplatform for Efficient Triple-Negative Breast Cancer Combination Therapy[J]. Advanced Healthcare Materials, 2021, 10 20. DOI: 10.1002/adhm.202100978
[4] YAO Y, SAW P E, NIE Y, et al. Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy†[J]. Journal of Materials Chemistry B, 2018, 4: 576-585. DOI: 10.1039/c8tb02600a
iRGD Preparation Products And Raw materials
Raw materials
Preparation Products
iRGD Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi TNJONE Pharmaceutical Co., Ltd | sarah@tnjone.com | China | 1139 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8898 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd. | +86-13119157289; +86-13119157289 | 13119157289@163.com | China | 999 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16505 | 58 |
| ANHUI BYERSEN BIOTECH CO. LTD | +86-15385096007 +86-17755058861 | amy@byersenchemical.com | China | 9659 | 58 |
| Yiwu Fengjin Commercial Company | +86-19518257926 +86-19164429943 | jaspercc0416@163.com | China | 997 | 58 |
View Lastest Price from iRGD manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | iRGD peptide
1392278-76-0
|
$72.00-513.00 | 98.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-02 | Irgd
1392278-76-0
|
50g | 99% | 100kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2025-04-02 | Opiorphin
1392278-76-0
|
50g | 99% | 100kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |
-
- iRGD peptide
1392278-76-0
- $72.00-513.00
- 98.77%
- TargetMol Chemicals Inc.
-
- Irgd
1392278-76-0
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Opiorphin
1392278-76-0
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
