iRGD
- CAS No.
- 1392278-76-0
- Chemical Name:
- iRGD
- Synonyms
- c(CRGDKGPDC);iRGD;iRGD TFA;iGRD peptide;H-CRGDKGPDC-OH;H-CRGDKGPDC-NH2;iGRD peptide acetate;iRGD peptide TFA salt;inhibit,Inhibitor,iRGD peptide,Integrin;L-Cysteine, L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-, cyclic (1→9)-disulfide
- CBNumber:
- CB33368577
- Molecular Formula:
- C35H57N13O14S2
- Molecular Weight:
- 948.04
- MDL Number:
- MOL File:
- 1392278-76-0.mol
| Product description | Number | Pack Size | Price |
| iRGDpeptide 99.03% | CS-0019023 | 1mg | $90 |
| iRGDpeptide 99.03% | CS-0019023 | 5mg | $360 |
| iRGDpeptide 99.03% | CS-0019023 | 10mg | $620 |
| Density | 1.68±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C, protect from light |
| solubility | DMSO: Soluble: =10 mg/mlPBS (pH 7.2): Soluble: =10 mg/ml |
| form | Solid |
| pka | 2.92±0.70(Predicted) |
| color | White to off-white |
| Water Solubility | Water : ≥ 50 mg/mL (52.74 mM) |
| Sequence | H-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-OH(Disulfide bridge: Cys1-Cys9) |
| FDA UNII | Z8MXU5GH4Q |
iRGD price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0019023 | iRGDpeptide 99.03% | 1392278-76-0 | 1mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0019023 | iRGDpeptide 99.03% | 1392278-76-0 | 5mg | $360 | 2021-12-16 | Buy |
| ChemScene | CS-0019023 | iRGDpeptide 99.03% | 1392278-76-0 | 10mg | $620 | 2021-12-16 | Buy |
iRGD Chemical Properties,Uses,Production
Uses
iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
in vivo
iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells[2].
References
[1] Puig-Saus C, et al. iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy. Gene Ther. 2014 Aug;21(8):767-74. DOI:10.1038/gt.2014.52
[2] Zhang L, et al. Combination of NRP1-mediated iRGD with 5-fluorouracil suppresses proliferation, migration and invasion of gastric cancer cells. Biomed Pharmacother. 2017 Sep;93:1136-1143. DOI:10.1016/j.biopha.2017.06.103
[3] LU LU. Mitochondrial Metabolism Targeted Nanoplatform for Efficient Triple-Negative Breast Cancer Combination Therapy[J]. Advanced Healthcare Materials, 2021, 10 20. DOI: 10.1002/adhm.202100978
[4] YAO Y, SAW P E, NIE Y, et al. Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy†[J]. Journal of Materials Chemistry B, 2018, 4: 576-585. DOI: 10.1039/c8tb02600a
iRGD Preparation Products And Raw materials
Raw materials
Preparation Products
iRGD Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 264 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 | mike@ge-tian.com | China | 269 | 58 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8628 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
View Lastest Price from iRGD manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-19 | iRGD peptide
1392278-76-0
|
US $72.00-513.00 / mg | 98.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-02 | Irgd
1392278-76-0
|
US $0.00 / g | 50g | 99% | 100kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2025-04-02 | Opiorphin
1392278-76-0
|
US $0.00 / g | 50g | 99% | 100kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |
-
- iRGD peptide
1392278-76-0
- US $72.00-513.00 / mg
- 98.77%
- TargetMol Chemicals Inc.
-
- Irgd
1392278-76-0
- US $0.00 / g
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Opiorphin
1392278-76-0
- US $0.00 / g
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
