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Maslinic acid

Maslinic acid Structure
Maslinic acid structure
CAS No.
4373-41-5
Chemical Name:
Maslinic acid
Synonyms
Crataegolic acid;CRATEGOLIC ACID;2α-Hydroxyoleanolic acid;MasL;Crataegic acid;maslinicaci;Masalic acid;Hawthorn acid;Maslinic acid;Maslinic acid-RM
CBNumber:
CB3345863
Molecular Formula:
C30H48O4
Molecular Weight:
472.7
MDL Number:
MFCD00049293
MOL File:
4373-41-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 20:17:46
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Maslinic acid Properties

Melting point 267~269℃
Boiling point 570.0±50.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility acetone: soluble1mg/mL, clear, colorless
pka 4.63±0.70(Predicted)
form powder
color white to off-white
Henry's Law Constant 2.8×105 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Hygroscopic
Major Application food and beverages
Cosmetics Ingredients Functions SKIN CONDITIONING
ANTIOXIDANT
InChIKey MDZKJHQSJHYOHJ-LLICELPBSA-N
SMILES [C@@]12(C)CC[C@@]3([H])C(C)(C)[C@@H](O)[C@H](O)C[C@]3(C)[C@@]1([H])CC=C1[C@]3([H])CC(CC[C@]3(C(=O)O)CC[C@@]21C)(C)C |&1:0,4,9,11,14,16,21,27,33,r|
LogP 7.870 (est)
FDA UNII E233J88OHQ
UNSPSC Code 85151701
NACRES NA.25

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
HS Code  29181990
Storage Class 13 - Non Combustible Solids
Hazardous Substances Data 4373-41-5(Hazardous Substances Data)

Maslinic acid price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M6699 Maslinic acid ≥98% (HPLC) 4373-41-5 5mg $237 2026-04-30 Buy
Sigma-Aldrich 68594 Maslinic acid analytical standard 4373-41-5 5mg $459 2022-05-15 Buy
TCI Chemical M3652 Maslinic Acid 4373-41-5 100MG $241 2026-04-30 Buy
Cayman Chemical 10009645 Maslinic Acid ≥98% 4373-41-5 1mg $35 2026-04-30 Buy
Cayman Chemical 10009645 Maslinic Acid ≥98% 4373-41-5 5mg $116 2026-04-30 Buy
Product number Packaging Price Buy
M6699 5mg $237 Buy
68594 5mg $459 Buy
M3652 100MG $241 Buy
10009645 1mg $35 Buy
10009645 5mg $116 Buy

Maslinic acid Chemical Properties,Uses,Production

Description

Maslinic acid (2-α,3-β-dihydroxyolean-12-en-28-oic acid) is a pentacyclic triterpene abundant in the cuticular lipid layer of olive fruits (Bianchi et al.，1994) .It is a compound of 30 carbon atoms grouped in five cycles that have several substitutes. Maslinic acid presents two hydroxyl groups bound to carbons 2 and 3,one carboxyl group bound to carbon 17, and a double bond between carbons 12 and 13.It is a highly hydrophobic compound of low water solubility. Maslinic acid is synthesized in plants via the cytoplasmic acetate/mevalonate pathway that leads to oxidosqualene (Seo et al., 1988).Oxidosqualene is cycled by various oxidosqualene cyclases, among them β-amyrin synthase, which catalyzes the transformation of oxydosqualene into β-amyrin (olean-12-3n-3β-ol). Afterwards,β-amyrin is converted by successive reactions into erythrodiol, oleanolic acid, and finally maslinic acid (Saimaru et al.,2007; Stiti et al.,2007).

Description

Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 μM), HT-29 human colon cancer cells (EC50 = 74 μM), 1321N1 astrocytoma cells (IC50 = 25 μM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 μM and 9 μM respectively). Maslinic acid''s antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages. Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.

Chemical Properties

Soluble in pyridine, chloroform and methanol mixed solvents, slightly soluble in methanol and ethyl acetate. Derived from red dates, olives, hawthorn, etc.

Uses

Maslinic acid may be used as an analytical reference standard for the quantification of the analyte in the leaves of Ziziphus species and fruits using different chromatography techniques.

Uses

Maslinic Acid is an apoptosis inducer in lung cancer cells, occuring under normoxic and hypoxic conditions.

Definition

Maslinic acid is a pentacyclic triterpenoid that is olean-12-ene substituted by hydroxy groups at positions 2 and 3 and a carboxy group at position 28 (the 2alpha,3beta stereoisomer). It is isolated from Olea europaea and Salvia canariensis and exhibits anti-inflammatory, antioxidant and antineoplastic activity. It has a role as an antioxidant, an antineoplastic agent, an anti-inflammatory agent and a plant metabolite. It is a pentacyclic triterpenoid and a dihydroxy monocarboxylic acid. It derives from a hydride of an oleanane.

General Description

Maslinic acid belongs to the class of triterpenic acids, a group of phytochemicals present in a large variety of plants. It exhibits a broad-spectrum of biological properties such as cardiovascular, antihyperlipidemic, antioxidant effects, hepatoprotective effects, antitumor activity. It is also involved in enhancing the cellular immune system.

Biological Activity

Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 μM), HT-29 human colon cancer cells (EC50 = 74 μM), 1321N1 astrocytoma cells (IC50 = 25 μM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 μM and 9 μM respectively). Maslinic acid's antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages. Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.

Biochem/physiol Actions

Predominant triterpenoid found in olives. Anti-proliferative. Promising chemopreventive agent.

Cytotoxicity

IC50 (μg/mL): 6.48 (518A2), 13.61(HT29),17.58 (MCF-7), 11.06 (A549), 9.22(A2780), 8.04 (8505C) (Siewert et al.2014)
IC50 (μg/mL): 9.97 (NIH-3T3)(Sommerwerk et al. 2016).

References

[1] reyes-zurita f j, rufino-palomares e e, lupiáez j a, et al. maslinic acid, a natural triterpene from olea europaea l., induces apoptosis in ht29 human colon-cancer cells via the mitochondrial apoptotic pathway[j]. cancer letters, 2009, 273(1): 44-54.
[2] garcía, a. compound from olive-pomace oil inhibits hiv spread. 070709111536, 1-1 (2007).
[3] liu j, sun h, duan w, et al. maslinic acid reduces blood glucose in kk-ay mice[j]. biological and pharmaceutical bulletin, 2007, 30(11): 2075-2078.
[4] guan t, qian y, tang x, et al. maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by glt‐1 up‐regulation[j]. journal of neuroscience research, 2011, 89(11): 1829-1839.

Maslinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Maslinic acid Suppliers

Global( 343)Suppliers
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Chengdu Herbpurify Co.Ltd. 2355253622; 18981954830 2355253622@qq.com; China 1089 58
Nanjing Spring & Autumn Biological Engineering Co., Ltd. 17388075642 13815430202 sale02@cqherb.com China 261 59
Shanghai Zhiyun Biotechnology Co., Ltd 13119135307 China 2766 58
Xi'an Ruisi Biotechnology Co., Ltd. 17792397526 164706921@qq.com China 117 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Supplier Advantage
Chembest Research Laboratories Limited 61
Chengdu Herbpurify Co.Ltd. 58
Nanjing Spring & Autumn Biological Engineering Co., Ltd. 59
Shanghai Zhiyun Biotechnology Co., Ltd 58
Xi'an Ruisi Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Adamas Reagent, Ltd. 59
Shanghai Longsheng chemical Co.,Ltd. 59
Sichuan Kulinan Technology Co., Ltd 57
Dalian Meilun Biotech Co., Ltd. 58

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  • Jul 22,2022

View Lastest Price from Maslinic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Maslinic acid pictures 2026-08-25 Maslinic acid
4373-41-5
 1KG 0.99 1000KG Shaanxi Xianhe Biotech Co., Ltd
Maslinic acid pictures 2026-07-27 Maslinic acid
4373-41-5
 $30.00-98.00 99.34% 10g TargetMol Chemicals Inc.
Maslinic acid pictures 2026-05-22 Maslinic acid
4373-41-5
 1kg 98% 1000 kg BINBOBIO CO., LTD.
  • Maslinic acid pictures
  • Maslinic acid
    4373-41-5
  • $30.00-98.00
  • 99.34%
  • TargetMol Chemicals Inc.

Maslinic acid Spectrum

Maslinic acid(4373-41-5)MSMaslinic acid(4373-41-5)1HNMR

4373-41-5(Maslinic acid)Related Search:

4-Hydroxycinnamic acid Stearic acid 1,7-DIOXASPIRO[5.5]UNDECANE Folic acid Ethyl 2-(Chlorosulfonyl)acetate
Oleanolic acid Citric acid Ascoric Acid Methyl maslinate Arjunolic acid
(2α,3β)-2,3-Dihydroxy-olean-12-en-28-oic acid ethyl ester Maslinic acid (2α,3β)-2,3-Dihydroxy-olean-12-en-28-oic acid 2-hydroxyethyl ester, (2α,3β)- 2,3-Bis(acetyloxy)-olean- 12-en-28-oic acid 2,3-BIS(ACETYLOXY)-(2ALPHA,3BETA)-OLEAN-12-EN-28-OIC ACID METHYL ESTER
(2α,3β)-2,3-Dihydroxy-olean-12-en-28-oic acid carboxymethyl ester 2-ACETYLOXY-3-HYDROXY-(2ALPHA,3BETA)-OLEAN-12-EN-28-OIC ACID METHYL ESTER (2α,3β)- 2-(Acetyloxy)-3-hydroxy- olean-12-en-28-oic acid

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MASLINIC ACID, 98% (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid CRATEGOLIC ACID (PLEASE CALL) (2alpha,3beta)-2,3-Dihydroxy-olean-12-en-28-oic acid CRATEGOLIC ACID(MASLINIC ACID)(P) Maslinic Acid(Crategolic Acid) Maslinic acid, Crataegolic acid Crategolic acid, froM Crataegus pinnatifida Olean-12-en-28-oicacid, 2,3-dihydroxy-, (2a,3b)- MASLINIC ACID FROM CRATAEGUS PINNATI Crategolic acid, 98%, from Crataegus pinnatifida Bunge Maslinic acid (2alpha,3beta)-2,3-Dihydroxy-olean-12-en-28-oic acid Keywords Lagerstroemia speciosa extract Keywords loquat leaf extract Maslinic acid 4373-41-5 10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid maslinic acid, HPLC≥98% Maslinic acid 10-98% 2α-Hydroxyoleanoic Acid maslinicaci hot selling maslinic acid Tianfu Chem 4373-41-5 Maslinic acid Maslinic acid (6CI) inhibit,Nuclear factor-κB,Human immunodeficiency virus,HIV,Maslinic acid,Nuclear factor-kappaB,NF-κB,Inhibitor,Bacterial (4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-Dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Olean-12-en-28-oic acid, 2,3-dihydroxy-, (2α,3β)- Hawthorn acid Masalic acid Maslinic acid-RM Masalic Acid Powder Maslinic acid, 10 mM in DMSO Maslinic acid Olive Extract Maslinic Acid Maslinic acid (Standard) 2α-Hydroxyoleanolic acid Crataegic acid CRATEGOLIC ACID Crataegolic acid MasL 4373-41-5 Miscellaneous Pentacyclic Triterpenes Natural Products